Search Results - "Moorleghen, Jessica J"

Smooth Muscle Cells Derived From Second Heart Field and Cardiac Neural Crest Reside in Spatially Distinct Domains in the Media of the Ascending Aorta—Brief Report by Sawada, Hisashi, Rateri, Debra L, Moorleghen, Jessica J, Majesky, Mark W, Daugherty, Alan

“…OBJECTIVE—Smooth muscle cells (SMCs) of the proximal thoracic aorta are embryonically derived from the second heart field (SHF) and cardiac neural crest (CNC)…”
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TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions by Chen, Xiaofeng, Rateri, Debra L, Howatt, Deborah A, Balakrishnan, Anju, Moorleghen, Jessica J, Cassis, Lisa A, Daugherty, Alan

“…AngII and TGF-β interact in development of thoracic and abdominal aortic diseases, although there are many facets of this interaction that have not been…”
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Angiotensin I Infusion Reveals Differential Effects of Angiotensin-Converting Enzyme in Aortic Resident Cells on Aneurysm Formation by Sawada, Hisashi, Kukida, Masayoshi, Chen, Xiaofeng, Howatt, Deborah A., Moorleghen, Jessica J., Balakrishnan, Anju, Wu, Congqing, Daugherty, Alan, Lu, Hong S.

“…Background:Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE…”
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Endothelial Cell–Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II–Induced Ascending Aortic Aneurysms in LDL Receptor−/− Mice by Rateri, Debra L, Moorleghen, Jessica J, Balakrishnan, Anju, Owens, A Phillip, Howatt, Deborah A, Subramanian, Venkateswaran, Poduri, Aruna, Charnigo, Richard, Cassis, Lisa A, Daugherty, Alan

“…RATIONALE:Human studies and mouse models have provided evidence for angiotensin II (Ang II)–based mechanisms as an underlying cause of aneurysms localized to…”
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Angiotensin-Converting Enzyme in Smooth Muscle Cells Promotes Atherosclerosis—Brief Report by Chen, Xiaofeng, Howatt, Deborah A, Balakrishnan, Anju, Moorleghen, Jessica J, Wu, Congqing, Cassis, Lisa A, Daugherty, Alan, Lu, Hong

“…OBJECTIVE—Angiotensin-converting enzyme (ACE) is present in many cell types of atherosclerotic lesions. This study determined whether ACE activity in…”
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Calpain Inhibition Attenuates Adipose Tissue Inflammation and Fibrosis in Diet-induced Obese Mice by Muniappan, Latha, Javidan, Aida, Jiang, Weihua, Mohammadmoradi, Shayan, Moorleghen, Jessica J., Katz, Wendy S., Balakrishnan, Anju, Howatt, Deborah A., Subramanian, Venkateswaran

“…Adipose tissue macrophages have been proposed as a link between obesity and insulin resistance. However, the mechanisms underlying these processes are not…”
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Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice by Rateri, Debra L, Moorleghen, Jessica J, Knight, Victoria, Balakrishnan, Anju, Howatt, Deborah A, Cassis, Lisa A, Daugherty, Alan

“…Whole body genetic deletion of AT1a receptors in mice uniformly reduces hypercholesterolemia and angiotensin II-(AngII) induced atherosclerosis and abdominal…”
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Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice by Subramanian, Venkateswaran, Moorleghen, Jessica J, Balakrishnan, Anju, Howatt, Deborah A, Chishti, Athar H, Uchida, Haruhito A

“…Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine…”
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Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions by Sawada, Hisashi, Chen, Jeff Z, Wright, Bradley C, Moorleghen, Jessica J, Lu, Hong S, Daugherty, Alan

“…Contemporary high-resolution ultrasound instruments have sufficient resolution to facilitate the measurement of mouse aortas. These instruments have been…”
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Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice by Xie, Xiaojie, Lu, Hong, Moorleghen, Jessica J, Howatt, Deborah A, Rateri, Debra L, Cassis, Lisa A, Daugherty, Alan

“…There is no proven medical approach to attenuating expansion and rupture of abdominal aortic aneurysms (AAAs). One approach that is currently being…”
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Effects of Endogenous Angiotensin II on Abdominal Aortic Aneurysms and Atherosclerosis in Angiotensin II-Infused Mice by Kukida, Masayoshi, Sawada, Hisashi, Ohno-Urabe, Satoko, Howatt, Deborah A, Moorleghen, Jessica J, Poglitsch, Marko, Daugherty, Alan, Lu, Hong S

