Search Results - "Moore, Joseph B."

Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations by Moradi, Sharif, Mahdizadeh, Hamid, Šarić, Tomo, Kim, Johnny, Harati, Javad, Shahsavarani, Hosein, Greber, Boris, Moore, 4th, Joseph B

“…Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate into all specialized cell types including gametes. iPSCs do not…”
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Functional characterization of long noncoding RNAs by Moore, Joseph B., Uchida, Shizuka

“…PURPOSE OF REVIEWMounting evidence suggests that long noncoding RNAs (lncRNAs) are essential regulators of gene expression. Although few lncRNAs have been the…”
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Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases by Bonnet, Sébastien, Boucherat, Olivier, Paulin, Roxane, Wu, Danchen, Hindmarch, Charles C T, Archer, Stephen L, Song, Rui, Moore, 4th, Joseph B, Provencher, Steeve, Zhang, Lubo, Uchida, Shizuka

“…Although a majority of the mammalian genome is transcribed to RNA, mounting evidence indicates that only a minor proportion of these transcriptional products…”
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Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice by Kang, Yi, Nasr, Marjan, Guo, Yiru, Uchida, Shizuka, Weirick, Tyler, Li, Hong, Kim, Jae, Moore, Joseph B., Muthusamy, Senthilkumar, Bolli, Roberto, Wysoczynski, Marcin

“…Although cardiac mesenchymal cell (CMC) therapy mitigates post-infarct cardiac dysfunction, the underlying mechanisms remain unidentified. It is acknowledged…”
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C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK Pathways by Vajravelu, Bathri N, Hong, Kyung U, Al-Maqtari, Tareq, Cao, Pengxiao, Keith, Matthew C L, Wysoczynski, Marcin, Zhao, John, Moore, 4th, Joseph B, Bolli, Roberto

“…A recent phase I clinical trial (SCIPIO) has shown that autologous c-kit+ cardiac progenitor cells (CPCs) improve cardiac function and quality of life when…”
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Matricellular protein CCN1 promotes collagen alignment and scar integrity after myocardial infarction by Fischer, Annalara G., Elliott, Erin M., Brittian, Kenneth R., Garrett, Lauren, Sadri, Ghazal, Aebersold, Julia, Singhal, Richa A., Nong, Yibing, Leask, Andrew, Jones, Steven P., Moore IV, Joseph B.

“…•Fibroblast-specific ablation of CCN1 neither impacts cardiac function nor myocardial collagen levels; however, it disrupts collagen fibril organization and…”
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Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles by Hosen, Mohammed Rabiul, Goody, Philip Roger, Zietzer, Andreas, Xiang, Xu, Niepmann, Sven Thomas, Sedaghat, Alexander, Tiyerili, Vedat, Chennupati, Ramesh, Moore, Joseph B., Boon, Reinier A., Uchida, Shizuka, Sinning, Jan-Malte, Zimmer, Sebastian, Latz, Eicke, Werner, Nikos, Nickenig, Georg, Jansen, Felix

“…Transcatheter aortic valve replacement (TAVR) is a well-established treatment option for high- and intermediate-risk patients with severe symptomatic aortic…”
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Myocardial Reparative Properties of Cardiac Mesenchymal Cells Isolated on the Basis of Adherence by Wysoczynski, Marcin, PhD, Guo, Yiru, MD, Moore, Joseph B., PhD, Muthusamy, Senthilkumar, PhD, Li, Qianhong, MD, PhD, Nasr, Marjan, MS, Li, Hong, PhD, Nong, Yibing, MD, Wu, Wenjian, MD, Tomlin, Alex A., BS, Zhu, Xiaoping, MD, Hunt, Gregory, BS, Gumpert, Anna M., PhD, Book, Michael J., MS, Khan, Abdur, MD, Tang, Xian-Liang, MD, Bolli, Roberto, MD

“…Abstract Background The authors previously reported that the c-kit–positive (c-kitPOS ) cells isolated from slowly adhering (SA) but not from rapidly adhering…”
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Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism by Dwenger, Marc M., Raph, Sean M., Reyzer, Michelle L., Lisa Manier, M., Riggs, Daniel W., Wohl, Zachary B., Ohanyan, Vahagn, Mack, Gregory, Pucci, Thomas, Moore, Joseph B., Hill, Bradford G., Chilian, William M., Caprioli, Richard M., Bhatnagar, Aruni, Nystoriak, Matthew A.

