Search Results - "Moraes, Karen C.M."

CUG-BP binds to RNA substrates and recruits PARN deadenylase by Moraes, Karen C M, Wilusz, Carol J, Wilusz, Jeffrey

“…CUG-BP is the human homolog of the Xenopus EDEN-BP, which was shown previously to bind to mRNAs, such as c-mos, that exhibit rapid deadenylation following…”
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Role of cyclooxygenase-2 in Trypanosoma cruzi survival in the early stages of parasite host-cell interaction by Moraes, Karen C.M, Diniz, Lívia F, Bahia, Maria Terezinha

“…Chagas disease, caused by the intracellular protozoan Trypanosoma cruzi, is a serious health problem in Latin America. During this parasitic infection, the…”
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Lsm proteins bind and stabilize RNAs containing 5′ poly(A) tracts by Bergman, Naomi, Anderson, John R, Schneider, Robert J, Kambach, Christian, Moraes, Karen C M, Wilusz, Carol J, Wilusz, Jeffrey, Zaric, Bozidarka

“…Many orthopoxvirus messenger RNAs have an unusual nontemplated poly(A) tract of 5 to 40 residues at the 5' end. The precise function of this feature is…”
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Evaluation of photodynamic therapy in adhesion protein expression by PACHECO-SOARES, CRISTINA, MAFTOU-COSTA, MAIRA, DA CUNHA MENEZES COSTA, CAROLINA GENÚNCIO, DE SIQUEIRA SILVA, ANDREZA CRISTINA, MORAES, KAREN C.M

“…Photodynamic therapy (PDT) is a treatment modality that has clinical applications in both non-neoplastic and neoplastic diseases. PDT involves a…”
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Candida albicans: genotyping methods and clade related phenotypic characteristics by Lyon, Juliana P, Moraes, Karen C M, Moreira, Leonardo M, Aimbire, Flávio, de Resende, Maria Aparecida

“…Several molecular methods, such as Southern blotting hybridization, Multilocus Sequence Typing, and DNA microsatellite analysis, have been employed to genotype…”
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CUG-BP and 3'UTR sequences influence PARN-mediated deadenylation in mammalian cell extracts by Moraes, Karen C.M., Wilusz, Carol J., Wilusz, Jeffrey

“…Several mRNAs have been shown to exhibit distinct patterns of poly(A) shortening prior to their decay in vivo. In this study, we show that individual…”
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Non-alcoholic fatty liver disease establishment and progression: genetics and epigenetics as relevant modulators of the pathology by Pansa, Camila Cristiane, Molica, Letícia Ramos, Moraes, Karen C. M.

“…Non-alcoholic fatty liver disease (NAFLD) results from metabolic dysfunctions that affect more than one-third of the world population. Over the last decades,…”
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Molecular interplays in hepatic stellate cells: apoptosis, senescence, and phenotype reversion as cellular connections that modulate liver fibrosis by de Oliveira da Silva, Brenda, Ramos, Letícia Ferrreira, Moraes, Karen C. M.

“…Liver fibrosis is a pathophysiological process correlated with intense repair and cicatrization mechanisms in injured liver, and over the past few years, the…”
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Drosophila melanogaster: A Powerful Tiny Animal Model for the Study of Metabolic Hepatic Diseases by Moraes, Karen C. M., Montagne, Jacques

“…Animal experimentation is limited by unethical procedures, time-consuming protocols, and high cost. Thus, the development of innovative approaches for disease…”
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Cellular and molecular effects of silymarin on the transdifferentiation processes of LX-2 cells and its connection with lipid metabolism by Silva, Caio Mateus, Ferrari, Gustavo Duarte, Alberici, Luciane Carla, Malaspina, Osmar, Moraes, Karen C. M.

“…Fibrosis process in the liver is a clinical condition established in response to chronic lesions and may be reversible in many situations. In this process,…”
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Cellular and molecular effects of fipronil in lipid metabolism of HepG2 and its possible connection to non‐alcoholic fatty liver disease by Pansa, Camila C., Molica, Letícia R., Oliveira Júnior, Fabiano C., Santello, Lara C., Moraes, Karen C. M.

