Search Results - "Moore, Michael D."

Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB-Independent Tissue-Resident Macrophages by Buchrieser, Julian, James, William, Moore, Michael D.

“…Tissue-resident macrophages, such as microglia, Kupffer cells, and Langerhans cells, derive from Myb-independent yolk sac (YS) progenitors generated before the…”
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MAIT cells are activated during human viral infections by van Wilgenburg, Bonnie, Scherwitzl, Iris, Hutchinson, Edward C., Leng, Tianqi, Kurioka, Ayako, Kulicke, Corinna, de Lara, Catherine, Cole, Suzanne, Vasanawathana, Sirijitt, Limpitikul, Wannee, Malasit, Prida, Young, Duncan, Denney, Laura, Moore, Michael D., Fabris, Paolo, Giordani, Maria Teresa, Oo, Ye Htun, Laidlaw, Stephen M., Dustin, Lynn B., Ho, Ling-Pei, Thompson, Fiona M., Ramamurthy, Narayan, Mongkolsapaya, Juthathip, Willberg, Christian B., Screaton, Gavin R., Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated…”
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CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells by Flynn, Rowan, Grundmann, Alexander, Renz, Peter, Hänseler, Walther, James, William S, Cowley, Sally A, Moore, Michael D

“…Chronic granulomatous disease (CGD) is a rare genetic disease characterized by severe and persistent childhood infections. It is caused by the lack of an…”
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Macrophage Infection via Selective Capture of HIV-1-Infected CD4+ T Cells by Baxter, Amy E., Russell, Rebecca A., Duncan, Christopher J.A., Moore, Michael D., Willberg, Christian B., Pablos, Jose L., Finzi, Andrés, Kaufmann, Daniel E., Ochsenbauer, Christina, Kappes, John C., Groot, Fedde, Sattentau, Quentin J.

“…Macrophages contribute to HIV-1 pathogenesis by forming a viral reservoir and mediating neurological disorders. Cell-free HIV-1 infection of macrophages is…”
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The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4 by van Wilgenburg, Bonnie, Moore, Michael D, James, William S, Cowley, Sally A

“…Macrophages constitute an important reservoir of HIV-1 infection, yet HIV-1 entry into these cells is poorly understood due to the difficulty in genetically…”
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SPCZ zonal events and downstream influence on surface ocean conditions in the Indonesian Throughflow region by Linsley, Braddock K., Wu, Henry C., Rixen, Tim, Charles, Christopher D., Gordon, Arnold L., Moore, Michael D.

“…Seasonal surface freshening of the Makassar Strait, the main conduit of the Indonesian Throughflow (ITF), is a key factor controlling the ITF. Here we present…”
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Probing the HIV-1 genomic RNA trafficking pathway and dimerization by genetic recombination and single virion analyses by Moore, Michael D, Nikolaitchik, Olga A, Chen, Jianbo, Hammarskjöld, Marie-Louise, Rekosh, David, Hu, Wei-Shau

“…Once transcribed, the nascent full-length RNA of HIV-1 must travel to the appropriate host cell sites to be translated or to find a partner RNA for copackaging…”
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Dimer Initiation Signal of Human Immunodeficiency Virus Type 1: Its Role in Partner Selection during RNA Copackaging and Its Effects on Recombination by MOORE, Michael D, FU, William, NIKOLAITCHIK, Olga, JIANBO CHEN, PTAK, Roger G, HU, Wei-Shau

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Intramolecular Oxonium Ylide Formation–[2,3] Sigmatropic Rearrangement of Diazocarbonyl-Substituted Cyclic Unsaturated Acetals: A Formal Synthesis of Hyperolactone C by Hodgson, David M, Man, Stanislav, Powell, Kimberley J, Perko, Ziga, Zeng, Minxiang, Moreno-Clavijo, Elena, Thompson, Amber L, Moore, Michael D