“…Adequate oxygen delivery to the heart during stress is essential for sustaining cardiac function. Acute increases in myocardial oxygen demand evoke coronary…”
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The A-to-I RNA Editing Enzyme Adar1 Is Essential for Normal Embryonic Cardiac Growth and Development by Moore, Joseph B., Sadri, Ghazal, Fischer, Annalara G., Weirick, Tyler, Militello, Giuseppe, Wysoczynski, Marcin, Gumpert, Anna M., Braun, Thomas, Uchida, Shizuka

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Transcription factor-induced activation of cardiac gene expression in human c-kit+ cardiac progenitor cells by Al-Maqtari, Tareq, Hong, Kyung U, Vajravelu, Bathri N, Moktar, Afsoon, Cao, Pengxiao, Moore, 4th, Joseph B, Bolli, Roberto

“…Although transplantation of c-kit+ cardiac progenitor cells (CPCs) significantly alleviates post-myocardial infarction left ventricular dysfunction, generation…”
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Predictors and clinical impact of pre-existing and acquired thrombocytopenia following transcatheter aortic valve replacement by Flaherty, Michael P., Mohsen, Amr, Moore, Joseph B., Bartoli, Carlo R., Schneibel, Erik, Rawasia, Wasiq, Williams, Matthew L., Grubb, Kendra J., Hirsch, Glenn A.

“…Background Data are limited regarding transcatheter aortic valve replacement (TAVR)‐related thrombocytopenia (TP). We sought to thoroughly characterize the…”
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Effect of Molecular Weight on Sonoporation-Mediated Uptake in Human Cells by Bhutto, Danyal F., Murphy, Emily M., Priddy, Mariah C., Centner, Connor C., Moore IV, Joseph B., Bolli, Roberto, Kopechek, Jonathan A.

“…Ultrasound-induced microbubble destruction can enhance drug delivery to cells. The molecular weight of therapeutic compounds varies significantly (from <1 kDa…”
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Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment After Transplantation by Adamiak, Mateusz, Moore, 4th, Joseph B, Zhao, John, Abdelbaset-Ismail, Ahmed, Grubczak, Kamil, Rzeszotek, Sylwia, Wysoczynski, Marcin, Ratajczak, Mariusz Z

“…Heme oxygenase 1 (HO-1) is an inducible stress-response enzyme that not only catalyzes the degradation of heme (e.g., released from erythrocytes) but also has…”
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Macrophage Long Non-Coding RNAs in Pathogenesis of Cardiovascular Disease by Wysoczynski, Marcin, Kim, Jae, Moore, 4th, Joseph B, Uchida, Shizuka

“…Chronic inflammation is inextricably linked to cardiovascular disease (CVD). Macrophages themselves play important roles in atherosclerosis, as well as acute…”
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Epigenetically modified cardiac mesenchymal stromal cells limit myocardial fibrosis and promote functional recovery in a model of chronic ischemic cardiomyopathy by Moore, Joseph B., Tang, Xian-Liang, Zhao, John, Fischer, Annalara G., Wu, Wen-Jian, Uchida, Shizuka, Gumpert, Anna M., Stowers, Heather, Wysoczynski, Marcin, Bolli, Roberto

“…Preclinical investigations support the concept that donor cells more oriented towards a cardiovascular phenotype favor repair. In light of this philosophy, we…”
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Airn Regulates Igf2bp2 Translation in Cardiomyocytes by Hosen, Mohammed Rabiul, Militello, Giuseppe, Weirick, Tyler, Ponomareva, Yuliya, Dassanayaka, Sujith, Moore, Joseph B, Döring, Claudia, Wysoczynski, Marcin, Jones, Steven P, Dimmeler, Stefanie, Uchida, Shizuka

“…RATIONALE:Increasing evidence indicates the presence of lncRNAs in various cell types. Airn is an imprinting gene transcribed from the paternal chromosome. It…”
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Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins by Ohanyan, Vahagn, Raph, Sean M., Dwenger, Marc M., Hu, Xuemei, Pucci, Thomas, Mack, Gregory, Moore, Joseph B., Chilian, William M., Bhatnagar, Aruni, Nystoriak, Matthew A.

“…[Figure: see text]…”
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Histone Deacetylase 1 Depletion Activates Human Cardiac Mesenchymal Stromal Cell Proangiogenic Paracrine Signaling Through a Mechanism Requiring Enhanced Basic Fibroblast Growth Factor Synthesis and Secretion by Moore, Joseph B., Zhao, John, Fischer, Annalara G., Keith, Matthew C.L., Hagan, David, Wysoczynski, Marcin, Bolli, Roberto

“…Background Cardiac mesenchymal cell (CMC) administration improves cardiac function in animal models of heart failure. Although the precise mechanisms remain…”
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Recent Developments in Stem and Progenitor Cell Therapy for Cardiac Repair by Zhao, John, Ghafghazi, Shahab, Khan, Abdur Rahman, Farid, Talha Ahmad, Moore, Joseph B

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