Search Results - "Moradi Chameh, Homeira"
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Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences
Published in Nature communications (03-05-2021)“…In the human neocortex coherent interlaminar theta oscillations are driven by deep cortical layers, suggesting neurons in these layers exhibit distinct…”
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Brief activation of GABAergic interneurons initiates the transition to ictal events through post-inhibitory rebound excitation
Published in Neurobiology of disease (01-01-2018)“…Activation of γ-aminobutyric acid (GABAA) receptors have been associated with the onset of epileptiform events. To investigate if a causal relationship exists…”
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Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits
Published in Cell reports (Cambridge) (11-01-2022)“…Cortical processing depends on finely tuned excitatory and inhibitory connections in neuronal microcircuits. Reduced inhibition by somatostatin-expressing…”
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Author Correction: Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences
Published in Nature communications (24-03-2022)Get full text
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Effect of low frequency repetitive transcranial magnetic stimulation on kindling-induced changes in electrophysiological properties of rat CA1 pyramidal neurons
Published in Brain research (05-05-2015)“…Abstract In this study, the effect of repetitive transcranial magnetic stimulation (rTMS) on the kindling induced changes in electrophysiological firing…”
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Loss of neuronal heterogeneity in epileptogenic human tissue impairs network resilience to sudden changes in synchrony
Published in Cell reports (Cambridge) (24-05-2022)“…A myriad of pathological changes associated with epilepsy can be recast as decreases in cell and circuit heterogeneity. We thus propose recontextualizing…”
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Regulating hippocampal hyperexcitability through GABAB Receptors
Published in Physiological reports (01-04-2014)“…Disturbances of GABAergic inhibition are a major cause of epileptic seizures. GABA exerts its actions via ionotropic GABAA receptors and metabotropic G…”
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Loss of neuronal heterogeneity in epileptogenic human tissue impairs network resilience to sudden changes in synchrony
Published in Cell reports (Cambridge) (18-10-2022)Get full text
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Modeling Reveals Human–Rodent Differences in H-Current Kinetics Influencing Resonance in Cortical Layer 5 Neurons
Published in Cerebral cortex (New York, N.Y. 1991) (05-01-2021)“…Abstract While our understanding of human neurons is often inferred from rodent data, inter-species differences between neurons can be captured by building…”
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Fingolimod Administration Following Hypoxia Induced Neonatal Seizure Can Restore Impaired Long-term Potentiation and Memory Performance in Adult Rats
Published in Neuroscience (21-05-2023)“…•FTY720 administration following HINS could restore the dysregulated gene expression of excitatory and inhibitory receptors.•FTY720 administration following…”
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Inhibitory Network Bistability Explains Increased Interneuronal Activity Prior to Seizure Onset
Published in Frontiers in neural circuits (14-01-2020)“…Recent experimental literature has revealed that GABAergic interneurons exhibit increased activity prior to seizure onset, alongside additional evidence that…”
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Hyperpolarization-activated cation channels shape the spiking frequency preference of human cortical layer 5 pyramidal neurons
Published in eNeuro (01-08-2023)“…Discerning the contribution of specific ionic currents to complex neuronal dynamics is a difficult, but important, task. This challenge is exacerbated in the…”
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Distinctive biophysical features of human cell-types: insights from studies of neurosurgically resected brain tissue
Published in Frontiers in synaptic neuroscience (04-10-2023)“…Electrophysiological characterization of live human tissue from epilepsy patients has been performed for many decades. Although initially these studies sought…”
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Corrigendum: Inhibitory Network Bistability Explains Increased Interneuronal Activity Prior to Seizure Onset
Published in Frontiers in neural circuits (06-09-2021)Get full text
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An in vitro whole-cell electrophysiology dataset of human cortical neurons
Published in Gigascience (15-11-2022)“…Abstract Background Whole-cell patch-clamp electrophysiology is an essential technique for understanding how single neurons translate their diverse inputs into…”
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In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression
Published in Communications biology (23-02-2024)“…Reduced inhibition by somatostatin-expressing interneurons is associated with depression. Administration of positive allosteric modulators of α5…”
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Author Correction: A community-based transcriptomics classification and nomenclature of neocortical cell types
Published in Nature neuroscience (01-04-2021)“…A Correction to this paper has been published: https://doi.org/10.1038/s41593-020-00779-0…”
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Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity
Published in Cerebral cortex (New York, N.Y. 1991) (04-04-2023)“…Abstract Aging involves various neurobiological changes, although their effect on brain function in humans remains poorly understood. The growing availability…”
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A community-based transcriptomics classification and nomenclature of neocortical cell types
Published in Nature neuroscience (01-12-2020)“…To understand the function of cortical circuits, it is necessary to catalog their cellular diversity. Past attempts to do so using anatomical, physiological or…”
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Anticonvulsive effects of endocannabinoids; an investigation to determine the role of regulatory components of endocannabinoid metabolism in the Pentylenetetrazol induced tonic- clonic seizures
Published in Metabolic brain disease (01-06-2018)“…2-Arachidonoylglycerol (2-AG) and anandamide are two major endocannabinoids produced, released and eliminated by metabolic pathways. Anticonvulsive effect of…”
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