Search Results - "Moore, Xiao Lei"

Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy by Fang, Lu, Ellims, Andris H, Moore, Xiao-lei, White, David A, Taylor, Andrew J, Chin-Dusting, Jaye, Dart, Anthony M

“…Circulating microRNAs may represent novel markers for cardiovascular diseases. We evaluated whether circulating miRNAs served as potential biomarkers for…”
Get full text

High‐density lipoprotein inhibits human M1 macrophage polarization through redistribution of caveolin‐1 by Lee, Man K S, Moore, Xiao‐Lei, Fu, Yi, Al‐Sharea, Annas, Dragoljevic, Dragana, Fernandez‐Rojo, Manuel A, Parton, Robert, Sviridov, Dmitri, Murphy, Andrew J, Chin‐Dusting, Jaye P F

“…Background and Purpose Monocyte‐derived macrophages are critical in the development of atherosclerosis and can adopt a wide range of functional phenotypes…”
Get full text

Systemic inflammatory response following acute myocardial infarction by Fang, Lu, Moore, Xiao-Lei, Dart, Anthony M, Wang, Le-Min

“…Acute cardiomyocyte necrosis in the infarcted heart generates damage-associated molecular patterns, activating complement and toll-like receptor/interleukin-1…”
Get full text

Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction by Fang, Lu, Gao, Xiao-Ming, Moore, Xiao-Lei, Kiriazis, Helen, Su, Yidan, Ming, Ziqiu, Lim, Yean Leng, Dart, Anthony M, Du, Xiao-Jun

“…Abstract Cardiac rupture remains a fatal complication of acute myocardial infarction (MI) with its mechanism partially understood. We hypothesized that damage…”
Get full text

Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis by Gao, Xiao-Ming, Wong, Geoffrey, Wang, Binghui, Kiriazis, Helen, Moore, Xiao-Lei, Su, Yi-Dan, Dart, Anthony, Du, Xiao-Jun

“…BACKGROUND AND OBJECTIVEInhibition of established left ventricular hypertrophy (LVH) and fibrosis may bring clinical benefits by reducing cardiac morbidity and…”
Get full text

Down-regulation of mitofusin-2 expression in cardiac hypertrophy in vitro and in vivo by Fang, Lu, Moore, Xiao-Lei, Gao, Xiao-Ming, Dart, Anthony M., Lim, Yean Leng, Du, Xiao-Jun

“…Mitofusin-2 (Mfn2) suppresses smooth muscle cell proliferation through inhibition of the Ras-extracellular signal-regulated kinases (ERK1/2) pathway. Since the…”
Get full text

Comparison of inflammation, arterial stiffness and traditional cardiovascular risk factors between rheumatoid arthritis and inflammatory bowel disease by Fan, Fenling, Galvin, Abby, Fang, Lu, White, David Andrew, Moore, Xiao-Lei, Sparrow, Miles, Cicuttini, Flavia, Dart, Anthony Michael

“…Inflammation plays an important role in the pathogenesis of atherosclerosis. The link between rheumatoid arthritis (RA) and an increased risk of cardiovascular…”
Get full text

Plasma Macrophage Migration Inhibitor Factor Is Elevated in Response to Myocardial Ischemia by Fan, Fenling, Fang, Lu, Moore, Xiao‐Lei, Xie, Xuegang, Du, Xiao‐Jun, White, David A., O'Brien, Jessica, Thomson, Helen, Wang, Jun, Schneider, Hans G., Ellims, Andris, Barber, Thomas W., Dart, Anthony M.

“…Background Macrophage migration inhibitory factor (MIF) is a key regulator of inflammatory responses, including in the heart. Plasma MIF is elevated early in…”
Get full text

Relaxin Antagonizes Hypertrophy and Apoptosis in Neonatal Rat Cardiomyocytes by Moore, Xiao-lei, Tan, Su-ling, Lo, Chen-yi, Fang, Lu, Su, Yi-Dan, Gao, Xiao-Ming, Woodcock, Elizabeth A, Summers, Roger J, Tregear, Geoffrey W, Bathgate, Ross A. D, Du, Xiao-Jun

“…The pregnancy hormone relaxin has recently been shown to be cardio-protective. Despite its well-established antifibrotic actions in the heart, the effects of…”
Get full text

Associations between fibrocytes and postcontrast myocardial T1 times in hypertrophic cardiomyopathy by Fang, Lu, Beale, Anna, Ellims, Andris H, Moore, Xiao-Lei, Ling, Liang-Han, Taylor, Andrew J, Chin-Dusting, Jaye, Dart, Anthony M

“…Fibrocytes are bone marrow-derived mesenchymal progenitors that have been linked to various fibrotic disorders. This study was undertaken to investigate…”
Get full text

Relaxin Activates Multiple cAMP Signaling Pathway Profiles in Different Target Cells by Halls, Michelle L., Hewitson, Tim D., Moore, Xiao-Lei, Du, Xiao-Jun, Bathgate, Ross A. D., Summers, Roger J.

