Search Results - "Moots, Robert"

The multifactorial role of neutrophils in rheumatoid arthritis by Wright, Helen L., Moots, Robert J., Edwards, Steven W.

“…Key Points Neutrophils contribute to rheumatoid arthritis (RA) pathology through the release of cytotoxic and immunoregulatory molecules Neutrophils from…”
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Rheumatoid Arthritis Synovial Fluid Neutrophils Drive Inflammation Through Production of Chemokines, Reactive Oxygen Species, and Neutrophil Extracellular Traps by Wright, Helen L, Lyon, Max, Chapman, Elinor A, Moots, Robert J, Edwards, Steven W

“…Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting synovial joints. Neutrophils are believed to play an important role in both the…”
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The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies by McGonagle, Dennis G, McInnes, Iain B, Kirkham, Bruce W, Sherlock, Jonathan, Moots, Robert

“…Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence…”
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Prevalence and impact of comorbidities in axial spondyloarthritis: systematic review and meta-analysis by Zhao, Sizheng Steven, Robertson, Selina, Reich, Tzvi, Harrison, Nicolas L, Moots, Robert J, Goodson, Nicola J

“…Abstract Objectives Comorbidities are common in people with axial spondyloarthritis (axSpA). In this systematic review and meta-analysis, we aimed to: (i)…”
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Etanercept for the treatment of rheumatoid arthritis by Zhao, Sizheng, Mysler, Eduardo, Moots, Robert J

“…Etanercept was the first specific anticytokine therapy approved for the treatment of rheumatoid arthritis (RA). Its clinical efficacy and safety has been…”
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The impact of anti-drug antibodies on drug concentrations and clinical outcomes in rheumatoid arthritis patients treated with adalimumab, etanercept, or infliximab: Results from a multinational, real-world clinical practice, non-interventional study by Moots, Robert J, Xavier, Ricardo M, Mok, Chi Chiu, Rahman, Mahboob U, Tsai, Wen-Chan, Al-Maini, Mustafa H, Pavelka, Karel, Mahgoub, Ehab, Kotak, Sameer, Korth-Bradley, Joan, Pedersen, Ron, Mele, Linda, Shen, Qi, Vlahos, Bonnie

“…To assess the incidence of anti-drug antibodies (ADA) in patients with rheumatoid arthritis (RA) treated with the TNF inhibitors etanercept (ETN), adalimumab…”
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Caught in a Trap? Proteomic Analysis of Neutrophil Extracellular Traps in Rheumatoid Arthritis and Systemic Lupus Erythematosus by Chapman, Elinor A, Lyon, Max, Simpson, Deborah, Mason, David, Beynon, Robert J, Moots, Robert J, Wright, Helen L

“…Neutrophil Extracellular Traps (NETs) are implicated in the development of auto-immunity in diseases such as rheumatoid arthritis (RA) and systemic lupus…”
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Safety and efficacy of subcutaneous ianalumab (VAY736) in patients with primary Sjögren's syndrome: a randomised, double-blind, placebo-controlled, phase 2b dose-finding trial by Bowman, Simon J, Fox, Robert, Dörner, Thomas, Mariette, Xavier, Papas, Athena, Grader-Beck, Thomas, Fisher, Benjamin A, Barcelos, Filipe, De Vita, Salvatore, Schulze-Koops, Hendrik, Moots, Robert J, Junge, Guido, Woznicki, Janice N, Sopala, Monika A, Luo, Wen-Lin, Hueber, Wolfgang

“…Sjögren's syndrome is an autoimmune disease characterised by dry eyes and mouth, systemic features, and reduced quality of life. There are no disease-modifying…”
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Cutaneous signs of rheumatic diseases in skin of colour: are we failing our patients? by Haddad, Jonathan, Coulson, Ian, Oyoo, G Omondi, Moots, Robert J

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RNA-seq reveals activation of both common and cytokine-specific pathways following neutrophil priming by Wright, Helen L, Thomas, Huw B, Moots, Robert J, Edwards, Steven W

“…Neutrophils are central to the pathology of inflammatory diseases, where they can damage host tissue through release of reactive oxygen metabolites and…”
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Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo by Wright, Helen L, Cross, Andrew L, Edwards, Steven W, Moots, Robert J

“…Reports on the regulation of neutrophil function by IL-6 are often conflicting. Therapeutic inhibition of IL-6 in RA is associated with occasional neutropenia,…”
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Low‐density granulocytes: functionally distinct, immature neutrophils in rheumatoid arthritis with altered properties and defective TNF signalling by Wright, Helen L., Makki, Fatima A., Moots, Robert J., Edwards, Steven W.

