Search Results - "Moorleghen, Jessica"

Smooth Muscle Cells Derived From Second Heart Field and Cardiac Neural Crest Reside in Spatially Distinct Domains in the Media of the Ascending Aorta—Brief Report by Sawada, Hisashi, Rateri, Debra L, Moorleghen, Jessica J, Majesky, Mark W, Daugherty, Alan

“…OBJECTIVE—Smooth muscle cells (SMCs) of the proximal thoracic aorta are embryonically derived from the second heart field (SHF) and cardiac neural crest (CNC)…”
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TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions by Chen, Xiaofeng, Rateri, Debra L, Howatt, Deborah A, Balakrishnan, Anju, Moorleghen, Jessica J, Cassis, Lisa A, Daugherty, Alan

“…AngII and TGF-β interact in development of thoracic and abdominal aortic diseases, although there are many facets of this interaction that have not been…”
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Prolonged Infusion of Angiotensin II in apoE−/− Mice Promotes Macrophage Recruitment with Continued Expansion of Abdominal Aortic Aneurysm by Rateri, Debra L, Howatt, Deborah A, Moorleghen, Jessica J, Charnigo, Richard, Cassis, Lisa A, Daugherty, Alan

“…Angiotensin II (AngII) infusion initiates abdominal aortic aneurysm (AAA) development due to medial disruption and results in luminal dilation and thrombus…”
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Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile–Induced Thoracic Aortopathy in Mice—Brief Report by Sawada, Hisashi, Ohno-Urabe, Satoko, Ye, Dien, Franklin, Michael K., Moorleghen, Jessica J., Howatt, Deborah A., Mullick, Adam E., Daugherty, Alan, Lu, Hong S.

“…Background: Cross-linking of lysine residues in elastic and collagen fibers is a vital process in aortic development. Inhibition of lysyl oxidase by BAPN…”
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Angiotensin I Infusion Reveals Differential Effects of Angiotensin-Converting Enzyme in Aortic Resident Cells on Aneurysm Formation by Sawada, Hisashi, Kukida, Masayoshi, Chen, Xiaofeng, Howatt, Deborah A., Moorleghen, Jessica J., Balakrishnan, Anju, Wu, Congqing, Daugherty, Alan, Lu, Hong S.

“…Background:Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE…”
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Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice by Rateri, Debra L, Moorleghen, Jessica J, Knight, Victoria, Balakrishnan, Anju, Howatt, Deborah A, Cassis, Lisa A, Daugherty, Alan

“…Whole body genetic deletion of AT1a receptors in mice uniformly reduces hypercholesterolemia and angiotensin II-(AngII) induced atherosclerosis and abdominal…”
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Second Heart Field–Derived Cells Contribute to Angiotensin II–Mediated Ascending Aortopathies by Sawada, Hisashi, Katsumata, Yuriko, Higashi, Hideyuki, Zhang, Chen, Li, Yanming, Morgan, Stephanie, Lee, Lang H., Singh, Sasha A., Chen, Jeff Z., Franklin, Michael K., Moorleghen, Jessica J., Howatt, Deborah A., Rateri, Debra L., Shen, Ying H., LeMaire, Scott A., Aikawa, Masanori, Majesky, Mark W., Lu, Hong S., Daugherty, Alan

“…The ascending aorta is a common location for aneurysm and dissection. This aortic region is populated by a mosaic of medial and adventitial cells that are…”
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β-Aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice by Franklin, Michael K, Sawada, Hisashi, Ito, Sohei, Howatt, Deborah A, Amioka, Naofumi, Liang, Ching-Ling, Zhang, Nancy, Graf, David B, Moorleghen, Jessica J, Katsumata, Yuriko, Lu, Hong S, Daugherty, Alan

“…β-aminopropionitrile (BAPN) is a pharmacological inhibitor of LOX (lysyl oxidase) and LOXLs (LOX-like proteins). Administration of BAPN promotes aortopathies,…”
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Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice by Xie, Xiaojie, Lu, Hong, Moorleghen, Jessica J, Howatt, Deborah A, Rateri, Debra L, Cassis, Lisa A, Daugherty, Alan

“…There is no proven medical approach to attenuating expansion and rupture of abdominal aortic aneurysms (AAAs). One approach that is currently being…”
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Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice by Subramanian, Venkateswaran, Moorleghen, Jessica J, Balakrishnan, Anju, Howatt, Deborah A, Chishti, Athar H, Uchida, Haruhito A

