Search Results - "Moraes, Karen C. M"

Cellular and molecular effects of silymarin on the transdifferentiation processes of LX-2 cells and its connection with lipid metabolism by Silva, Caio Mateus, Ferrari, Gustavo Duarte, Alberici, Luciane Carla, Malaspina, Osmar, Moraes, Karen C. M.

“…Fibrosis process in the liver is a clinical condition established in response to chronic lesions and may be reversible in many situations. In this process,…”
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MicroRNA Profiling of the Effect of the Heptapeptide Angiotensin-(1-7) in A549 Lung Tumor Cells Reveals a Role for miRNA149-3p in Cellular Migration Processes by Silva, Brenda de Oliveira da, Lima, Kelvin Furtado, Gonçalves, Letícia Rocha, Silveira, Marina Bonfogo da, Moraes, Karen C M

“…Lung cancer is one of the most frequent types of cancer in humans and a leading cause of death worldwide. The high mortality rates are correlated with late…”
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Correction: MicroRNA Profiling of the Effect of the Heptapeptide Angiotensin-(1-7) in A549 Lung Tumor Cells Reveals a Role for miRNA149-3p in Cellular Migration Processes by Silva, Brenda de Oliveira da, Lima, Kelvin Furtado, Gonçalves, Letícia Rocha, Silveira, Marina Bonfogo da, Moraes, Karen C M

“…[This corrects the article DOI: 10.1371/journal.pone.0162094.]…”
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Inhibition of the miR-1914-5p increases the oxidative metabolism in cellular model of steatosis by modulating the Sirt1-PGC-1α pathway and systemic cellular activity by Porto-Barbosa, Thais, Ramos, Letícia Ferreira, Pansa, Camila Cristiane, Molica, Letícia Ramos, Malaspina, Osmar, Moraes, Karen C. M.

“…Metabolic associated fatty liver disease (MAFLD) is considered an indicator of metabolic syndrome, which affects millions of people around the world and no…”
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Drosophila melanogaster: A Powerful Tiny Animal Model for the Study of Metabolic Hepatic Diseases by Moraes, Karen C. M., Montagne, Jacques

“…Animal experimentation is limited by unethical procedures, time-consuming protocols, and high cost. Thus, the development of innovative approaches for disease…”
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Mir-190b negatively contributes to the Trypanosoma cruzi-infected cell survival by repressing PTEN protein expression by Monteiro, Cíntia Júnia, Mota, Suianne Letícia Antunes, Diniz, Lívia de Figueiredo, Bahia, Maria Terezinha, Moraes, Karen C M

“…Chagas disease, which is caused by the intracellular protozoan Trypanosoma cruzi, is a serious health problem in Latin America. The heart is one of the major…”
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The functional activity of the miR-1914-5p in lipid metabolism of the hepatocarcinoma cell line HepG2: a potential molecular tool for controlling hepatic cellular migration by da Silveira, Marina Bonfogo, Pansa, Camila Cristiane, Malaspina, Osmar, Moraes, Karen C. M.

“…Hepatocellular carcinoma is one of the most common types of cancer in the world with high mortality rate and new therapies that control of fatty acid…”
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Mir-351-5p contributes to the establishment of a pro-inflammatory environment in the H9c2 cell line by repressing PTEN expression by da Silva, Walmir, dos Santos, Robson Augusto Souza, Moraes, Karen C. M.

“…The activated renin–angiotensin–aldosterone system modulates several metabolic pathways that contribute to left ventricular hypertrophy and heart failure. In…”
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CUG-BP binds to RNA substrates and recruits PARN deadenylase by Moraes, Karen C M, Wilusz, Carol J, Wilusz, Jeffrey

“…CUG-BP is the human homolog of the Xenopus EDEN-BP, which was shown previously to bind to mRNAs, such as c-mos, that exhibit rapid deadenylation following…”
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Role of cyclooxygenase-2 in Trypanosoma cruzi survival in the early stages of parasite host-cell interaction by Moraes, Karen C.M, Diniz, Lívia F, Bahia, Maria Terezinha

“…Chagas disease, caused by the intracellular protozoan Trypanosoma cruzi, is a serious health problem in Latin America. During this parasitic infection, the…”
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MicroRNA‐1254 contributes to the controlling of pro‐fibrogenic environment in LX‐2 cells by modulating SMAD3 and wound repair: new insights in hepatic fibrosis by Gonçalves, Letícia Rocha, de Oliveira da Silva, Brenda, Scarinci, Letícia Destefani, Ramos, Letícia Ferreira, Moraes, Karen C.M.

