Search Results - "Moore, P.K."

Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air? by Li, L, Moore, P.K

“…The past two decades have seen an upsurge in interest in the biology of naturally occurring gases, starting with nitric oxide and extending through to carbon…”
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Hydrogen sulphide in the hypothalamus causes an ATP-sensitive K+ channel-dependent decrease in blood pressure in freely moving rats by Dawe, G.S, Han, S.P, Bian, J.-S, Moore, P.K

“…Abstract Hydrogen sulfide (H2 S) is a naturally occurring gas that may act as an endogenous signaling molecule. In the brain, H2 S is mainly produced by…”
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A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain by Lee, A.T.-H, Jitendrakumar Shah, J, Li, L, Cheng, Y, Moore, P.K, Khanna, S

“…Abstract The present study investigated the hypothesis that hydrogen sulfide (H2 S) is pro-nociceptive in the formalin model of persistent inflammatory pain in…”
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Human Chimeric Superoxide 2,3 Prevents Renal Ischemia/Reperfusion Injury by Moore, P.K, Gewehr, E.V, Moore, E.E, Koul, H, Kim, F.J

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Low Dose Blood Transfusion Promotes Pancreatic Cancer Metastases by Benson, D.D, Silliman, C.C, Moore, E.E, Moore, P.K, Kelher, M.R, Barnett, C.C

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Sex-Specific Hormone Concentration In Transfused Stored Erythrocytes by Benson, D.D, Silliman, C.C, Kelher, M.R, Bensard, D.D, Moore, P.K, Barnett, C.C

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Characterization of the novel nitric oxide synthase inhibitor 7‐nitro indazole and related indazoles: antinociceptive and cardiovascular effects by Moore, P.K., Wallace, P., Gaffen, Z., Hart, S.L., Babbedge, R.C.

“…1 7‐Nitro indazole (7‐NI, 10–50 mg kg−1), 6‐nitro indazole and indazole (25–100 mg kg−1) administered i.p. in the mouse produce dose‐related antinociception in…”
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The Plasma Fraction of Stored Erythrocytes Augments Pancreas Cancer Metastases in Male versus Female Mice by Moore, P.K, Benson, D, Kelher, M, Moore, E.E, Silliman, C.C, Barnett, C.C

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7‐Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti‐nociceptive activity in the mouse without increasing blood pressure by Moore, P.K., Babbedge, R.C., Wallace, P., Gaffen, Z.A., Hart, S.L.

“…7‐Nitro indazole (7‐NI) inhibits mouse cerebellar nitric oxide synthase (NOS) in vitro with an IC50 of 0.47 μm. Following i.p. administration in mice, 7‐NI…”
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Inhibition of rat cerebellar nitric oxide synthase by 7‐nitro indazole and related substituted indazoles by Babbedge, R.C., Bland‐Ward, P.A., Hart, S.L., Moore, P.K.

“…1 7‐Nitro indazole (7‐NI) produces potent inhibition of rat cerebellar nitric oxide synthase (NOS) with an IC50 of 0.9 ± 0.1 μm (n = 6). NOS activity is…”
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l‐NG‐nitro arginine methyl ester exhibits antinociceptive activity in the mouse by Moore, P.K., Oluyomi, A.O., Babbedge, R.C., Wallace, P., Hart, S.L.

“…1 l‐NG‐nitro arginine methyl ester (l‐NAME, 1–75 mg kg−1) administered intraperitoneally (i.p.) elicits dose‐related antinociception in the mouse assessed by…”
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Inhibition of nitric oxide synthase by 1‐(2‐trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects by Handy, Rachel L.C., Harb, H.L., Wallace, P., Gaffen, Z., Whitehead, K.J., Moore, P.K.

“…1 The ability of a range of substituted imidazole compounds to inhibit mouse cerebellar neuronal nitric oxide synthase (nNOS), bovine aortic endothelial NOS…”
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An overview of the biological significance of endogenous gases: new roles for old molecules by Li, L, Moore, P K

“…Biologically active gases that occur naturally in the body include nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H(2)S). Each of these…”
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Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents by Rose, Peter, Whiteman, Matt, Moore, Philip K, Zhu, Yi Zhun

“…S-Alk(en)yl cysteine sulfoxides are odourless, non-protein sulfur amino acids typically found in members of the family Alliaceae and are the precursors to the…”
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The effect of arginine and nitric oxide on resistance blood vessels of the perfused rat kidney by Bhardwaj, R., Moore, P.K.

“…1 The vasodilator effects of arginine, nitric oxide (NO), acetylcholine (ACh) and sodium nitroprusside (NP) in the noradrenaline‐preconstricted (‘high tone’)…”
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Selective inhibitors of neuronal nitric oxide synthase – is no NOS really good NOS for the nervous system? by Moore, P.K., Handy, R.L.C.

“…It is now ten years since NO was shown to account for the biological activity of endothelium-derived relaxing factor (EDRF). It is also the tenth anniversary…”
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Synergism between hydrogen sulfide (H 2S) and nitric oxide (NO) in vasorelaxation induced by stonustoxin (SNTX), a lethal and hypotensive protein factor isolated from stonefish Synanceja horrida venom by Liew, H.C., Khoo, H.E., Moore, P.K., Bhatia, M., Lu, J., Moochhala, S.M.

“…Stonustoxin (SNTX) is a 148 kDa, dimeric, hypotensive and lethal protein factor isolated from the venom of the stonefish Synanceja horrida. SNTX (10–320 ng/ml)…”
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Cardioprotective effects of nitroparacetamol and paracetamol in myocardial infarction by Chong, C.L., Zhu, Y.Z., Moore, P.K.

“…Study objectives: The biology of nitric oxide has been extensively studied for many years. Currently, researchers are investigating the possibility that…”
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Synergistic anti‐nociceptive effect of l‐NG‐nitro arginine methyl ester (l‐NAME) and flurbiprofen in the mouse by Morgan, C.V.J., Babbedge, R.C., Gaffen, Z., Wallace, P., Hart, S.L., Moore, P.K.

“…1 l‐NG‐nitro arginine methyl ester (l‐NAME) administered i.p. produces anti‐nociception in the mouse assessed by the formalin‐induced paw licking and acetic…”
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l‐NG‐monomethyl arginine and l‐NG‐nitro arginine inhibit non‐adrenergic, non‐cholinergic relaxation of the mouse anococcygeus muscle by Gibson, A., Mirzazadeh, Shokoufeh, Hobbs, A.J., Moore, P.K.

“…1 The effects of l‐NG‐monomethyl arginine (l‐NMMA) and l‐NG‐nitro arginine (l‐NOARG) on non‐adrenergic, non‐cholinergic (NANC) relaxations of the mouse…”
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