Search Results - "Mora, Ana L"

Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis by Mora, Ana L, Bueno, Marta, Rojas, Mauricio

“…Idiopathic pulmonary fibrosis (IPF) is a chronic age-related lung disease with high mortality that is characterized by abnormal scarring of the lung…”
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Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease by Mora, Ana L., Rojas, Mauricio, Pardo, Annie, Selman, Moises

“…Key Points Idiopathic pulmonary fibrosis (IPF) is a chronic lethal lung disease, the prevalence and incidence of which dramatically increase with age. Novel…”
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Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis by Bueno, Marta, Calyeca, Jazmin, Rojas, Mauricio, Mora, Ana L.

“…Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology. It is characterized by deposition of extracellular matrix proteins, like…”
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IPF lung fibroblasts have a senescent phenotype by Álvarez, Diana, Cárdenes, Nayra, Sellarés, Jacobo, Bueno, Marta, Corey, Catherine, Hanumanthu, Vidya Sagar, Peng, Yating, D'Cunha, Hannah, Sembrat, John, Nouraie, Mehdi, Shanker, Swaroop, Caufield, Chandler, Shiva, Sruti, Armanios, Mary, Mora, Ana L, Rojas, Mauricio

“…The mechanisms of aging that are involved in the development of idiopathic pulmonary fibrosis (IPF) are still unclear. Although it has been hypothesized that…”
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Idiopathic Pulmonary Fibrosis: Aging, Mitochondrial Dysfunction, and Cellular Bioenergetics by Zank, Daniel C, Bueno, Marta, Mora, Ana L, Rojas, Mauricio

“…At present, the etiology of idiopathic pulmonary fibrosis (IPF) remains elusive. Over the past two decades, however, researchers have identified and described…”
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PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses by Bueno, Marta, Zank, Daniel, Buendia-Roldán, Ivette, Fiedler, Kaitlin, Mays, Brenton G, Alvarez, Diana, Sembrat, John, Kimball, Brian, Bullock, Jordan K, Martin, James L, Nouraie, Mehdi, Kaufman, Brett A, Rojas, Mauricio, Pardo, Annie, Selman, Moisés, Mora, Ana L

“…We have previously shown that endoplasmic reticulum stress (ER stress) represses the PTEN inducible kinase 1 (PINK1) in lung type II alveolar epithelial cells…”
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Aging Mesenchymal Stem Cells Fail to Protect Because of Impaired Migration and Antiinflammatory Response by BUSTOS, Martha L, HULEIHEL, Luai, MORA, Ana L, ROJAS, Mauricio, KAPETANAKI, Maria G, LINO-CARDENAS, Christian L, MROZ, Lyle, ELLIS, Bryon M, MCVERRY, Bryan J, RICHARDS, Thomas J, KAMINSKI, Naftali, CERDENES, Nayra

“…Aging is characterized by functional impairment and reduced capacity to respond appropriately to environmental stimuli and injury. With age, there is an…”
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Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis by Cárdenes, Nayra, Álvarez, Diana, Sellarés, Jacobo, Peng, Yating, Corey, Catherine, Wecht, Sophie, Nouraie, Seyed Mehdi, Shanker, Swaroop, Sembrat, John, Bueno, Marta, Shiva, Sruti, Mora, Ana L, Rojas, Mauricio

“…Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease for which age is the most important risk factor. Different mechanisms associated with aging,…”
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Influence of age on wound healing and fibrosis by Kapetanaki, Maria G, Mora, Ana L, Rojas, Mauricio

“…The incidence and severity of fibrotic lung diseases increase with age, but very little is known about how age‐related changes affect the mechanisms that…”
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Pharmacological Inhibition of mTOR Kinase Reverses Right Ventricle Remodeling and Improves Right Ventricle Structure and Function in Rats by Pena, Andressa, Kobir, Ahasanul, Goncharov, Dmitry, Goda, Akiko, Kudryashova, Tatiana V, Ray, Arnab, Vanderpool, Rebecca, Baust, Jeffrey, Chang, Baojun, Mora, Ana L, Gorcsan, 3rd, John, Goncharova, Elena A

“…Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling, increased pulmonary artery (PA) pressure, right-heart afterload and…”
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Early events marking lung fibroblast transition to profibrotic state in idiopathic pulmonary fibrosis by Jia, Minxue, Rosas, Lorena, Kapetanaki, Maria G, Tabib, Tracy, Sebrat, John, Cruz, Tamara, Bondonese, Anna, Mora, Ana L, Lafyatis, Robert, Rojas, Mauricio, Benos, Panayiotis V

