Search Results - "Morad, Martin"

Calcium Signaling Consequences of RyR2-S4938F Mutation Expressed in Human iPSC-Derived Cardiomyocytes by Toth, Noemi, Zhang, Xiao-Hua, Zamaro, Alexandra, Morad, Martin

“…Type-2 ryanodine receptor (RyR2) is the major Ca release channel of the cardiac sarcoplasmic reticulum (SR) that controls the rhythm and strength of the…”
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Regulation of Ca2+ signaling by acute hypoxia and acidosis in cardiomyocytes derived from human induced pluripotent stem cells by Fernández-Morales, José-Carlos, Hua, Wei, Yao, Yuyu, Morad, Martin

“…•Human Induced Pluripotent Stem Cell–derived CMs express two cell populations based on inactivation kinetics of L-type ICa (τi 20ms & 50ms).•The diverse…”
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Pressure–flow‘‐triggered intracellular Ca2+ transients in rat cardiac myocytes: possible mechanisms and role of mitochondria by Belmonte, Stephen, Morad, Martin

“…Cardiac myocytes, in the intact heart, are exposed to shear/fluid forces during each cardiac cycle. Here we describe a novel Ca2+ signalling pathway, generated…”
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Regulation of Ca2+ signaling by acute hypoxia and acidosis in rat neonatal cardiomyocytes by Fernández-Morales, José-Carlos, Morad, Martin

“…Ischemic heart disease is an arrhythmogenic condition, accompanied by hypoxia, acidosis, and impaired Ca2+ signaling. Here we report on effects of acute…”
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Fast-Response Calmodulin-Based Fluorescent Indicators Reveal Rapid Intracellular Calcium Dynamics by Helassa, Nordine, Zhang, Xiao-hua, Conte, Ianina, Scaringi, John, Esposito, Elric, Bradley, Jonathan, Carter, Thomas, Ogden, David, Morad, Martin, Török, Katalin

“…Faithful reporting of temporal patterns of intracellular Ca 2+ dynamics requires the working range of indicators to match the signals. Current genetically…”
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In vitro Modeling of Ryanodine Receptor 2 Dysfunction Using Human Induced Pluripotent Stem Cells by Fatima, Azra, Xu, Guoxing, Shao, Kaifeng, Papadopoulos, Symeon, Lehmann, Martin, Arnáiz-Cot, Juan J., Rosa, Angelo O., Nguemo, Filomain, Matzkies, Matthias, Dittmann, Sven, Stone, Susannah L., Linke, Matthias, Zechner, Ulrich, Beyer, Vera, Hennies, Hans Christian, Rosenkranz, Stephan, Klauke, Baerbel, Parwani, Abdul S., Haverkamp, Wilhelm, Pfitzer, Gabriele, Farr, Martin, Cleemann, Lars, Morad, Martin, Milting, Hendrik, Hescheler, Juergen, Šaric, Tomo

“…Background/Aims: Induced pluripotent stem (iPS) cells generated from accessible adult cells of patients with genetic diseases open unprecedented opportunities…”
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Shear Fluid-induced Ca2+ Release and the Role of Mitochondria in Rat Cardiac Myocytes by Belmonte, Steve, Morad, Martin

“…Cardiac myocyte contraction occurs when Ca2+ influx through voltage‐gated L‐type Ca2+ channels causes Ca2+ release from ryanodine receptors of the sarcoplasmic…”
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Diversity of mitochondrial Ca2+ signaling in rat neonatal cardiomyocytes: Evidence from a genetically directed Ca2+ probe, mitycam-E31Q by Haviland, Sarah, Cleemann, Lars, Kettlewell, Sarah, Smith, Godfrey L, Morad, Martin

“…Graphical abstract…”
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Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells by Sasse, Philipp, Zhang, Jianbao, Cleemann, Lars, Morad, Martin, Hescheler, Juergen, Fleischmann, Bernd K

