Search Results - "Moorman, Jonathan P."

Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells by Wang, Ling, Lu, Zeyuan, Zhao, Juan, Schank, Madison, Cao, Dechao, Dang, Xindi, Nguyen, Lam Nhat, Nguyen, Lam Ngoc Thao, Khanal, Sushant, Zhang, Jinyu, Wu, Xiao Y., El Gazzar, Mohamed, Ning, Shunbin, Moorman, Jonathan P., Yao, Zhi Q.

“…Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere erosion and mitochondrial injury, leading to impaired cellular functions…”
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The Impact of HIV- and ART-Induced Mitochondrial Dysfunction in Cellular Senescence and Aging by Schank, Madison, Zhao, Juan, Moorman, Jonathan P, Yao, Zhi Q

“…According to the WHO, 38 million individuals were living with human immunodeficiency virus (HIV), 25.4 million of which were using antiretroviral therapy (ART)…”
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Trained Immunity: An Overview and the Impact on COVID-19 by Brueggeman, Justin M, Zhao, Juan, Schank, Madison, Yao, Zhi Q, Moorman, Jonathan P

“…Effectively treating infectious diseases often requires a multi-step approach to target different components involved in disease pathogenesis. Similarly, the…”
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PKIB, a Novel Target for Cancer Therapy by Musket, Anna, Moorman, Jonathan P, Zhang, Jinyu, Jiang, Yong

“…The serine-threonine kinase protein kinase A (PKA) is a cyclic AMP (cAMP)-dependent intracellular protein with multiple roles in cellular biology including…”
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Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ monocytes by Zhang, Ying, Ma, Cheng J., Wang, Jia M., Ji, Xiao J., Wu, Xiao Y., Moorman, Jonathan P., Yao, Zhi Q.

“…Regulation of pro‐ and anti‐inflammatory innate immune responses by Tim‐3 in macrophages. Tim‐3 and PD‐1 are powerful immunoinhibitory molecules involved in…”
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ROS-Induced Mitochondrial Dysfunction in CD4 T Cells from ART-Controlled People Living with HIV by Schank, Madison, Zhao, Juan, Wang, Ling, Nguyen, Lam Ngoc Thao, Zhang, Yi, Wu, Xiao Y, Zhang, Jinyu, Jiang, Yong, Ning, Shunbin, El Gazzar, Mohamed, Moorman, Jonathan P, Yao, Zhi Q

“…We have previously demonstrated mitochondrial dysfunction in aging CD4 T cells from antiretroviral therapy (ART)-controlled people living with HIV (PLWH)…”
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p62-mediated Selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress by Wang, Ling, Howell, Mary E A, Sparks-Wallace, Ayrianna, Hawkins, Caroline, Nicksic, Camri A, Kohne, Carissa, Hall, Kenton H, Moorman, Jonathan P, Yao, Zhi Q, Ning, Shunbin

“…DNA damage response (DDR) and selective autophagy both can be activated by reactive oxygen/nitrogen species (ROS/RNS), and both are of paramount importance in…”
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Gene expression profiling identifies IRF4-associated molecular signatures in hematological malignancies by Wang, Ling, Yao, Zhi Q, Moorman, Jonathan P, Xu, Yanji, Ning, Shunbin

“…The lymphocyte-specific transcription factor Interferon (IFN) Regulatory Factor 4 (IRF4) is implicated in certain types of lymphoid and myeloid malignancies…”
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Long Non-coding RNA GAS5 Regulates T Cell Functions via miR21-Mediated Signaling in People Living With HIV by Nguyen, Lam Ngoc Thao, Nguyen, Lam Nhat, Zhao, Juan, Schank, Madison, Dang, Xindi, Cao, Dechao, Khanal, Sushant, Chand Thakuri, Bal Krishna, Lu, Zeyuan, Zhang, Jinyu, Li, Zhengke, Morrison, Zheng D, Wu, Xiao Y, El Gazzar, Mohamed, Ning, Shunbin, Wang, Ling, Moorman, Jonathan P, Yao, Zhi Q

“…T cells are critical for the control of viral infections and T cell responses are regulated by a dynamic network of non-coding RNAs, including microRNAs (miR)…”
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LncRNA HOTAIRM1 promotes MDSC expansion and suppressive functions through the HOXA1-miR124 axis during HCV infection by Thakuri, Bal Krishna Chand, Zhang, Jinyu, Zhao, Juan, Nguyen, Lam N., Nguyen, Lam N. T., Khanal, Sushant, Cao, Dechao, Dang, Xindi, Schank, Madison, Wu, Xiao Y., Morrison, Zheng D., Gazzar, Mohamed El, Li, Zhengke, Jiang, Yong, Ning, Shunbin, Wang, Ling, Moorman, Jonathan P., Yao, Zhi Q.