“…Our aim was to determine whether rheumatoid arthritis (RA) low‐density granulocytes (LDGs) are functionally different from RA neutrophils. LDGs from 32 RA…”
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Review of Biosimilar Trials and Data on Adalimumab in Rheumatoid Arthritis by Zhao, Sizheng, Chadwick, Laura, Mysler, Eduardo, Moots, Robert J.

“…Purpose of Review Adalimumab is one of the top-selling drugs worldwide. Its imminent patent expiration has seen the emergence of numerous biosimilar agents. In…”
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Randomized Controlled Trial of Rituximab and Cost‐Effectiveness Analysis in Treating Fatigue and Oral Dryness in Primary Sjögren's Syndrome by Bowman, Simon J., Everett, Colin C., O'Dwyer, John L., Emery, Paul, Pitzalis, Costantino, Ng, Wan‐Fai, Pease, Colin T., Price, Elizabeth J., Sutcliffe, Nurhan, Gendi, Nagui S. T., Hall, Frances C., Ruddock, Sharon P., Fernandez, Catherine, Reynolds, Catherine, Hulme, Claire T., Davies, Kevin A., Edwards, Christopher J., Lanyon, Peter C., Moots, Robert J., Roussou, Euthalia, Giles, Ian P., Sharples, Linda D., Bombardieri, Michele

“…Objective To investigate whether rituximab, an anti–B cell therapy, improves symptoms of fatigue and oral dryness in patients with primary Sjögren's syndrome…”
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Behcet’s disease by Nair, Jagdish R, Moots, Robert J

“…Behçet’s disease (BD) is a chronic relapsing and remitting vasculitis of unknown aetiology. It has the capacity to affect almost all organ systems because of…”
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2018 update of the EULAR recommendations for the management of Behçet's syndrome by Hatemi, Gulen, Christensen, Robin, Bang, Dongsik, Bodaghi, Bahram, Celik, Aykut Ferhat, Fortune, Farida, Gaudric, Julien, Gul, Ahmet, Kötter, Ina, Leccese, Pietro, Mahr, Alfred, Moots, Robert, Ozguler, Yesim, Richter, Jutta, Saadoun, David, Salvarani, Carlo, Scuderi, Francesco, Sfikakis, Petros P, Siva, Aksel, Stanford, Miles, Tugal-Tutkun, Ilknur, West, Richard, Yurdakul, Sebahattin, Olivieri, Ignazio, Yazici, Hasan

“…Several new treatment modalities with different mechanisms of action have been studied in patients with Behçet's syndrome (BS). The aim of the current effort…”
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Neutrophil biomarkers predict response to therapy with tumor necrosis factor inhibitors in rheumatoid arthritis by Wright, Helen L., Cox, Trevor, Moots, Robert J., Edwards, Steven W.

“…A set of 23 neutrophil‐derived gene biomarkers can predict response to TNF inhibitors in patients with RA. Neutrophils are implicated in the pathology of…”
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Anti-TNF biosimilars in rheumatology: the end of an era? by Dey, Mrinalini, Zhao, Sizheng Steven, Moots, Robert J

“…Tumor necrosis factor inhibitors (TNFi) have revolutionized the treatment of rheumatic diseases. Whilst extremely efficacious, the original TNFi also carried a…”
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Review of Biosimilar Trials and Data on Etanercept in Rheumatoid Arthritis by Chadwick, Laura, Zhao, Sizheng, Mysler, Eduardo, Moots, Robert J.

“…Purpose of Review Etanercept was the first tumour necrosis factor inhibitor approved to treat rheumatoid arthritis (RA) in the United States (US) and Europe…”
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Neutrophil function in inflammation and inflammatory diseases by Wright, Helen L., Moots, Robert J., Bucknall, Roger C., Edwards, Steven W.

“…In inflammatory conditions such as RA, the neutrophil has tended to be dismissed as a short-lived, terminally differentiated, irrelevant bystander cell…”
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