“…Hepatic fibrosis and its end‐stage cirrhosis have increased worldwide, and, despite all the efforts, no successful therapy is available. More recently, the…”
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Cellular and molecular effects of Baccharis dracunculifolia D.C. and Plectranthus barbatus Andrews medicinal plant extracts on retinoid metabolism in the human hepatic stellate cell LX-2 by da Silva, Caio Mateus, Caetano, Flávio Henrique, Pereira, Franco Dani Campos, Morales, Maria Aparecida Marin, Sakane, Kumiko Koibuchi, Moraes, Karen C M

“…Chronic hepatic diseases are serious problems worldwide, which may lead to the development of fibrosis and eventually cirrhosis. Despite the significant number…”
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Riboswitch theo/ metE as a Transcription Regulation Tool for Xanthomonas citri subsp. citri by Bueno, Danilo, Pedrolli, Danielle B, Martins, Paula M M, Bocchini, Daniela A, Moraes, Karen C M, Facincani, Agda P, Ferro, Jesus A, Varani, Alessandro M, Pena, Michelle M, Ferreira, Henrique

“…subsp. ( ) is the causal agent of Asiatic Citrus Canker (ACC), a disease that affects citrus. ACC has no cure, and growers must rely on special agricultural…”
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RNA surveillance: molecular approaches in transcript quality control and their implications in clinical diseases by Moraes, Karen C M

“…Production of mature mRNAs that encode functional proteins involves highly complex pathways of synthesis, processing and surveillance. At numerous steps during…”
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Non-alcoholic fatty liver disease establishment and progression: genetics and epigenetics as relevant modulators of the pathology by Pansa, Camila Cristiane, Molica, Letícia Ramos, Moraes, Karen C. M.

“…Non-alcoholic fatty liver disease (NAFLD) results from metabolic dysfunctions that affect more than one-third of the world population. Over the last decades,…”
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Molecular interplays in hepatic stellate cells: apoptosis, senescence, and phenotype reversion as cellular connections that modulate liver fibrosis by de Oliveira da Silva, Brenda, Ramos, Letícia Ferrreira, Moraes, Karen C. M.

“…Liver fibrosis is a pathophysiological process correlated with intense repair and cicatrization mechanisms in injured liver, and over the past few years, the…”
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Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome by Anderson, John R, Mukherjee, Devi, Muthukumaraswamy, Karthika, Moraes, Karen C M, Wilusz, Carol J, Wilusz, Jeffrey

“…We have previously demonstrated that PM-Scl-75, a component of the human exosome complex involved in RNA maturation and mRNA decay, can specifically interact…”
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Cellular and molecular effects of fipronil in lipid metabolism of HepG2 and its possible connection to non‐alcoholic fatty liver disease by Pansa, Camila C., Molica, Letícia R., Oliveira Júnior, Fabiano C., Santello, Lara C., Moraes, Karen C. M.

“…Nonalcoholic fatty liver disease (NAFLD) is a global public health problem that affects more than a quarter of the population. The development of this disease…”
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Altered global microRNA expression in hepatic stellate cells LX-2 by angiotensin-(1–7) and miRNA-1914-5p identification as regulator of pro-fibrogenic elements and lipid metabolism by de Oliveira da Silva, Brenda, Alberici, Luciane Carla, Ramos, Letícia Ferreira, Silva, Caio Mateus, da Silveira, Marina Bonfogo, Dechant, Carlos R.P., Friedman, Scott L., Sakane, Kumiko Koibuchi, Gonçalves, Letícia Rocha, Moraes, Karen C.M.

“…•Therapeutics to control or reverse hepatic fibrosis requires molecular investigation.•In the liver, hepatic stellate cells play a major role in promoting…”
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Non-alcoholic fatty liver disease: molecular and cellular interplays of the lipid metabolism in a steatotic liver by Ramos, Letícia F, Silva, Caio M, Pansa, Camila C, Moraes, Karen C M

“…Non-alcoholic fatty liver disease (NAFLD) affects ~25% of world population and cases have increased in recent decades. These anomalies have several etiologies;…”
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