Search Results - "Moorman, David E."

Prefrontal neurons encode context-based response execution and inhibition in reward seeking and extinction by Moorman, David E, Gary Aston-Jones

“…The prefrontal cortex (PFC) regulates multiple aspects of behavior. One hypothesis proposes that PFC segregates different functions into specific subregions:…”
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Phasic locus coeruleus activity regulates cortical encoding of salience information by Vazey, Elena M., Moorman, David E., Aston-Jones, Gary

“…Phasic activation of locus coeruleus (LC)-norepinephrine (NE) neurons is associated with focused attention and behavioral responses to salient stimuli. We used…”
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Motivational activation: a unifying hypothesis of orexin/hypocretin function by Mahler, Stephen V, Moorman, David E, Smith, Rachel J, James, Morgan H, Aston-Jones, Gary

“…Orexins (hypocretins) are involved in a large variety of behaviors and physiological processes including feeding, sleep/wake regulation, and reward. In this…”
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Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats by Moorman, David. E, James, Morgan H, Kilroy, Elisabeth A, Aston-Jones, Gary

“…Abstract The orexin/hypocretin (ORX) system regulates motivation for natural rewards and drugs of abuse such as alcohol. ORX receptor antagonists, most…”
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Orexin/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences by Moorman, David E, Aston-Jones, Gary

“…Recent studies show that glutamate and orexin (ORX, also known as hypocretin) inputs to the ventral tegmental area (VTA) dopamine (DA) cell region are…”
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A Decade of Orexin/Hypocretin and Addiction: Where Are We Now? by James, Morgan H, Mahler, Stephen V, Moorman, David E, Aston-Jones, Gary

“…One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin signaling with drug seeking by showing that activation of these…”
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Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction by Aston-Jones, Gary, Smith, Rachel J, Sartor, Gregory C, Moorman, David E, Massi, Lema, Tahsili-Fahadan, Pouya, Richardson, Kimberlei A

“…Abstract Orexins (synonymous with hypocretins) are recently discovered neuropeptides made exclusively in hypothalamus. Behavioral, anatomical, and…”
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Role of lateral hypothalamic orexin neurons in reward processing and addiction by Aston-Jones, Gary, Smith, Rachel J., Moorman, David E., Richardson, Kimberlei A.

“…Orexins (also known as hypocretins) are recently discovered neuropeptides made exclusively in hypothalamic neurons that have been shown to be important in…”
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The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice by Lopez, Marcelo F, Moorman, David E, Aston-Jones, Gary, Becker, Howard C

“…Abstract The orexin/hypocretin (ORX) system plays a major role in motivation for natural and drug rewards. In particular, a number of studies have shown that…”
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Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol–preferring Sprague–Dawley rats by Moorman, David E, Aston-Jones, Gary

“…Abstract Work from our laboratory has shown that orexin (ORX; or hypocretin) neurons in the lateral hypothalamus are involved in preference for morphine,…”
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Posttraining optogenetic manipulations of basolateral amygdala activity modulate consolidation of inhibitory avoidance memory in rats by Huff, Mary L., Miller, Rachel L., Deisseroth, Karl, Moorman, David E., LaLumiere, Ryan T.

“…Memory consolidation studies, including those examining the role of the basolateral amygdala (BLA), have traditionally used techniques limited in their…”
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Role of orexin/hypocretin in reward-seeking and addiction: Implications for obesity by Cason, Angie M, Smith, Rachel J, Tahsili-Fahadan, Pouya, Moorman, David E, Sartor, Gregory C, Aston-Jones, Gary

“…Abstract Orexins (also named hypocretins) are recently discovered neuropeptides made exclusively in the hypothalamus. Recent studies have shown that orexin…”
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The role of the orbitofrontal cortex in alcohol use, abuse, and dependence by Moorman, David E.

“…One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated behavior. It is no surprise, therefore, that recent work has…”
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Differential Effects of Dorsal and Ventral Medial Prefrontal Cortex Inactivation during Natural Reward Seeking, Extinction, and Cue-Induced Reinstatement by Caballero, Jessica P, Scarpa, Garrett B, Remage-Healey, Luke, Moorman, David E

“…Rodent dorsal medial prefrontal cortex (mPFC), typically prelimbic cortex, is often described as promoting actions such as reward seeking, whereas ventral…”
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A Dynamic Bayesian Model for Characterizing Cross-Neuronal Interactions During Decision-Making by Zhou, Bo, Moorman, David E., Behseta, Sam, Ombao, Hernando, Shahbaba, Babak

“…The goal of this article is to develop a novel statistical model for studying cross-neuronal spike train interactions during decision-making. For an individual…”
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The hypocretin/orexin system as a target for excessive motivation in alcohol use disorders by Moorman, David E.

“…The hypocretin/orexin (ORX) system has been repeatedly demonstrated to regulate motivation for drugs of abuse, including alcohol. In particular, ORX seems to…”
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Prelimbic and infralimbic medial prefrontal cortex neuron activity signals cocaine seeking variables across multiple timescales by Moorman, David E., Aston-Jones, Gary

“…Rationale and Objectives The prefrontal cortex is critical for execution and inhibition of reward seeking. Neural manipulation of rodent medial prefrontal…”
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Differential roles of medial prefrontal subregions in the regulation of drug seeking by Moorman, David E, James, Morgan H, McGlinchey, Ellen M, Aston-Jones, Gary

“…Abstract The prefrontal cortex plays an important role in shaping cognition and behavior. Many studies have shown that medial prefrontal cortex (mPFC) plays a…”
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Selective impact of lateral orbitofrontal cortex inactivation on reinstatement of alcohol seeking in male Long-Evans rats by Arinze, Ifeyinwa, Moorman, David E.

“…The orbitofrontal cortex (OFC) plays a fundamental role in motivated behavior and decision-making. In humans, OFC structure and function is significantly…”
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Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models by Orsini, Caitlin A, Moorman, David E, Young, Jared W, Setlow, Barry, Floresco, Stan B

“…Over the past 20 years there has been a growing interest in the neural underpinnings of cost/benefit decision-making. Recent studies with animal models have…”
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