“…Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine…”
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Deletion of AT1a (Angiotensin II Type 1a) Receptor or Inhibition of Angiotensinogen Synthesis Attenuates Thoracic Aortopathies in Fibrillin1C1041G/+ Mice by Chen, Jeff Z., Sawada, Hisashi, Ye, Dien, Katsumata, Yuriko, Kukida, Masayoshi, Ohno-Urabe, Satoko, Moorleghen, Jessica J., Franklin, Michael K., Howatt, Deborah A., Sheppard, Mary B., Mullick, Adam E., Lu, Hong S., Daugherty, Alan

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Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice by Muniappan, Latha, Okuyama, Michihiro, Javidan, Aida, Thiagarajan, Devi, Jiang, Weihua, Moorleghen, Jessica J., Yang, Lihua, Balakrishnan, Anju, Howatt, Deborah A., Uchida, Haruhito A., Saido, Takaomi C., Subramanian, Venkateswaran

“…[Figure: see text]…”
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Functional Exploration of Conserved Sequences in the Distal Face of Angiotensinogen—Brief Report by Amioka, Naofumi, Wu, Chia-Hua, Sawada, Hisashi, Ito, Sohei, Pettey, Alex C., Wu, Congqing, Moorleghen, Jessica J., Howatt, Deborah A., Graf, Gregory A., Vander Kooi, Craig W., Daugherty, Alan, Lu, Hong S.

“…Angiotensinogen (AGT) is an essential component in the renin-angiotensin system. AGT has highly conserved sequences in the loop and β-sheet regions among…”
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miR-146a Deficiency Accelerates Hepatic Inflammation Without Influencing Diet-induced Obesity in Mice by Javidan, Aida, Jiang, Weihua, Okuyama, Michihiro, Thiagarajan, Devi, Yang, Lihua, Moorleghen, Jessica J., Muniappan, Latha, Subramanian, Venkateswaran

“…miR-146a, an anti-inflammatory microRNA, is shown to be a negative regulator of adipocyte inflammation. However, the functional contribution of miR-146a in the…”
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Endothelial Cell–Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II–Induced Ascending Aortic Aneurysms in LDL Receptor−/− Mice by Rateri, Debra L, Moorleghen, Jessica J, Balakrishnan, Anju, Owens, A Phillip, Howatt, Deborah A, Subramanian, Venkateswaran, Poduri, Aruna, Charnigo, Richard, Cassis, Lisa A, Daugherty, Alan

“…RATIONALE:Human studies and mouse models have provided evidence for angiotensin II (Ang II)–based mechanisms as an underlying cause of aneurysms localized to…”
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Angiotensinogen Exerts Effects Independent of Angiotensin II by Lu, Hong, Wu, Congqing, Howatt, Deborah A, Balakrishnan, Anju, Moorleghen, Jessica J, Chen, Xiaofeng, Zhao, Mingming, Graham, Mark J, Mullick, Adam E, Crooke, Rosanne M, Feldman, David L, Cassis, Lisa A, Vander Kooi, Craig W, Daugherty, Alan

“…OBJECTIVE—This study determined whether angiotensinogen (AGT) has angiotensin II–independent effects using multiple genetic and pharmacological manipulations…”
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Angiotensin II Induces Region-Specific Medial Disruption during Evolution of Ascending Aortic Aneurysms by Rateri, Debra L, Davis, Frank M, Balakrishnan, Anju, Howatt, Deborah A, Moorleghen, Jessica J, O’Connor, William N, Charnigo, Richard, Cassis, Lisa A, Daugherty, Alan

“…Angiotensin II (Ang II) promotes development of ascending aortic aneurysms (AAs), but progression of this pathology is undefined. We evaluated factors…”
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Two Amino Acids Proximate to the Renin Cleavage Site of Human Angiotensinogen Do Not Affect Blood Pressure and Atherosclerosis in Mice—Brief Report by Wu, Chia-Hua, Wu, Congqing, Howatt, Deborah A., Moorleghen, Jessica J., Cassis, Lisa A., Daugherty, Alan, Lu, Hong S.

“…OBJECTIVE:Renin cleavage of angiotensinogen has species specificity. As the residues at positions 11 and 12 are different between human angiotensinogen and…”
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Ultrasound Monitoring of Descending Aortic Aneurysms and Dissections in Mice by Sawada, Hisashi, Franklin, Michael K., Moorleghen, Jessica J., Howatt, Deborah A., Kukida, Masayoshi, Lu, Hong S., Daugherty, Alan

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Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms by Poduri, Aruna, Owens, 3rd, A Phillip, Howatt, Deborah A, Moorleghen, Jessica J, Balakrishnan, Anju, Cassis, Lisa A, Daugherty, Alan

“…Angiotensin II (AngII), the main bioactive peptide of the renin angiotensin system, exerts most of its biological actions through stimulation of AngII type 1…”
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