Search Results - "Moore, Kat"

RNA Binding Proteins and Regulation of mRNA Translation in Erythropoiesis by Moore, Kat S, von Lindern, Marieke

“…Control of gene expression in erythropoiesis has to respond to signals that may emerge from intracellular processes or environmental factors. Control of mRNA…”
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Pancreatic cancer organoids recapitulate disease and allow personalized drug screening by Driehuis, Else, van Hoeck, Arne, Moore, Kat, Kolders, Sigrid, Francies, Hayley E., Gulersonmez, M. Can, Stigter, Edwin C. A., Burgering, Boudewijn, Geurts, Veerle, Gracanin, Ana, Bounova, Gergana, Morsink, Folkert H., Vries, Robert, Boj, Sylvia, van Es, Johan, Offerhaus, G. Johan A., Kranenburg, Onno, Garnett, Mathew J., Wessels, Lodewyk, Cuppen, Edwin, Brosens, Lodewijk A. A., Clevers, Hans

“…We report the derivation of 30 patient-derived organoid lines (PDOs) from tumors arising in the pancreas and distal bile duct. PDOs recapitulate tumor…”
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Tumour-educated platelets for breast cancer detection: biological and technical insights by Liefaard, Marte C., Moore, Kat S., Mulder, Lennart, van den Broek, Daan, Wesseling, Jelle, Sonke, Gabe S., Wessels, Lodewyk F. A., Rookus, Matti, Lips, Esther H.

“…Background Studies have shown that blood platelets contain tumour-specific mRNA profiles tumour-educated platelets (TEPs). Here, we aim to train a TEP-based…”
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Computational approaches for the analysis of RNA–protein interactions: A primer for biologists by Moore, Kat S., 't Hoen, Peter A.C.

“…RNA-binding proteins (RBPs) play important roles in the control of gene expression and the coordination of different layers of post-transcriptional regulation…”
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Strap associates with Csde1 and affects expression of select Csde1-bound transcripts by Moore, Kat S, Yagci, Nurcan, van Alphen, Floris, Meijer, Alexander B, 't Hoen, Peter A C, von Lindern, Marieke

“…Erythropoiesis is regulated at many levels, including control of mRNA translation. Changing environmental conditions, such as hypoxia or the availability of…”
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Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors by Paolini, Nahuel A, Moore, Kat S, di Summa, Franca M, Fokkema, Ivo F A C, 't Hoen, Peter A C, von Lindern, Marieke

“…The regulation of translation initiation factor 2 (eIF2) is important for erythroid survival and differentiation. Lack of iron, a critical component of heme…”
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Correction To: Tumour-educated platelets for breast cancer detection: biological and technical insights by Liefaard, Marte C., Moore, Kat S., Mulder, Lennart, van den Broek, Daan, Wesseling, Jelle, Sonke, Gabe S., Wessels, Lodewyk F. A., Rookus, Matti, Lips, Esther H.

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TLR4 and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2, PI3Kβ, SGK1, and FOXO transcription factors by Zaal, Anouk, Nota, Benjamin, Moore, Kat S., Dieker, Miranda, Ham, S. Marieke, Brinke, Anja

“…Identification of a central regulatory network formed by FOXO1, FOXO3, RSK2, PI3Kβ2, and SGK1 upon C5aR and TLR4 crosstalk in human monocyte‐derived DCs…”
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The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression by Hansen, Marten, Zeddies, Sabrina, Meinders, Marjolein, di Summa, Franca, van Alphen, Floris P J, Hoogendijk, Arjan J, Moore, Kat S, Halbach, Melanie, Gutiérrez, Laura, van den Biggelaar, Maartje, Thijssen-Timmer, Daphne C, Auburger, Georg W J, van den Akker, Emile, von Lindern, Marieke, Rollmann, Ewa

“…Megakaryopoiesis is the process during which megakaryoblasts differentiate to polyploid megakaryocytes that can subsequently shed thousands of platelets in the…”
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Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line by Moore, Kat S., Yagci, Nurcan, van Alphen, Floris, Paolini, Nahuel A., Horos, Rastislav, Held, Ntsiki M., Houtkooper, Riekelt H., van den Akker, Emile, Meijer, Alexander B., ‘t Hoen, Peter A. C., von Lindern, Marieke

“…Expression of the RNA-binding protein Csde1 (Cold shock domain protein e1) is strongly upregulated during erythropoiesis compared to other hematopoietic…”
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Predicting patient response with models trained on cell lines and patient-derived xenografts by nonlinear transfer learning by Mourragui, Soufiane M. C., Loog, Marco, Vis, Daniel J., Moore, Kat, Manjon, Anna G., van de Wiel, Mark A., Reinders, Marcel J. T., Wessels, Lodewyk F. A.

“…Preclinical models have been the workhorse of cancer research, producing massive amounts of drug response data. Unfortunately, translating response biomarkers…”
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Poor Outcome in Postpartum Breast Cancer Patients Is Associated with Distinct Molecular and Immunologic Features by Lefrère, Hanne, Moore, Kat, Floris, Giuseppe, Sanders, Joyce, Seignette, Iris M., Bismeijer, Tycho, Peters, Dennis, Broeks, Annegien, Hooijberg, Erik, Van Calsteren, Kristel, Neven, Patrick, Warner, Ellen, Peccatori, Fedro Alessandro, Loibl, Sibylle, Maggen, Charlotte, Han, Sileny N., Jerzak, Katarzyna J., Annibali, Daniela, Lambrechts, Diether, de Visser, Karin E., Wessels, Lodewyk, Lenaerts, Liesbeth, Amant, Frédéric

“…Abstract Purpose: Patients with postpartum breast cancer diagnosed after cessation of breastfeeding (postweaning, PP-BCPW) have a particularly poor prognosis…”
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Tumor-educated platelets for breast cancer detection: Biological and technical insights by Liefaard, Marte C., Moore, Kat, Best, Myron, Sol, Nik, In 't Veld, Sjors G.J.G., Sonke, Gabe S., Tannous, Bakhos A., Wurdinger, Thomas, Rookus, Matti A., Wessels, Lodewyk F.A., Lips, Esther H.

“…Abstract only 3031 Background: Mammographic screening has enabled early detection of breast cancer, both in a general population and in women with increased…”
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Ribosome Profiling Uncovers Selective mRNA Translation Associated with eIF2 Phosphorylation in Erythrocyte Progenitors by Nahuel, Paolini, Kat, Moore, Franca, di Summa, Ivo, Fokkema, Sjoert, Jansen, Peter-Bram, 't Hoen, Von Lindern, Marieke

“…To keep circulating erythrocytes between narrow boundaries, the erythroid progenitor compartment has a large expansion capacity, that is tightly regulated by…”
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Poor outcome in postpartum breast cancer patients is associated with distinct molecular and immunological features by Lefrère, Hanne, Moore, Kat, Floris, Giuseppe, Sanders, Joyce, Seignette, Iris M, Bismeijer, Tycho, Peters, Dennis, Broeks, Annegien, Hooijberg, Erik, Van Calsteren, Kristel, Neven, Patrick, Warner, Ellen, Peccatori, Fedro Alessandro, Loibl, Sibylle, Maggen, Charlotte, Han, Sileny N, Jerzak, Katarzyna J, Annibali, Daniela, Lambrechts, Diether, de Visser, Karin E, Wessels, Lodewyk, Lenaerts, Liesbeth, Amant, Frédéric

“…Postpartum breast cancer patients diagnosed after cessation of breastfeeding (post-weaning, PP-BCPW), have a particularly poor prognosis compared to patients…”
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