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Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms by Poduri, Aruna, Owens, 3rd, A Phillip, Howatt, Deborah A, Moorleghen, Jessica J, Balakrishnan, Anju, Cassis, Lisa A, Daugherty, Alan

“…Angiotensin II (AngII), the main bioactive peptide of the renin angiotensin system, exerts most of its biological actions through stimulation of AngII type 1…”
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Calpain Inhibition Attenuates Angiotensin II–induced Abdominal Aortic Aneurysms and Atherosclerosis in Low-density Lipoprotein Receptor–deficient Mice by Subramanian, Venkateswaran, Uchida, Haruhito A, Ijaz, Talha, Moorleghen, Jessica J, Howatt, Deborah A, Balakrishnan, Anju

“…ABSTRACTChronic infusion of angiotensin II (AngII) augments atherosclerosis and abdominal aortic aneurysm (AAA) formation in hypercholesterolemic mice…”
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Rapid dilation of the abdominal aorta during infusion of angiotensin II detected by noninvasive high-frequency ultrasonography by Barisione, Chiara, Charnigo, Richard, Howatt, Deborah A., Moorleghen, Jessica J., Rateri, Debra L., Daugherty, Alan

“…Infusion of angiotensin II (AngII) via subcutaneous osmotic pumps into mice promotes the development of abdominal aortic aneurysms (AAAs). These AngII-induced…”
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Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice by Kukida, Masayoshi, Amioka, Naofumi, Ye, Dien, Chen, Hui, Moorleghen, Jessica J., Liang, Ching-Ling, Howatt, Deborah A., Katsumata, Yuriko, Yanagita, Motoko, Sawada, Hisashi, Daugherty, Alan, Lu, Hong S.

“…Background and objective Whole body manipulation of the renin-angiotensin system (RAS) consistently exerts profound effects on experimental atherosclerosis…”
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Fludrocortisone Induces Aortic Pathologies in Mice by Ye, Dien, Wu, Congqing, Chen, Hui, Liang, Ching-Ling, Howatt, Deborah A, Franklin, Michael K, Moorleghen, Jessica J, Tyagi, Samuel C, Uijl, Estrellita, Danser, A H Jan, Sawada, Hisashi, Daugherty, Alan, Lu, Hong S

“…In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice…”
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Amlodipine reduces AngII-induced aortic aneurysms and atherosclerosis in hypercholesterolemic mice by Chen, Xiaofeng, Rateri, Debra L, Howatt, Deborah A, Balakrishnan, Anju, Moorleghen, Jessica J, Morris, Andrew J, Charnigo, Richard, Cassis, Lisa A, Daugherty, Alan

“…The purpose of this study was to determine effects of amlodipine, a dihydropyridine calcium channel blocker, on development of angiotensin II (AngII)-induced…”
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LRP1 protects against excessive superior mesenteric artery remodeling by modulating angiotensin II-mediated signaling by Zhang, Jackie M, Au, Dianaly T, Sawada, Hisashi, Franklin, Michael K, Moorleghen, Jessica J, Howatt, Deborah A, Wang, Pengjun, Aicher, Brittany O, Hampton, Brian, Migliorini, Mary, Ni, Fenge, Mullick, Adam E, Wani, Mashhood M, Ucuzian, Areck A, Lu, Hong S, Muratoglu, Selen C, Daugherty, Alan, Strickland, Dudley K

“…Vascular smooth muscle cells (vSMCs) exert a critical role in sensing and maintaining vascular integrity. These cells abundantly express the low-density…”
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3204 Renin-Angiotensin System Inhibitors Do Not Improve Survival in Fibrillin-1 Hypomorphic Mice with Established Aortic Aneurysm by Sheppard, Mary Burchett, Chen, Jeff Zheying, Rateri, Debra L., Moorleghen, Jessica J., Weiland, Mackenzie, Daugherty, Alan

“…OBJECTIVES/SPECIFIC AIMS: Drugs to attenuate aortic growth are usually not initiated in patients with Marfan syndrome until aortic dilation is already present…”
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Prolonged Infusion of Angiotensin II in apoE−/− Mice Promotes Macrophage Recruitment with Continued Expansion of Abdominal Aortic Aneurysm by Rateri, Debra L, Howatt, Deborah A, Moorleghen, Jessica J, Charnigo, Richard, Cassis, Lisa A, Daugherty, Alan

“…Angiotensin II (AngII) infusion initiates abdominal aortic aneurysm (AAA) development due to medial disruption and results in luminal dilation and thrombus…”
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