Search Results - "Moors, Tim E."

Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease by Moors, Tim E., Hoozemans, Jeroen J. M., Ingrassia, Angela, Beccari, Tommaso, Parnetti, Lucilla, Chartier-Harlin, Marie-Christine, van de Berg, Wilma D. J.

“…Converging evidence from genetic, pathological and experimental studies have increasingly suggested an important role for autophagy impairment in Parkinson's…”
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Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity by Ramalingam, Nagendran, Jin, Shan-Xue, Moors, Tim E., Fonseca-Ornelas, Luis, Shimanaka, Kazuma, Lei, Shi, Cam, Hugh P., Watson, Aurelia Hays, Brontesi, Lisa, Ding, Lai, Hacibaloglu, Dinc Yasat, Jiang, Haiyang, Choi, Se Joon, Kanter, Ellen, Liu, Lei, Bartels, Tim, Nuber, Silke, Sulzer, David, Mosharov, Eugene V., Chen, Weisheng V., Li, Shaomin, Selkoe, Dennis J., Dettmer, Ulf

“…In Parkinson’s disease and other synucleinopathies, the elevation of α-synuclein phosphorylated at Serine129 (pS129) is a widely cited marker of pathology…”
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Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies by Moors, Tim E, Mona, Daniel, Luehe, Stefan, Duran-Pacheco, Gonzalo, Spycher, Liz, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N, Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Dernick, Gregor, van de Berg, Wilma D J, Britschgi, Markus

“…Based on immunostainings and biochemical analyses, certain post-translationally modified alpha-synuclein (aSyn) variants, including C-terminally truncated…”
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Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes by Nuber, Silke, Zhang, Xiaoqun, McCaffery, Thomas D., Moors, Tim E., Adom, Marie-Alexandre, Hahn, Wolf N., Martin, Dylan, Ericsson, Maria, Tripathi, Arati, Dettmer, Ulf, Svenningsson, Per, Selkoe, Dennis J.

“…Mutations in the α-Synuclein (αS) gene promote αS monomer aggregation that causes neurodegeneration in familial Parkinson’s disease (fPD). However, most mouse…”
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Author Correction: Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes by Nuber, Silke, Zhang, Xiaoqun, McCaffery, Thomas D., Moors, Tim E., Adom, Marie-Alexandre, Hahn, Wolf N., Martin, Dylan, Ericsson, Maria, Tripathi, Arati, Dettmer, Ulf, Svenningsson, Per, Selkoe, Dennis J.

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Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes by Shahmoradian, Sarah H., Lewis, Amanda J., Genoud, Christel, Hench, Jürgen, Moors, Tim E., Navarro, Paula P., Castaño-Díez, Daniel, Schweighauser, Gabriel, Graff-Meyer, Alexandra, Goldie, Kenneth N., Sütterlin, Rosmarie, Huisman, Evelien, Ingrassia, Angela, Gier, Yvonne de, Rozemuller, Annemieke J. M., Wang, Jing, Paepe, Anne De, Erny, Johannes, Staempfli, Andreas, Hoernschemeyer, Joerg, Großerüschkamp, Frederik, Niedieker, Daniel, El-Mashtoly, Samir F., Quadri, Marialuisa, Van IJcken, Wilfred F. J., Bonifati, Vincenzo, Gerwert, Klaus, Bohrmann, Bernd, Frank, Stephan, Britschgi, Markus, Stahlberg, Henning, Van de Berg, Wilma D. J., Lauer, Matthias E.

“…Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological…”
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Therapeutic potential of autophagy-enhancing agents in Parkinson's disease by Moors, Tim E, Hoozemans, Jeroen J M, Ingrassia, Angela, Beccari, Tommaso, Parnetti, Lucilla, Chartier-Harlin, Marie-Christine, van de Berg, Wilma D J

“…Converging evidence from genetic, pathological and experimental studies have increasingly suggested an important role for autophagy impairment in Parkinson's…”
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Defining a Lewy Body: Running Up the Hill of Shifting Definitions and Evolving Concepts by Moors, Tim E., Milovanovic, Dragomir

“…Lewy bodies (LBs) are pathological hallmarks of Parkinson’s disease and dementia with Lewy bodies, characterized by the accumulation of α-synuclein (αSyn)…”
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Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson’s Disease and Dementia with Lewy Bodies by Moors, Tim E., Paciotti, Silvia, Ingrassia, Angela, Quadri, Marialuisa, Breedveld, Guido, Tasegian, Anna, Chiasserini, Davide, Eusebi, Paolo, Duran-Pacheco, Gonzalo, Kremer, Thomas, Calabresi, Paolo, Bonifati, Vincenzo, Parnetti, Lucilla, Beccari, Tommaso, van de Berg, Wilma D. J.

“…Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson’s disease…”
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The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy by Moors, Tim E., Maat, Christina A., Niedieker, Daniel, Mona, Daniel, Petersen, Dennis, Timmermans-Huisman, Evelien, Kole, Jeroen, El-Mashtoly, Samir F., Spycher, Liz, Zago, Wagner, Barbour, Robin, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N., Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Geurts, Jeroen J. G., Gerwert, Klaus, Britschgi, Markus, van de Berg, Wilma D. J.

“…Various post-translationally modified (PTM) proteoforms of alpha-synuclein (aSyn)—including C-terminally truncated (CTT) and Serine 129 phosphorylated…”
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Wild-type GBA1 increases the α-synuclein tetramer–monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice by Glajch, Kelly E., Moors, Tim E., Chen, Yi, Bechade, Pascal A., Nam, Alice Y., Rajsombath, Molly M., McCaffery, Thomas D., Dettmer, Ulf, Weihofen, Andreas, Hirst, Warren D., Selkoe, Dennis J., Nuber, Silke

“…Loss-of-function mutations in acid beta-glucosidase 1 (GBA1) are among the strongest genetic risk factors for Lewy body disorders such as Parkinson’s disease…”
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Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases by Moors, Tim E., Morella, Martino L., Bertran-Cobo, Cesc, Geut, Hanneke, Udayar, Vinod, Timmermans-Huisman, Evelien, Ingrassia, Angela M. T., Brevé, John J. P., Bol, John G. J. M., Bonifati, Vincenzo, Jagasia, Ravi, van de Berg, Wilma D. J.

“…Transcription factor EB (TFEB) is a master regulator of genes involved in the maintenance of autophagic and lysosomal homeostasis, processes which have been…”
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Increased palmitoylation improves estrogen receptor alpha-dependent hippocampal synaptic deficits in a mouse model of synucleinopathy by Moors, Tim E, Li, Shaomin, McCaffery, Thomas D, Ho, Gary P H, Bechade, Pascal A, Pham, Luu N, Ericsson, Maria, Nuber, Silke

“…Parkinson's disease (PD) is characterized by conversion of soluble α-synuclein (αS) into intraneuronal aggregates and degeneration of neurons and neuronal…”
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