Search Results - "Moraes, Natalia Valadares"

Effect of Roux‐En‐Y Gastric Bypass in the Pharmacokinetics of (R)‐Carvedilol and (S)‐Carvedilol by Yamamoto, Priscila Akemi, Cristofoletti, Rodrigo, Vozmediano, Valvanera, Gaitani, Cristiane Masetto, da Silva, Rodrigo Moreira, Kemp, Rafael, Sankarankutty, Ajith Kumar, Salgado Junior, Wilson, Santos, Jose Sebastião dos, Moraes, Natalia Valadares

“…Roux‐en‐Y gastric bypass is one of the most common surgical treatments for obesity due to the effective long‐term weight loss and remission of associated…”
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Impact of obesity and roux‐en‐Y gastric bypass on the pharmacokinetics of (R)‐ and (S)‐omeprazole and intragastric pH by Pippa, Leandro F., Vozmediano, Valvanera, Mitrov‐Winkelmolen, Lieke, Touw, Daan, Soliman, Amira, Cristofoletti, Rodrigo, Salgado Junior, Wilson, de Moraes, Natalia Valadares

“…This study employed physiologically‐based pharmacokinetic–pharmacodynamics (PBPK/PD) modeling to predict the effect of obesity and gastric bypass surgery on…”
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IN VITRO METABOLISM OF COPALIC AND KAURENOIC ACIDS IN RAT AND HUMAN LIVER MICROSOMES by Mauro, Mariana, Silva, Rodrigo, Campos, Michel, Bauermeister, Anelize, Lopes, Norberto, Moraes, Natalia

“…Copalic (CA) and kaurenoic (KA) acids are the main diterpenes found in the oleoresin extracted from the copaiba tree (Copaifera sp). This study aimed to…”
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Rerouting cardiovascular management following gastric bypass surgery: Dose optimization of carvedilol using population‐based analysis by Yamamoto, Priscila Akemi, Vozmediano, Valvanera, Cristofoletti, Rodrigo, Jiang, Jinmai, Schmittgen, Thomas D., Gaitani, Cristiane Masetto, Kemp, Rafael, Sankarankutty, Ajith Kumar, Santos, Jose Sebastião, Salgado Junior, Wilson, Moraes, Natalia Valadares

“…Aims A population‐based pharmacokinetic (PK) modeling approach (PopPK) was used to investigate the impact of Roux‐en‐Y gastric bypass (RYGB) on the PK of (R)‐…”
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Mechanistic Framework to Predict Maternal‐Placental‐Fetal Pharmacokinetics of Nifedipine Employing Physiologically Based Pharmacokinetic Modeling Approach by Werdan Romão, Marya Antônya, Pinto, Leonardo, Cavalli, Ricardo Carvalho, Duarte, Geraldo, Moraes, Natália Valadares, Abduljalil, Khaled, Moreira, Fernanda de Lima

“…Nifedipine is used for treating mild to severe hypertension and preventing preterm labor in pregnant women. Nevertheless, concerns about nifedipine fetal…”
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Assessing the contribution of UGT isoforms on raltegravir drug disposition through PBPK modeling by Moreira, Fernanda-de-Lima, Tarozzo, Maria-Martha-de-Barros, Nardotto, Glauco-Henrique-Balthazar, Gonçalves, José-Carlos-Saraiva, Schmidt, Stephan, de-Moraes, Natália-Valadares

“…This work aimed to develop a physiologically based pharmacokinetic (PBPK) model for raltegravir accounting for UDP-glucuronosyltransferase (UGT) metabolism to…”
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Casearia essential oil: an updated review on the chemistry and pharmacological activities by Carvalho, Flávio Alexandre, Moraes, Natália Valadares de, Crotti, Antônio Eduardo Miller, Crevelin, Eduardo José, Gonzaga Dos Santos, André

“…Casearia species are found in the America, Africa, Asia, and Australia and present pharmacological activities, besides their traditional uses. Here, we…”
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Population pharmacokinetics of gabapentin in patients with neuropathic pain: Lack of effect of diabetes or glycaemic control by Costa, Ana Carolina Conchon, Lima Benzi, Jhohann Richard, Yamamoto, Priscila Akemi, Freitas, Maria Cristina Foss, Paula, Francisco José Albuquerque, Zanelli, Cleslei Fernando, Lauretti, Gabriela Rocha, Moraes, Natália Valadares

“…Aims Gabapentin (GBP) is widely used to treat neuropathic pain, including diabetic neuropathic pain. Our objective was to evaluate the role of diabetes and…”
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Therapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic pain by Yamamoto, Priscila Akemi, Benzi, Jhohann Richard de Lima, Dach, Fabíola, Moraes, Natália Valadares de

“…Abstract Gabapentin is an antiepileptic drug prescribed for several neuropathic pain conditions. This study aimed to evaluate gabapentin (GAB) trough plasma…”
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Pharmacogenomics in chronic pain therapy: from disease to treatment and challenges for clinical practice by Yamamoto, Priscila Akemi, Conchon Costa, Ana Carolina, Lauretti, Gabriela Rocha, de Moraes, Natália Valadares

