Search Results - "Moore, Stephen P"

Catalytic Asymmetric Synthesis of Piperidines from Pyrrolidine: Concise Synthesis of L-733,060 by Bilke, Julia L, Moore, Stephen P, O’Brien, Peter, Gilday, John

“…Catalytic asymmetric deprotonation-aldehyde trapping-ring expansion from a 5- to a 6-ring delivers a concise route to each stereoisomer of β-hydroxy…”
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YAP facilitates melanoma migration through regulation of actin‐related protein 2/3 complex subunit 5 (ARPC5) by Lui, Jason W., Moore, Stephen P.G., Huang, Lee, Ogomori, Kelsey, Li, Yan, Lang, Deborah

“…Yes‐associated protein 1 (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) are transcriptional coactivators that have been implicated in…”
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Targeting Pan-ETS Factors Inhibits Melanoma Progression by Huang, Lee, Zhai, Yougang, La, Jennifer, Lui, Jason W, Moore, Stephen P G, Little, Elizabeth C, Xiao, Sixia, Haresi, Adil J, Brem, Candice, Bhawan, Jag, Lang, Deborah

“…The failure of once promising target-specific therapeutic strategies often arises from redundancies in gene expression pathways. Even with new melanoma…”
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Transcription Factors and DNA Repair Enzymes Compete for Damaged Promoter Sites by Moore, Stephen P.G., Kruchten, Joshua, Toomire, Kimberly J., Strauss, Phyllis R.

“…Transcriptional regulation is a tightly regulated, vital process. The transcription factor cyclic AMP-response element-binding protein 1 (CREB1) controls ∼25%…”
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DNA modifications repaired by base excision repair are epigenetic by Moore, Stephen P.G., Toomire, Kimberly J., Strauss, Phyllis R.

“…•Oxidative DNA damage and uracil are repaired by base excision repair (BER).•CREB regulates ∼25% of the eukaryotic transcriptome.•Damage repaired by BER…”
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Organolithium-Mediated Conversion of β-Alkoxy Aziridines into Allylic Sulfonamides: Effect of the N-Sulfonyl Group and a Formal Synthesis of (±)-Perhydrohistrionicotoxin by Coote, Susannah C, Moore, Stephen P, O’Brien, Peter, Whitwood, Adrian C, Gilday, John

“…In 18 out of 20 examples of the organolithium-mediated conversion of β-alkoxy aziridines into substituted allylic sulfonamides, use of a Bus (Bus = t-BuSO2)…”
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New Route to Azaspirocycles via the Organolithium-Mediated Conversion of β-Alkoxy Aziridines into Cyclopentenyl Amines by Moore, Stephen P, Coote, Susannah C, O'Brien, Peter, Gilday, John

“…A new three-step route to azaspirocycles involving the organolithium-mediated conversion of β-alkoxy aziridines into substituted cyclopentenyl amines,…”
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Recurrent hypoglycemia increases hypothalamic glucose phosphorylation activity in rats by Osundiji, Mayowa A, Hurst, Paul, Moore, Stephen P, Markkula, S. Pauliina, Yueh, Chen Y, Swamy, Ashwini, Hoashi, Shu, Shaw, Jill S, Riches, Christine H, Heisler, Lora K, Evans, Mark L

“…Abstract The mechanisms underpinning impaired defensive counterregulatory responses to hypoglycemia that develop in some people with diabetes who suffer…”
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Lithiation-electrophilic trapping of N-sulfonyl-activated ethylene aziridines by Huang, Jianhui, Moore, Stephen P, O'Brien, Peter, Whitwood, Adrian C, Gilday, John

“…A detailed study on the lithiation-electrophilic trapping of N-sulfonyl ethylene aziridines is described. The optimum results required use of a…”
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Brain Glucosamine Boosts Protective Glucoprivic Feeding by Osundiji, Mayowa A, Zhou, Ligang, Shaw, Jill, Moore, Stephen P, Yueh, Chen-Yu, Sherwin, Robert, Heisler, Lora K, Evans, Mark L

“…The risk of iatrogenic hypoglycemia is increased in diabetic patients who lose defensive glucoregulatory responses, including the important warning symptom of…”
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Nutritional state influences Nociceptin/Orphanin FQ peptide receptor expression in the dorsal raphe nucleus by Przydzial, Magdalena J., Garfield, Alastair S., Lam, Daniel D., Moore, Stephen P., Evans, Mark L., Heisler, Lora K.

“…Agonists of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor stimulate food intake. Concordantly, neuroanatomical localization of NOP receptor mRNA…”
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Asymmetric synthesis via aziridinium ions: exploring the stereospecificity of the ring opening of aziridinium ions and a formal synthesis of (−)-swainsonine by Oxenford, Sally J., Moore, Stephen P., Carbone, Giorgio, Barker, Graeme, O’Brien, Peter, Shipton, Mark R., Gilday, John, Campos, Kevin R.

“…The use of aziridinium ions in two different projects is described. First, the stereospecificity of the ring opening of aziridinium ions with MeNH 2 as a route…”
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Brief ischemia-reperfusion induces stunning of endothelium in canine coronary artery by KIM, Y. D, FOMSGAARD, J. S, MYERS, A. K, HEIM, K. F, RAMWELL, P. W, THOMAS, G, KAGAN, E, MOORE, S. P, COUGHLIN, S. S, KUWAHARA, M, ANALOUEI, A

“…Brief ischemic episodes that induce stunning of the myocardium may also induce stunning of the coronary endothelium. To test this hypothesis, we examined both…”
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Peripheral calcifying odontogenic cyst (Gorlin cyst) by Swan, R H, Houston, G D, Moore, S P

“…A case report of a rare peripheral calcifying odontogenic cyst is presented. The clinical, radiographic and histopathologic features of the lesion are…”
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