Search Results - "Moore, Stephen J"

Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index by Desnoyers, Luc R, Vasiljeva, Olga, Richardson, Jennifer H, Yang, Annie, Menendez, Elizabeth E M, Liang, Tony W, Wong, Chihunt, Bessette, Paul H, Kamath, Kathy, Moore, Stephen J, Sagert, Jason G, Hostetter, Daniel R, Han, Fei, Gee, Jason, Flandez, Jeanne, Markham, Kate, Nguyen, Margaret, Krimm, Michael, Wong, Kenneth R, Liu, Shouchun, Daugherty, Patrick S, West, James W, Lowman, Henry B

“…Target-mediated toxicity constitutes a major limitation for the development of therapeutic antibodies. To redirect the activity of antibodies recognizing…”
Get more information

Anion-Anion Proton Transfer in Hydrogen Bonded Complexes by Gale, Philip A., Hiscock, Jennifer R., Moore, Stephen J., Caltagirone, Claudia, Hursthouse, Michael B., Light, Mark E.

“…Complexation of dihydrogen phosphate by an anion receptor containing six hydrogen bond donor groups has been shown to reduce the pKa of the bound anionic…”
Get full text

Impact of HLA Polymorphism on the Immune Response to Bacillus Anthracis Protective Antigen in Vaccination versus Natural Infection by Ascough, Stephanie, Ingram, Rebecca J, Chu, Karen K. Y, Moore, Stephen J, Gallagher, Theresa, Dyson, Hugh, Doganay, Mehmet, Metan, Gökhan, Ozkul, Yusuf, Baillie, Les, Williamson, E. Diane, Robinson, John H, Maillere, Bernard, Boyton, Rosemary J, Altmann, Daniel M

“…The causative agent of anthrax, Bacillus anthracis, evades the host immune response and establishes infection through the production of binary exotoxins…”
Get full text

Anthrax lethal factor as an immune target in humans and transgenic mice and the impact of HLA polymorphism on CD4+ T cell immunity by Ascough, Stephanie, Ingram, Rebecca J, Chu, Karen K, Reynolds, Catherine J, Musson, Julie A, Doganay, Mehmet, Metan, Gökhan, Ozkul, Yusuf, Baillie, Les, Sriskandan, Shiranee, Moore, Stephen J, Gallagher, Theresa B, Dyson, Hugh, Williamson, E Diane, Robinson, John H, Maillere, Bernard, Boyton, Rosemary J, Altmann, Daniel M

“…Bacillus anthracis produces a binary toxin composed of protective antigen (PA) and one of two subunits, lethal factor (LF) or edema factor (EF). Most studies…”
Get full text

Screening of peptide libraries against protective antigen of Bacillus anthracis in a disposable microfluidic cartridge by Kogot, Joshua M, Zhang, Yanting, Moore, Stephen J, Pagano, Paul, Stratis-Cullum, Dimitra N, Chang-Yen, David, Turewicz, Marek, Pellegrino, Paul M, de Fusco, Andre, Soh, H Tom, Stagliano, Nancy E

“…Bacterial surface peptide display has gained popularity as a method of affinity reagent generation for a wide variety of applications ranging from drug…”
Get full text

A four year longitudinal sero-epidemiological study of bovine herpesvirus type-1 (BHV-1) in adult cattle in 107 unvaccinated herds in south west England by Woodbine, Kerry A, Medley, Graham F, Moore, Stephen J, Ramirez-Villaescusa, Ana M, Mason, Sam, Green, Laura E

“…Bovine herpesvirus type-1 (BHV-1) is an important pathogen of cattle that presents with a variety of clinical signs, including the upper respiratory tract…”
Get full text

A Probody T Cell-Engaging Bispecific Antibody Targeting EGFR and CD3 Inhibits Colon Cancer Growth with Limited Toxicity by Boustany, Leila M, LaPorte, Sherry L, Wong, Laurie, White, Clayton, Vinod, Veena, Shen, Joel, Yu, Wendy, Koditek, David, Winter, Michael B, Moore, Stephen J, Mei, Li, Diep, Linnea, Huang, Yuanhui, Liu, Shouchun, Vasiljeva, Olga, West, Jim, Richardson, Jennifer, Irving, Bryan, Belvin, Marcia, Kavanaugh, W Michael

“…T cell-engaging bispecific antibodies (TCB) are highly potent therapeutics that can recruit and activate cytotoxic T cells to stimulate an antitumor immune…”
Get full text

Aggregating sustainability indicators: Beyond the weighted sum by Rowley, Hazel V., Peters, Gregory M., Lundie, Sven, Moore, Stephen J.

