Search Results - "Moore, Malcolm A.S."

A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6 by BAUGHN, Linda B, DI LIBERTO, Maurizio, CHEN-KIANG, Selina, KAIDA WU, TOOGOOD, Peter L, LOUIE, Tracey, GOTTSCHALK, Rachel, NIESVIZKY, Ruben, CHO, Hearn, ELY, Scott, MOORE, Malcolm A. S

“…Cell cycle deregulation is central to the initiation and fatality of multiple myeloma, the second most common hematopoietic cancer, although impaired apoptosis…”
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Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth by Benezra, Robert, Rafii, Shahin, Lyden, David, Hattori, Koichi, Dias, Sergio, Costa, Carla, Blaikie, Pamela, Butros, Linda, Chadburn, Amy, Heissig, Beate, Marks, Willy, Witte, Larry, Wu, Yan, Hicklin, Daniel, Zhu, Zhenping, Hackett, Neil R, Crystal, Ronald G, Moore, Malcolm A.S, Hajjar, Katherine A, Manova, Katia

“…The role of bone marrow (BM)-derived precursor cells in tumor angiogenesis is not known. We demonstrate here that tumor angiogenesis is associated with…”
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Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1 + stem cells from bone-marrow microenvironment by Rafii, Shahin, Hattori, Koichi, Heissig, Beate, Wu, Yan, Dias, Sergio, Tejada, Rafael, Ferris, Barbara, Hicklin, Daniel J, Zhu, Zhenping, Bohlen, Peter, Witte, Larry, Hendrikx, Jan, Hackett, Neil R, Crystal, Ronald G, Moore, Malcolm A.S, Werb, Zena, Lyden, David

“…The mechanism by which angiogenic factors recruit bone marrow (BM)-derived quiescent endothelial and hematopoietic stem cells (HSCs) is not known. Here, we…”
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Enforced expression of NUP98-HOXA9 in human CD34+ cells enhances stem cell proliferation by CHUNG, Ki Y, MORRONE, Giovanni, SCHURINGA, Jan Jacob, PLASILOVA, Magdalena, SHIEH, Jae-Hung, YUE ZHANG, PENGBO ZHOU, MOORE, Malcolm A. S

“…The t(7;11)(p15;p15) translocation, observed in acute myelogenous leukemia and myelodysplastic syndrome, generates a chimeric gene where the 5' portion of the…”
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Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells by Moore, Malcolm A.S, Dorn, David C, Schuringa, Jan Jacob, Chung, Ki Young, Morrone, Giovanni

“…Objective To model human leukemogenesis by transduction of human hematopoietic stem cells (HSC) with genes associated with leukemia and expressed in leukemic…”
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Nrf2 regulates haematopoietic stem cell function by Tsai, Jennifer J., Dudakov, Jarrod A., Takahashi, Koichi, Shieh, Jae-Hung, Velardi, Enrico, Holland, Amanda M., Singer, Natalie V., West, Mallory L., Smith, Odette M., Young, Lauren F., Shono, Yusuke, Ghosh, Arnab, Hanash, Alan M., Tran, Hien T., Moore, Malcolm A. S., van den Brink, Marcel R. M.

“…Van den Brink and colleagues show that Nrf2, a regulator of the oxidative stress response, is required for several aspects of haematopoietic stem cell…”
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Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4 + T cells by Crystal, Ronald G, Kikuchi, Toshiaki, Worgall, Stefan, Singh, Ravi, Moore, Malcolm A.S

“…We have investigated whether dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can trigger B cells to produce…”
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Extracellular vesicles from human airway basal cells respond to cigarette smoke extract and affect vascular endothelial cells by Saxena, Ashish, Walters, Matthew S., Shieh, Jae-Hung, Shen, Ling-Bo, Gomi, Kazunori, Downey, Robert J., Crystal, Ronald G., Moore, Malcolm A. S.