“…Idiopathic Pulmonary Fibrosis (IPF) is an age-associated progressive lung disease with accumulation of scar tissue impairing gas exchange. Previous…”
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Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival by Kudryashova, Tatiana V., Dabral, Swati, Nayakanti, Sreenath, Ray, Arnab, Goncharov, Dmitry A., Avolio, Theodore, Shen, Yuanjun, Rode, Analise, Pena, Andressa, Jiang, Lifeng, Lin, Derek, Baust, Jeffrey, Bachman, Timothy N., Graumann, Johannes, Ruppert, Clemens, Guenther, Andreas, Schmoranzer, Mario, Grobs, Yann, Eve Lemay, Sarah, Tremblay, Eve, Breuils-Bonnet, Sandra, Boucherat, Olivier, Mora, Ana L., DeLisser, Horace, Zhao, Jing, Zhao, Yutong, Bonnet, Sébastien, Seeger, Werner, Pullamsetti, Soni S., Goncharova, Elena A.

“…The MSTs (mammalian Ste20-like kinases) 1/2 are members of the HIPPO pathway that act as growth suppressors in adult proliferative diseases. Pulmonary arterial…”
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Bone Marrow-Derived Mesenchymal Stem Cells in Repair of the Injured Lung by Rojas, Mauricio, Xu, Jianguo, Woods, Charles R, Mora, Ana L, Spears, Willy, Roman, Jesse, Brigham, Kenneth L

“…We sought to determine whether an intact bone marrow is essential to lung repair following bleomycin-induced lung injury in mice, and the mechanisms of any…”
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Loss of MT1-MMP in Alveolar Epithelial Cells Exacerbates Pulmonary Fibrosis by Placido, Luis, Romero, Yair, Maldonado, Mariel, Toscano-Marquez, Fernanda, Ramírez, Remedios, Calyeca, Jazmín, Mora, Ana L, Selman, Moisés, Pardo, Annie

“…Idiopathic pulmonary fibrosis (IPF) is a lethal age-related lung disease whose pathogenesis involves an aberrant response of alveolar epithelial cells (AEC)…”
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Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis by Pozharskaya, Veronika, Torres-González, Edilson, Rojas, Mauricio, Gal, Anthony, Amin, Minal, Dollard, Sheila, Roman, Jesse, Stecenko, Arlene A, Mora, Ana L

“…Several studies have implicated viral infection as an important factor in the pathogenesis of IPF and related fibrotic lung disorders. Viruses are thought to…”
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FAM13A, A Fatty Acid Oxidation Switch in Mitochondria. Friend or Foe in Chronic Obstructive Pulmonary Disease Pathogenesis? by Hawkins, Gregory A, Mora, Ana L

“…[...]all significant associations in FAM13A have been found in noncoding regions of the gene. In 2014, further insight was provided by Kim and colleagues, who…”
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Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice by Xu, Jianguo, Woods, Charles R, Mora, Ana L, Joodi, Robert, Brigham, Kenneth L, Iyer, Smita, Rojas, Mauricio

“…Bone marrow-derived mesenchymal stem cells (BMDMSCs) appear to be important in repair of the chronic lung injury caused by bleomycin in mice. To determine…”
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Aging and Lung Disease. Clinical Impact and Cellular and Molecular Pathways by Rojas, Mauricio, Mora, Ana L, Kapetanaki, Maria, Weathington, Nathaniel, Gladwin, Mark, Eickelberg, Oliver

“…With the expected rapid growth of the aging population worldwide, there is a clear need to understand the complex process of aging to develop interventions…”
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Interferon Lambda Signaling in Macrophages Is Necessary for the Antiviral Response to Influenza by Mallampalli, Rama K, Adair, Jessica, Elhance, Ajit, Farkas, Daniela, Chafin, Lexie, Long, Matthew E, De, Mithu, Mora, Ana L, Rojas, Mauricio, Peters, Victor, Bednash, Joseph S, Tsai, MuChun, Londino, James D

“…Interferon lambda (IFNλ) signaling is a promising therapeutic target against viral infection in murine models, yet little is known about its molecular…”
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TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction by Rogers, Natasha M, Sharifi-Sanjani, Maryam, Yao, Mingyi, Ghimire, Kedar, Bienes-Martinez, Raquel, Mutchler, Stephanie M, Knupp, Heather E, Baust, Jeffrey, Novelli, Enrico M, Ross, Mark, St Croix, Claudette, Kutten, Johannes C, Czajka, Caitlin A, Sembrat, John C, Rojas, Mauricio, Labrousse-Arias, David, Bachman, Timothy N, Vanderpool, Rebecca R, Zuckerbraun, Brian S, Champion, Hunter C, Mora, Ana L, Straub, Adam C, Bilonick, Richard A, Calzada, Maria J, Isenberg, Jeffrey S

“…Thrombospondin-1 (TSP1) is a ligand for CD47 and TSP1 mice are protected from pulmonary hypertension (PH). We hypothesized the TSP1-CD47 axis is upregulated in…”
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