“…Sustainability analysts and environmental decision makers often overcome the difficulty of interpreting comprehensive environmental profiles by aggregating the…”
Get full text

Nonclinical Efficacy and Safety of CX-2029, an Anti-CD71 Probody-Drug Conjugate by Singh, Shweta, Serwer, Laura, DuPage, Amy, Elkins, Kristi, Chauhan, Niharika, Ravn, Matthew, Buchanan, Fritz, Wang, Leyu, Krimm, Michael, Wong, Ken, Sagert, Jason, Tipton, Kimberly, Moore, Stephen J, Huang, Yuanhui, Jang, Andrew, Ureno, Eric, Miller, Adam, Patrick, Sarah, Duvur, Shanti, Liu, Shouchun, Vasiljeva, Olga, Li, Yingchun, Henriques, Tracy, Badagnani, Ilaria, Jeffries, Shawn, Schleyer, Siew, Leanna, Rob, Krebber, Claus, Viswanathan, Sridhar, Desnoyers, Luc, Terrett, Jonathan, Belvin, Marcia, Morgan-Lappe, Susan, Kavanaugh, W Michael, Richardson, Jennifer

“…Probody therapeutics (Pb-Txs) are conditionally activated antibody-drug conjugates (ADCs) designed to remain inactive until proteolytically activated in the…”
Get full text

Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport by Spooner, Michael J, Li, Hongyu, Marques, Igor, Costa, Pedro M R, Wu, Xin, Howe, Ethan N W, Busschaert, Nathalie, Moore, Stephen J, Light, Mark E, Sheppard, David N, Félix, Vítor, Gale, Philip A

“…A series of fluorinated tripodal tris-thioureas function as highly active anion transporters across lipid bilayers and cell membranes. Here, we investigate…”
Get full text

Tripodal transmembrane transporters for bicarbonate by Busschaert, Nathalie, Gale, Philip A, Haynes, Cally J E, Light, Mark E, Moore, Stephen J, Tong, Christine C, Davis, Jeffery T, Harrell, Jr, William A

“…Easy-to-make tripodal tris-thiourea receptors based upon tris(2-aminoethyl)amine are capable of chloride/bicarbonate transport and as such represent a new…”
Get more information

Highly effective yet simple transmembrane anion transporters based upon ortho-phenylenediamine bis-ureas by Karagiannidis, Louise E, Haynes, Cally J E, Holder, Katie J, Kirby, Isabelle L, Moore, Stephen J, Wells, Neil J, Gale, Philip A

“…Simple, highly fluorinated receptors are shown to function as highly effective transmembrane anion antiporters with the most active transporters rivalling the…”
Get more information

A four year longitudinal sero-epidemiology study of Neospora caninum in adult cattle from 114 cattle herds in south west England: associations with age, herd and dam-offspring pairs by Woodbine, Kerry A, Medley, Graham F, Moore, Stephen J, Ramirez-Villaescusa, Ana, Mason, Sam, Green, Laura E

“…Neosporosis caused by the protozoan parasite Neospora caninum, is an economically important cause of abortion, stillbirth, low milk yield, reduced weight gain…”
Get full text

A dual host approach to transmembrane transport of salts by Moore, Stephen J, Fisher, Matthew G, Yano, Masafumi, Tong, Christine C, Gale, Philip A

“…A dual host approach for M(+)/Cl(-) co-transport has been shown to be effective in lipid bilayers consisting of POPC using fluorescence-based transport assays…”
Get more information

A synergistic approach to anion antiport by Moore, Stephen J, Fisher, Matthew G, Yano, Masafumi, Tong, Christine C, Gale, Philip A

“…A synergistic approach to Cl(-)/HCO(3)(-) antiport has been demonstrated in POPC lipid bilayers using an ion selective electrode assay showing that, when using…”
Get more information

Seroprevalence and epidemiological characteristics of Mycobacterium avium subsp. paratuberculosis on 114 cattle farms in south west England by Woodbine, Kerry A., Schukken, Ynte H., Green, Laura E., Ramirez-Villaescusa, Ana, Mason, Sam, Moore, Stephen J., Bilbao, Christine, Swann, Natalie, Medley, Graham F.

“…Between December 2002 and April 2006, 114 cattle farms in the south west of England were visited at least once, with 100 farms visited three times. A total of…”
Get full text

CD4+ T Cells Targeting Dominant and Cryptic Epitopes from Bacillus anthracis Lethal Factor by Ascough, Stephanie, Ingram, Rebecca J, Chu, Karen K Y, Musson, Julie A, Moore, Stephen J, Gallagher, Theresa, Baillie, Les, Williamson, Ethel D, Robinson, John H, Maillere, Bernard, Boyton, Rosemary J, Altmann, Daniel M

“…Anthrax is an endemic infection in many countries, particularly in the developing world. The causative agent, Bacillus anthracis, mediates disease through the…”
Get full text

A dual host approach to NiSO4 extraction by Bates, Gareth W., Davidson, James E., Forgan, Ross S., Gale, Philip A., Henderson, David K., King, Michael G., Light, Mark E., Moore, Stephen J., Tasker, Peter A., Tong, Christine C.

“…This paper reports the synthesis of sulphate extractants, N,N′-bis-(2-dibutylamino-ethyl)-isophthalamide (1), pyridine-2,6-dicarboxylic acid…”
Get full text

A substance flow analysis in the southern hemisphere: cadmium in the Australian economy by Kwonpongsagoon, Suphaphat, Waite, David T., Moore, Stephen J., Brunner, Paul H.

“…This article analyses the flow of cadmium through the Australian economy during the one-year period, 1998-1999 using material flow analysis (MFA) or substance…”
Get full text

Trial in Progress: A Phase 1b Study of ELA026 in Patients with Secondary Hemophagocytic Lymphohistiocytosis by Leach, Timothy S., Lane, Hayley, Kim, Benjamin, Moore, Stephen J., Panicker, Sandip, Patou, Gary

Get full text