“…Early (E9.5-E11.5) embryonic heart cells beat spontaneously, even though the adult pacemaking mechanisms are not yet fully established. Here we show that in…”
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Diversity of Ca2+ Signaling in Developing Cardiac Cells by JANOWSKI, EINSLEY, CLEEMANN, LARS, SASSE, PHILIPP, MORAD, MARTIN

“…:  During embryonic and postnatal development, the mammalian heart undergoes rapid morphological changes with cellular differentiation that at the…”
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Diversity of atrial local Ca2+ signalling: evidence from 2-D confocal imaging in Ca2+-buffered rat atrial myocytes by Woo, Sun‐Hee, Cleemann, Lars, Morad, Martin

“…Atrial myocytes, lacking t-tubules, have two functionally separate groups of ryanodine receptors (RyRs): those at the periphery colocalized with…”
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Ca2+ current-gated focal and local ca2+ release in rat atrial myocytes: evidence from rapid 2-d confocal imaging by Woo, Sun‐Hee, Cleemann, Lars, Morad, Martin

“…In atrial myocytes immunocytochemistry has shown two groups of ryanodine receptors (RyRs): those at the periphery colocalized with dihydropyridine receptors…”
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Two-Dimensional Confocal Images of Organization, Density, and Gating of Focal Ca2+Release Sites in Rat Cardiac Myocytes by Cleemann, Lars, Wang, Wei, Morad, Martin

“…In cardiac myocytes Ca2+cross-signaling between Ca2+channels and ryanodine receptors takes place by exchange of Ca2+signals in microdomains surrounding dyadic…”
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Gender difference in the cycle length-dependent QT and potassium currents in rabbits by Liu, X K, Katchman, A, Drici, M D, Ebert, S N, Ducic, I, Morad, M, Woosley, R L

“…Women are known to have a longer electrocardiographic Q-T than men, which may contribute to their being at greater risk of developing drug-induced polymorphic…”
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Ca2+ signaling of human pluripotent stem cells-derived cardiomyocytes as compared to adult mammalian cardiomyocytes by Zhang, Xiao-hua, Morad, Martin

“…[Display omitted] •Functional comparison of Ca2+ signaling parameters in hiPSC-CMs and adult mammalian cardiomyocytes.•Ca2+ signaling of hiPSC-CMs as a model…”
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Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin by Knollmann, Björn C., Knollmann‐Ritschel, Barbara E. C., Weissman, Neil J., Jones, Larry R., Morad, Martin

“…Overexpression of cardiac calsequestrin (CSQ) impairs Ca 2+ signalling in murine myocytes, leading to marked cardiac hypertrophy. Here we report on…”
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Multimodality of Ca2+ Signaling in Rat Atrial Myocytes by MORAD, MARTIN, JAVAHERI, ASHKAN, RISIUS, TIM, BELMONTE, STEVE

“…: It has been suggested that the multiplicity of Ca2+ signaling pathways in atrial myocytes may contribute to the variability of its function. This article…”
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Inotropic Stimulation Induces Cardiac Dysfunction in Transgenic Mice Expressing a Troponin T (I79N) Mutation Linked to Familial Hypertrophic Cardiomyopathy by Knollmann, Björn C., Blatt, Stephen A., Horton, Kenneth, de Freitas, Fatima, Miller, Todd, Bell, Michael, Housmans, Philippe R., Weissman, Neil J., Morad, Martin, Potter, James D.

“…The cardiac troponin T (TnT) I79N mutation has been linked to familial hypertrophic cardiomyopathy and a high incidence of sudden death, despite causing little…”
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Point mutations in RyR2 Ca2+-binding residues of human cardiomyocytes cause cellular remodelling of cardiac excitation contraction-coupling by Xia, Yanli, Zhang, Xiao-hua, Yamaguchi, Naohiro, Morad, Martin

“…Abstract Aims CRISPR/Cas9 gene edits of cardiac ryanodine receptor (RyR2) in human-induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) provide a…”
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Synaptic Acidification Enhances GABA A Signaling by Dietrich, Craig J., Morad, Martin

“…To determine the role of cellularly generated protons in synaptic signaling, we recorded GABA miniature IPSCs (mIPSCs) from cultured rat cerebellar granule…”
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