“…HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is a long non-coding RNA (lncRNA) that plays a pivotal role in regulating myeloid cell development…”
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Mitochondrial Functions Are Compromised in CD4 T Cells From ART-Controlled PLHIV by Zhao, Juan, Schank, Madison, Wang, Ling, Li, Zhengke, Nguyen, Lam Nhat, Dang, Xindi, Cao, Dechao, Khanal, Sushant, Nguyen, Lam Ngoc Thao, Thakuri, Bal Krishna Chand, Ogbu, Stella C, Lu, Zeyuan, Wu, Xiao Y, Morrison, Zheng D, Gazzar, Mohamed El, Liu, Ying, Zhang, Jinyu, Ning, Shunbin, Moorman, Jonathan P, Yao, Zhi Q

“…The hallmark of HIV/AIDS is a gradual depletion of CD4 T cells. Despite effective control by antiretroviral therapy (ART), a significant subgroup of people…”
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Blockade of SARS-CoV-2 spike protein-mediated cell–cell fusion using COVID-19 convalescent plasma by Wang, Ling, Zhao, Juan, Nguyen, Lam N. T., Adkins, James L., Schank, Madison, Khanal, Sushant, Nguyen, Lam N., Dang, Xindi, Cao, Dechao, Thakuri, Bal Krishna Chand, Lu, Zeyuan, Zhang, Jinyu, Zhang, Yi, Wu, Xiao Y., El Gazzar, Mohamed, Ning, Shunbin, Moorman, Jonathan P., Yao, Zhi Q.

“…The recent COVID-19 pandemic poses a serious threat to global public health, thus there is an urgent need to define the molecular mechanisms involved in…”
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A Matter of Life or Death: Productively Infected and Bystander CD4 T Cells in Early HIV Infection by Cao, Dechao, Khanal, Sushant, Wang, Ling, Li, Zhengke, Zhao, Juan, Nguyen, Lam Nhat, Nguyen, Lam Ngoc Thao, Dang, Xindi, Schank, Madison, Thakuri, Bal Krishna Chand, Zhang, Jinyu, Lu, Zeyuan, Wu, Xiao Y, Morrison, Zheng D, El Gazzar, Mohamed, Ning, Shunbin, Moorman, Jonathan P, Yao, Zhi Q

“…CD4 T cell death or survival following initial HIV infection is crucial for the development of viral reservoirs and latent infection, making its evaluation…”
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HIV-1 Latency and Viral Reservoirs: Existing Reversal Approaches and Potential Technologies, Targets, and Pathways Involved in HIV Latency Studies by Khanal, Sushant, Schank, Madison, El Gazzar, Mohamed, Moorman, Jonathan P, Yao, Zhi Q

“…Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Reactivation of HIV latency and killing of virus-infected…”
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The sex specific effect of alcohol consumption on circulating levels of CTRP3 by DeGroat, Ashley R, Fleming, Christina K, Dunlay, Samantha M, Hagood, Kendra L, Moorman, Jonathan P, Peterson, Jonathan M

“…The goal of this project was to establish the effect of alcohol consumption on the circulating levels of the adipose tissue derived protein C1q TNF Related…”
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ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy by Zhao, Juan, Nguyen, Lam Ngoc Thao, Nguyen, Lam Nhat, Dang, Xindi, Cao, Dechao, Khanal, Sushant, Schank, Madison, Thakuri, Bal Krishna Chand, Ogbu, Stella C, Morrison, Zheng D, Wu, Xiao Y, Li, Zhengke, Zou, Yue, El Gazzar, Mohamed, Ning, Shunbin, Wang, Ling, Moorman, Jonathan P, Yao, Zhi Q

“…HIV infection leads to a phenomenon of inflammaging, in which chronic inflammation induces an immune aged phenotype, even in individuals on combined…”
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Tim-3 negatively regulates IL-12 expression by monocytes in HCV infection by Zhang, Ying, Ma, Cheng J, Wang, Jia M, Ji, Xiao J, Wu, Xiao Y, Jia, Zhan S, Moorman, Jonathan P, Yao, Zhi Q

“…T cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is a newly identified negative immunomodulator that is up-regulated on dysfunctional T…”
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Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection by Zhang, Ying, Ma, Cheng J, Ni, Lei, Zhang, Chun L, Wu, Xiao Y, Kumaraguru, Uday, Li, Chuan F, Moorman, Jonathan P, Yao, Zhi Q

“…Hepatitis C virus (HCV) dysregulates innate immune responses and induces persistent viral infection. We previously demonstrated that HCV core protein impairs…”
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Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions by Cao, Dechao, Zhao, Juan, Nguyan, Lam N, Nguyen, Lam N T, Khanal, Sushant, Dang, Xindi, Schank, Madison, Chand Thakuri, Bal K, Wu, Xiao Y, Morrison, Zheng D, El Gazzar, Mohamed, Zou, Yue, Ning, Shunbin, Wang, Ling, Moorman, Jonathan P, Yao, Zhi Q

“…T cells in chronic viral infections are featured by premature aging with accelerated telomere erosion, but the mechanisms underlying telomere attrition remain…”
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Oxidative Stress Induces Mitochondrial Compromise in CD4 T Cells From Chronically HCV-Infected Individuals by Schank, Madison, Zhao, Juan, Wang, Ling, Nguyen, Lam Ngoc Thao, Cao, Dechao, Dang, Xindi, Khanal, Sushant, Zhang, Jinyu, Zhang, Yi, Wu, Xiao Y, Ning, Shunbin, Gazzar, Mohamed El, Moorman, Jonathan P, Yao, Zhi Q

“…We have previously shown that chronic Hepatitis C virus (HCV) infection can induce DNA damage and immune dysfunctions with excessive oxidative stress in T…”
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