“…Rh­(II)-catalyzed oxonium ylide formation–[2,3] sigmatropic rearrangement of α-diazo-β-ketoesters possessing γ-cyclic unsaturated acetal substitution, followed…”
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Foamy Virus Bet Proteins Function as Novel Inhibitors of the APOBEC3 Family of Innate Antiretroviral Defense Factors by RUSSELL, Rebecca A, WIEGAND, Heather L, MOORE, Michael D, SCHÄFER, Alexandra, MCCLURE, Myra O, CULLEN, Bryan R

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APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA by Russell, Rebecca A, Moore, Michael D, Hu, Wei-Shau, Pathak, Vinay K

“…Naturally occurring Vif variants that are unable to inhibit the host restriction factor APOBEC3G (A3G) have been isolated from infected individuals. A3G can…”
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Towards an understanding of the structurally based potential for mechanically activated disordering of small molecule organic crystals by Wildfong, Peter L D, Hancock, Bruno C, Moore, Michael D, Morris, Kenneth R

“…The potential for various small molecule organic crystals to undergo complete mechanically induced disordering is investigated. A model is proposed, which…”
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Delineation of the Preferences and Requirements of the Human Immunodeficiency Virus Type 1 Dimerization Initiation Signal by Using an In Vivo Cell-Based Selection Approach by Hussein, Islam T M, Ni, Na, Galli, Andrea, Chen, Jianbo, Moore, Michael D, Hu, Wei-Shau

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Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: Effects on virion morphogenesis and RNA maturation by Moore, Michael D, Fu, William, Soheilian, Ferri, Nagashima, Kunio, Ptak, Roger G, Pathak, Vinay K, Hu, Wei-Shau

“…Abstract Protease activity within nascently released human immunodeficiency virus type 1 (HIV-1) particles is responsible for the cleavage of the viral…”
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RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation by Buchrieser, Julian, Oliva-Martin, Maria Jose, Moore, Michael D., Long, Joshua C. D., Cowley, Sally A., Perez-Simón, Jose Antonio, James, William, Venero, Jose Luis

“…In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate the potential roles of RIPK1 in…”
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Testing DNA barcodes against morphology for the ‘tripectinate Abantiades' (Lepidoptera: Hepialidae) reveals a complex relationship between COI sequence data and morphology by Simonsen, Thomas J, Moore, Michael D, Dupont, Steen T, Stevens, Mark I

“…We analyse COI sequence data from 140 specimens of the Australian ‘tripectinate‐Abantiades' to explore the group's molecular diversity and identify potential…”
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Three new ghost moths of the genus Oxycanus Walker, 1856 from Australia (Lepidoptera: Hepialidae) by Beaver, Ethan P, Moore, Michael D, Velasco-Castrillón, Alejandro, Stevens, Mark I

“…Three new species of ghost moth, Oxycanus ephemerous sp. nov., O. flavoplumosus sp. nov., and O. petalous sp. nov. are described from South Australia, New…”
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The nature and nurture of cell heterogeneity: accounting for macrophage gene-environment interactions with single-cell RNA-Seq by Wills, Quin F, Mellado-Gomez, Esther, Nolan, Rory, Warner, Damien, Sharma, Eshita, Broxholme, John, Wright, Benjamin, Lockstone, Helen, James, William, Lynch, Mark, Gonzales, Michael, West, Jay, Leyrat, Anne, Padilla-Parra, Sergi, Filippi, Sarah, Holmes, Chris, Moore, Michael D, Bowden, Rory

“…Single-cell RNA-Seq can be a valuable and unbiased tool to dissect cellular heterogeneity, despite the transcriptome's limitations in describing higher…”
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HIV-1 RNA dimerization: It takes two to tango by Moore, Michael D, Hu, Wei Shau

“…Each viral particle of HIV-1, the infectious agent of AIDS, contains two copies of the full-length viral genomic RNA. Encapsidating two copies of genomic RNA…”
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Informatics calibration of a molecular descriptors database to predict solid dispersion potential of small molecule organic solids by Moore, Michael D., Wildfong, Peter L.D.

“…The use of a novel, in silico method for making an intelligent polymer selection to physically stabilize small molecule organic (SMO) solid compounds…”
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