“…The human airway epithelium lining the bronchial tree contains basal cells that proliferate, differentiate, and communicate with other components of their…”
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Increased plasma levels of stromal-derived factor-1 (SDF-1/CXCL12) enhance human thrombopoiesis and mobilize human colony-forming cells (CFC) in NOD/SCID mice by Perez, Lia E, Alpdogan, Onder, Shieh, Jae-Hung, Wong, Donald, Merzouk, Ahmed, Salari, Hassan, O'Reilly, Richard J, van den Brink, Marcel R.M, Moore, Malcolm A.S

“…Stromal-derived factor-1 (SDF-1/CXCL12) is chemotactic for lympho/hematopoietic stem cells. We have previously shown that increasing peripheral blood (PB)…”
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Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand by Heissig, Beate, Hattori, Koichi, Dias, Sergio, Friedrich, Matthias, Ferris, Barbara, Hackett, Neil R., Crystal, Ronald G., Besmer, Peter, Lyden, David, Moore, Malcolm A.S., Werb, Zena, Rafii, Shahin

“…Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate and mobilize to circulation following specific signals…”
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AAV-mediated persistent bevacizumab therapy suppresses tumor growth of ovarian cancer by Xie, Yi, Hicks, Martin J, Kaminsky, Stephen M, Moore, Malcolm A.S, Crystal, Ronald G, Rafii, Arash

“…Abstract Rationale Anti-angiogenesis therapies such as bevacizumab, the monoclonal antibody to vascular endothelial growth factor (VEGF), have been used…”
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Waking up HSCs: a new role for E-selectin by Moore, Malcolm A S

“…Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the bone marrow, but a distinct function for each of these niches has remained…”
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Tunneling Nanotubes: A new paradigm for studying intercellular communication and therapeutics in cancer by Lou, Emil, Fujisawa, Sho, Barlas, Afsar, Romin, Yevgeniy, Manova-Todorova, Katia, Moore, Malcolm A.S., Subramanian, Subbaya

“…Tunneling nanotubes are actin-based cytoplasmic extensions that function as intercellular channels in a wide variety of cell types.There is a renewed and keen…”
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High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells by Pera, Benet, Calvo-Vidal, M. Nieves, Ambati, Srikanth, Jordi, Michel, Kahn, Alissa, Díaz, J. Fernando, Fang, Weishuo, Altmann, Karl-Heinz, Cerchietti, Leandro, Moore, Malcolm A.S

“…Highlights • Drug efflux via membrane pumps is a resistant mechanism behind AML treatment failure. • Molecules with high affinity or covalent binding overcome…”
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Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma by Ambati, Srikanth R., Lopes, Eloisi Caldas, Kosugi, Kohji, Mony, Ullas, Zehir, Ahmet, Shah, Smit K., Taldone, Tony, Moreira, Andre L., Meyers, Paul A., Chiosis, Gabriela, Moore, Malcolm A.S.

“…Ewing sarcoma is characterized by multiple deregulated pathways that mediate cell survival and proliferation. Heat shock protein 90 (HSP90) is a critical…”
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Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells by Hattori, K, Dias, S, Heissig, B, Hackett, N R, Lyden, D, Tateno, M, Hicklin, D J, Zhu, Z, Witte, L, Crystal, R G, Moore, M A, Rafii, S

“…Tyrosine kinase receptors for angiogenic factors vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1) are expressed not only by endothelial…”
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Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium by Gabrilove, J L, Jakubowski, A, Scher, H, Sternberg, C, Wong, G, Grous, J, Yagoda, A, Fain, K, Moore, M A, Clarkson, B

“…We evaluated the ability of human recombinant granulocyte colony-stimulating factor (rhG-CSF) to prevent chemotherapy-induced neutropenia or to accelerate…”
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KIT Receptor Gain‐of‐Function in Hematopoiesis Enhances Stem Cell Self‐Renewal and Promotes Progenitor Cell Expansion by Deshpande, Shayu, Bosbach, Benedikt, Yozgat, Yasemin, Park, Christopher Y., Moore, Malcolm A.S., Besmer, Peter

“…The KIT receptor tyrosine kinase has important roles in hematopoiesis. We have recently produced a mouse model for imatinib resistant gastrointestinal stromal…”
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The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by Stromal Cell-Derived Factor-1 by Möhle, Robert, Bautz, Frank, Rafii, Shahin, Moore, Malcolm A.S., Brugger, Wolfram, Kanz, Lothar

“…The chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR-4 (fusin, LESTR) are likely to be involved in the trafficking of hematopoietic…”
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The effect of cantharidins on leukemic stem cells by Dorn, David C., Kou, Cynthia A., Png, Kim J., Moore, Malcolm A.S.

“…To identify an agent with specific activity against leukemic stem cells (LSCs), we evaluated compounds that targeted hepatic leukemia factor (HLF), a gene…”
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