“…Nonalcoholic fatty liver disease (NAFLD) is a global public health problem that affects more than a quarter of the population. The development of this disease…”
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Altered global microRNA expression in hepatic stellate cells LX-2 by angiotensin-(1–7) and miRNA-1914-5p identification as regulator of pro-fibrogenic elements and lipid metabolism by de Oliveira da Silva, Brenda, Alberici, Luciane Carla, Ramos, Letícia Ferreira, Silva, Caio Mateus, da Silveira, Marina Bonfogo, Dechant, Carlos R.P., Friedman, Scott L., Sakane, Kumiko Koibuchi, Gonçalves, Letícia Rocha, Moraes, Karen C.M.

“…•Therapeutics to control or reverse hepatic fibrosis requires molecular investigation.•In the liver, hepatic stellate cells play a major role in promoting…”
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Non-alcoholic fatty liver disease: molecular and cellular interplays of the lipid metabolism in a steatotic liver by Ramos, Letícia F, Silva, Caio M, Pansa, Camila C, Moraes, Karen C M

“…Non-alcoholic fatty liver disease (NAFLD) affects ~25% of world population and cases have increased in recent decades. These anomalies have several etiologies;…”
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Mir-513a-3p contributes to the controlling of cellular migration processes in the A549 lung tumor cells by modulating integrin β-8 expression by da Silveira, Marina Bonfogo, Lima, Kelvin Furtado, da Silva, Andrea Renata, dos Santos, Robson Augusto Souza, Moraes, Karen C. M.

“…Lung tumors are a frequent type of cancer in humans and a leading cause of death, and the late diagnostic contributes to high mortality rates. New therapeutic…”
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Drosophila melanogaster as a Biotechnological Tool to Investigate the Close Connection Between Fatty Diseases and Pesticides by de Oliveira-Júnior, Fabiano Cláudio, Oliveira, Ana Caroline Pimentel de, Pansa, Camila Cristiane, Molica, Letícia Ramos, Moraes, Karen C. M.

“…Abstract Nonalcoholic fatty liver disease (NAFLD) is a public health problem developed by different etiologies, which induces metabolic dysfunctions and…”
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The functional activity of the miR-1914-5p in lipid metabolism of the hepatocarcinoma cell line HepG2: a potential molecular tool for controlling hepatic cellular migration by da Silveira, Marina Bonfogo, Pansa, Camila Cristiane, Malaspina, Osmar, Moraes, Karen C. M.

“…Hepatocellular carcinoma is one of the most common types of cancer in the world with high mortality rate and new therapies that control of fatty acid…”
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Altered global microRNA expression in hepatic stellate cells LX-2 by angiotensin-(1–7) and miRNA-1914-5p identification as regulator of profibrogenic elements and lipid metabolism by de Oliveira da Silva, Brenda, Alberici, Luciane Carla, Ramos, Letícia Ferreira, Silva, Caio Mateus, da Silveira, Marina Bonfogo, Dechant, Carlos R.P., Friedman, Scott L., Sakane, Kumiko Koibuchi, Gonçalves, Letícia Rocha, Moraes, Karen C.M.

“…The development of new therapeutic strategies to control or reverse hepatic fibrosis requires thorough knowledge about its molecular and cellular basis. It is…”
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Mir-351-5p contributes to the establishment of a pro-inflammatory environment in the H9c2 cell line by repressing PTEN expression by da Silva, Walmir, dos Santos, Robson Augusto Souza, Moraes, Karen C. M.

“…The activated renin–angiotensin–aldosterone system modulates several metabolic pathways that contribute to left ventricular hypertrophy and heart failure. In…”
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MicroRNA Profiling of the Effect of the Heptapeptide Angiotensin-(1-7) in A549 Lung Tumor Cells Reveals a Role for miRNA149-3p in Cellular Migration Processes by Silva, Brenda de Oliveira da, Lima, Kelvin Furtado, Gonçalves, Letícia Rocha, Silveira, Marina Bonfogo da, Moraes, Karen C M

“…Lung cancer is one of the most frequent types of cancer in humans and a leading cause of death worldwide. The high mortality rates are correlated with late…”
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Mir-190b negatively contributes to the Trypanosoma cruzi -infected cell survival by repressing PTEN protein expression by Monteiro, Cíntia Júnia, Mota, Suianne Letícia Antunes, Diniz, Lívia de Figueiredo, Bahia, Maria Terezinha, Moraes, Karen C.M

“…Chagas disease, which is caused by the intracellular protozoan Trypanosoma cruzi , is a serious health problem in Latin America. The heart is one of the major…”
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