“…Pharmacogenomics (PGx) has emerged as an encouraging tool in chronic pain therapy. Genetic variations associated with drug effectiveness or adverse reactions…”
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Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations by Costa, Ana Carolina Conchon, Yamamoto, Priscila Akemi, Lauretti, Gabriela Rocha, Benzi, Jhohann Richard, Zanelli, Cleslei Fernando, Barz, Vivien, Ciarimboli, Giuliano, Moraes, Natália Valadares

“…Gabapentin (GBP) is an organic cation mainly eliminated unchanged in urine, and active drug secretion has been suggested to contribute to its renal excretion…”
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ABCG2 c.421C>A polymorphism alters nifedipine transport to breast milk in hypertensive breastfeeding women by Malfará, Bianca Nayra, Benzi, Jhohann Richard de Lima, de Oliveira Filgueira, Gabriela Campos, Zanelli, Cleslei Fernando, Duarte, Geraldo, de Carvalho Cavalli, Ricardo, de Moraes, Natália Valadares

“…•Nifedipine is prescribed to treat chronic hypertension during breastfeeding.•Nifedipine is substrate of ABCG2, a drug transporter found in mammary…”
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Determination of mitragynine in rat plasma by LC–MS/MS: Application to pharmacokinetics by de Moraes, Natália Valadares, Moretti, Raquel Alves Corrêa, Furr, Edward B., McCurdy, Christopher R., Lanchote, Vera Lucia

“…This study used for the first time LC–MS/MS for the analysis of mitragynine (MIT), a μ-opioid agonist with antinociceptive and antitussive properties, in rat…”
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Effects of type 1 and type 2 diabetes on the pharmacokinetics of tramadol enantiomers in patients with neuropathic pain phenotyped as cytochrome P450 2D6 extensive metabolizers by de Moraes, Natália Valadares, Lauretti, Gabriela Rocha, Lanchote, Vera Lucia

“…Objectives The aim of this study was to evaluate the influence of poorly controlled type 1 (T1DM) and type 2 diabetes mellitus (T2DM) on the pharmacokinetics…”
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Pharmacokinetics of Carboplatin in Combination with Low-Dose Cyclophosphamide in Female Dogs with Mammary Carcinoma by Machado, Marília Carneiro, Yamamoto, Priscila Akemi, Pippa, Leandro Francisco, de Moraes, Natália Valadares, Neves, Fabiane Maria Fernandes, Portela, Ricardo Dias, Barrouin-Melo, Stella Maria, Hielm-Björkman, Anna, Godoy, Ana Leonor Pardo Campos, Estrela-Lima, Alessandra

“…This prospective study aimed to evaluate the effect of metronomic cyclophosphamide on carboplatin’s tolerability, efficacy, and pharmacokinetics in dogs with…”
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Enantioselective analysis of unbound tramadol, O-desmethyltramadol and N-desmethyltramadol in plasma by ultrafiltration and LC–MS/MS: Application to clinical pharmacokinetics by de Moraes, Natália Valadares, Lauretti, Gabriela Rocha, Napolitano, Marcio Nogueira, Santos, Naiane Ribeiro, Godoy, Ana Leonor Pardo Campos, Lanchote, Vera Lucia

“…► Binding of drugs to plasma proteins can be stereoselective. ► Unbound concentrations of tramadol, M1 and M2 enantiomers were analyzed by MS/MS. ► Kinetics of…”
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L-arginine, a nitric oxide precursor, reduces dapsone-induced methemoglobinemia in rats by Moraes, Natália Valadares de, Bergamaschi, Mateus Machado, Bianchi, Maria de Lourdes Pires, Bragheto, Juliana Bordinassi, Malfará, Wilson Roberto, Queiroz, Regina Helena Costa

“…Dapsone use is frequently associated to hematological side effects such as methemoglobinemia and hemolytic anemia, which are related to N-hydroxylation…”
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The role of organic cation transporter 2 inhibitor cimetidine, experimental diabetes mellitus and metformin on gabapentin pharmacokinetics in rats by Benzi, Jhohann Richard de Lima, Yamamoto, Priscila Akemi, Stevens, Jessica Hanna, Baviera, Amanda Martins, de Moraes, Natália Valadares

“…We investigated the influence of diabetes mellitus (DM), glycemic control with insulin, cimetidine (Oct2 inhibitor) and metformin (Oct2 substrate) on the…”
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Simple and rapid HPLC-UV methods for gabapentin quantification in human plasma and urine: applicability in pharmacokinetics and drug monitoring by Yamamoto, Priscila Akemi, Benzi, Jhohann Richard de Lima, Moraes, Natália Valadares de

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Simultaneous analysis of tramadol, O-desmethyltramadol, and N-desmethyltramadol enantiomers in rat plasma by high-performance liquid chromatography-tandem mass spectrometry: Application to pharmacokinetics by Godoy, Ana Leonor Pardo Campos, De Moraes, Natália Valadares, Martinez, Edson Zangiacomi, Carvalho, Teresa Maria De Jesus Ponte, Marques, Maria Paula, Lanchote, Vera Lucia

“…Tramadol (T) is available as a racemic mixture of (+)‐trans‐T and (−)‐trans‐T. The main metabolic pathways are O‐demethylation and N‐demethylation, producing…”
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