Search Results - "Moparthy, Kalyana C"

KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells by Mannava, Sudha, Zhuang, DaZhong, Nair, Jayakumar R., Bansal, Rajat, Wawrzyniak, Joseph A., Zucker, Shoshanna N., Fink, Emily E., Moparthy, Kalyana C., Hu, Qiang, Liu, Song, Boise, Lawrence H., Lee, Kelvin P., Nikiforov, Mikhail A.

“…Bortezomib, a therapeutic agent for multiple myeloma (MM) and mantle cell lymphoma, suppresses proteosomal degradation leading to substantial changes in…”
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A Purine Nucleotide Biosynthesis Enzyme Guanosine Monophosphate Reductase Is a Suppressor of Melanoma Invasion by Wawrzyniak, Joseph A., Bianchi-Smiraglia, Anna, Bshara, Wiam, Mannava, Sudha, Ackroyd, Jeff, Bagati, Archis, Omilian, Angela R., Im, Michael, Fedtsova, Natalia, Miecznikowski, Jeffrey C., Moparthy, Kalyana C., Zucker, Shoshanna N., Zhu, Qianqian, Kozlova, Nadezhda I., Berman, Albert E., Hoek, Keith S., Gudkov, Andrei V., Shewach, Donna S., Morrison, Carl D., Nikiforov, Mikhail A.

“…Melanoma is one of the most aggressive types of human cancers, and the mechanisms underlying melanoma invasive phenotype are not completely understood. Here,…”
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Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence by Mannava, Sudha, Moparthy, Kalyana C, Wheeler, Linda J, Natarajan, Venkatesh, Zucker, Shoshanna N, Fink, Emily E, Im, Michael, Flanagan, Sheryl, Burhans, William C, Zeitouni, Nathalie C, Shewach, Donna S, Mathews, Christopher K, Nikiforov, Mikhail A

“…In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response. Oxidative stress and hyperreplication of genomic DNA have…”
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Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion by Mannava, Sudha, Moparthy, Kalyana C, Wheeler, Linda J, Leonova, Katerina I, Wawrzyniak, Joseph A, Bianchi-Smiraglia, Anna, Berman, Albert E, Flanagan, Sheryl, Shewach, Donna S, Zeitouni, Nathalie C, Gudkov, Andrei V, Mathews, Christopher K, Nikiforov, Mikhail A

“…The down-regulation of dominant oncogenes, including C-MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely…”
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