“…Although RXFP1‐cAMP signaling in HEK293T cell systems is now relatively well‐defined, the signaling pathways activated by relaxin in its target cells and…”
Get full text

Reversal of Cardiac Fibrosis and Related Dysfunction by Relaxin: Experimental Findings by Du, Xiao‐Jun, Xu, Qi, Lekgabe, Edna, Gao, Xiao‐Ming, Kiriazis, Helen, Moore, Xiao‐Lei, Dart, Anthony M., Tregear, Geoffrey W., Bathgate, Ross A. D., Samuel, Chrishan S.

“…As a hallmark of heart disease, cardiac fibrosis contributes to the development of heart failure and arrhythmias and forms a key therapeutic target. There is a…”
Get full text

α1-Adrenergic Activation Upregulates Expression of Relaxin Receptor RXFP1 in Cardiomyocytes by Moore, Xiao-Lei, Hong, Alice, Du, Xiao-Jun

“…Cardiac RXFP1 was upregulated upon activation of the α1‐adrenergic receptor (AR) through signal pathways involving protein kinase A and C and ERK. In contrast,…”
Get full text

The Effects of Relaxin and Estrogen Deficiency on Collagen Deposition and Hypertrophy of Nonreproductive Organs by Lekgabe, Edna D, Royce, Simon G, Hewitson, Tim D, Tang, Mimi L. K, Zhao, Chongxin, Moore, Xiao Lei, Tregear, Geoffrey W, Bathgate, Ross A. D, Du, Xiao-Jun, Samuel, Chrishan S

“…In this study, we determined the effects of relaxin and estrogen deficiency and estrogen replacement therapy (ERT) on the cardiac, renal, and pulmonary…”
Get full text

Native LDL promotes differentiation of human monocytes to macrophages with an inflammatory phenotype by Al-Sharea, Annas, Lee, Man Kit Sam, Moore, Xiao-Lei, Fang, Lu, Sviridov, Dmitri, Chin-Dusting, Jaye, Andrews, Karen L, Murphy, Andrew J

“…Recruitment of monocytes in atherosclerosis is dependent upon increased levels of plasma lipoproteins which accumulate in the blood vessel wall. The…”
Get more information

Caveolin-1 Plays a Critical Role in the Differentiation of Monocytes into Macrophages by Fu, Yi, Moore, Xiao-Lei, Lee, Man K S, Fernández-Rojo, Manuel A, Parat, Marie-Odile, Parton, Robert G, Meikle, Peter J, Sviridov, Dmitri, Chin-Dusting, Jaye P F

“…OBJECTIVE—Monocyte to macrophage differentiation is an essential step in atherogenesis. The structure protein of caveolae, caveolin-1, is increased in primary…”
Get full text

Effects of high‐ and low‐dose aspirin on adaptive immunity and hypertension in the stroke‐prone spontaneously hypertensive rat by Khan, Shanzana I., Shihata, Waled A., Andrews, Karen L., Lee, Man K. S., Moore, Xiao-Lei, Jefferis, Ann-Maree, Vinh, Antony, Gaspari, Tracey, Dragoljevic, Dragana, Jennings, Garry L., Murphy, Andrew J., Chin-Dusting, Jaye P. F.

“…ABSTRACT Despite its well‐known antithrombotic properties, the effect of aspirin on blood pressure (BP) and hypertension pathology is unclear. The hugely…”
Get full text

Splenic release of platelets contributes to increased circulating platelet size and inflammation after myocardial infarction by Gao, Xiao-Ming, Moore, Xiao-Lei, Liu, Yang, Wang, Xin-Yu, Han, Li-Ping, Su, Yidan, Tsai, Alan, Xu, Qi, Zhang, Ming, Lambert, Gavin W, Kiriazis, Helen, Gao, Wei, Dart, Anthony M, Du, Xiao-Jun

“…Acute myocardial infarction (AMI) is characterized by a rapid increase in circulating platelet size but the mechanism for this is unclear. Large platelets are…”
Get more information

Relaxin Reverses Cardiac and Renal Fibrosis in Spontaneously Hypertensive Rats by Lekgabe, Edna D, Kiriazis, Helen, Zhao, Chongxin, Xu, Qi, Moore, Xiao Lei, Su, Yidan, Bathgate, Ross A.D, Du, Xiao-Jun, Samuel, Chrishan S

“…The antifibrotic effects of the peptide hormone relaxin on cardiac and renal fibrosis were studied in 9- to 10-month-old male spontaneously hypertensive rats…”
Get full text

Decreased fibrocyte number is associated with atherosclerotic plaque instability in man by LU FANG, MOORE, Xiao-Lei, CHAN, William, WHITE, David A, CHIN-DUSTING, Jaye, DART, Anthony M

“…Plaque rupture partly results from inadequate collagen synthesis due to lower smooth muscle cell numbers in fibrous caps. Fibrocytes are bone-marrow-derived…”
Get full text