Search Results - "Moore, Jonathan M."

From Nanodiscs to Isotropic Bicelles: A Procedure for Solution Nuclear Magnetic Resonance Studies of Detergent-Sensitive Integral Membrane Proteins by Laguerre, Aisha, Löhr, Frank, Henrich, Erik, Hoffmann, Beate, Abdul-Manan, Norzehan, Connolly, Peter J., Perozo, Eduardo, Moore, Jonathan M., Bernhard, Frank, Dötsch, Volker

“…Nanodiscs and isotropic bicelles are promising membrane mimetics in the field of solution nuclear magnetic resonance (NMR) spectroscopy of integral membrane…”
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Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism by ter Haar, Ernst, Koth, Christopher M., Abdul-Manan, Norzehan, Swenson, Lora, Coll, Joyce T., Lippke, Judith A., Lepre, Christopher A., Garcia-Guzman, Miguel, Moore, Jonathan M.

“…Dysregulation of the calcitonin gene-related peptide (CGRP), a potent vasodilator, is directly implicated in the pathogenesis of migraine. CGRP binds to and…”
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Theory and Applications of NMR-Based Screening in Pharmaceutical Research by Lepre, Christopher A, Moore, Jonathan M, Peng, Jeffrey W

“…Lepre et al focus on both theoretical aspects and practical considerations for the most commonly used NMR-based screening approaches, combining literature…”
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Time-shared experiments for efficient assignment of triple-selectively labeled proteins by Löhr, Frank, Laguerre, Aisha, Bock, Christoph, Reckel, Sina, Connolly, Peter J., Abdul-Manan, Norzehan, Tumulka, Franz, Abele, Rupert, Moore, Jonathan M., Dötsch, Volker

“…[Display omitted] •New experiments improve residue-type distinction in selectively labeled proteins.•Combined acquisition of 2D HN(CX) triple-resonance spectra…”
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Refolding and Characterization of a Soluble Ectodomain Complex of the Calcitonin Gene-Related Peptide Receptor by Koth, Christopher M, Abdul-Manan, Norzehan, Lepre, Christopher A, Connolly, Peter J, Yoo, Sanghee, Mohanty, Arun K, Lippke, Judith A, Zwahlen, Jacque, Coll, Joyce T, Doran, John D, Garcia-Guzman, Miguel, Moore, Jonathan M

“…The calcitonin gene-related peptide (CGRP) receptor is a heterodimer of two membrane proteins: calcitonin receptor-like receptor (CLR) and receptor…”
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Combinatorial triple-selective labeling as a tool to assist membrane protein backbone resonance assignment by Löhr, Frank, Reckel, Sina, Karbyshev, Mikhail, Connolly, Peter J., Abdul-Manan, Norzehan, Bernhard, Frank, Moore, Jonathan M., Dötsch, Volker

“…Obtaining NMR assignments for slowly tumbling molecules such as detergent-solubilized membrane proteins is often compromised by low sensitivity as well as…”
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ABC transporters: human disease and pharmacotherapeutic potential by Moore, Jonathan M., Bell, Eric L., Hughes, Robert O., Garfield, Alastair S.

“…ABC transporters are a 48-member superfamily of membrane proteins that move substrates across lipid membranes and have broad biological relevance based on…”
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NMR techniques for characterization of ligand binding: Utility for lead generation and optimization in drug discovery by Moore, Jonathan M.

“…Over the last ten years, nmr spectroscopy has evolved into an important discipline in drug discovery. Initially, nmr was most useful as a technique to provide…”
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Microdrop screening: a rapid method to optimize solvent conditions for NMR spectroscopy of proteins by Lepre, C A, Moore, J M

“…Determining appropriate solvent conditions is a crucial first step for carrying out NMR spectroscopy of proteins, but rapid and efficient methods for doing so…”
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Solution structure of the major binding protein for the immunosuppressant FK506 by Moore, Jonathan M, Peattie, Debra A, Fitzgibbon, Matthew J, Thomson, John A

“…The major FK506 binding protein (FKBP, relative molecular mass approximately 11,800; Mr 11.8K) and cyclophilin (Mr approximately 17K) belong to a class of…”
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NMR screening in drug discovery by Moore, J M

“…NMR methods in drug discovery have traditionally been used to obtain structural information for drug targets or target-ligand complexes. Recently, it has been…”
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Application of NMR SHAPES Screening to an RNA Target by Johnson, Eric C, Feher, Victoria A, Peng, Jeffrey W, Moore, Jonathan M, Williamson, James R

“…Several NMR screening techniques have been developed in recent years to aid in the identification of lead drug compounds. These NMR methods have traditionally…”
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The SHAPES strategy: an NMR-based approach for lead generation in drug discovery by Fejzo, Jasna, Lepre, Christopher A, Peng, Jeffrey W, Bemis, Guy W, Ajay, Murcko, Mark A, Moore, Jonathan M

“…Background: Recently, it has been shown that nuclear magnetic resonance (NMR) may be used to identify ligands that bind to low molecular weight protein drug…”
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Applications of SHAPES screening in drug discovery by Lepre, Christopher A, Peng, Jeffrey, Fejzo, Jasna, Abdul-Manan, Norzehan, Pocas, Jennifer, Jacobs, Marc, Xie, Xiaoling, Moore, Jonathan M

“…The SHAPES strategy combines nuclear magnetic resonance (NMR) screening of a library of small drug-like molecules with a variety of complementary methods, such…”
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15N NMR Relaxation Studies of the FK506 Binding Protein: Dynamic Effects of Ligand Binding and Implications for Calcineurin Recognition by Cheng, Jya-Wei, Lepre, Christopher A, Moore, Jonathan M

“…Backbone dynamics of the ligand- (FK506-) bound protein FKBP-12 (107 amino acids) have been examined using 15N relaxation data derived from inverse-detected…”
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From nanodiscs to isotropic bicelles: a procedure for solution NMR studies of detergent sensitive integral membrane proteins by Laguerre, Aisha, Löhr, Frank, Henrich, Erik, Hoffmann, Beate, Abdul-Manan, Norzehan, Connolly, Peter J., Perozo, Eduardo, Moore, Jonathan M., Bernhard, Frank, Dötsch, Volker

“…Nanodiscs and isotropic bicelles are promising membrane mimetics in the field of solution NMR spectroscopy of integral membrane proteins (IMPs). Despite varied…”
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Dynamics of a receptor-bound ligand by heteronuclear NMR: FK506 bound to FKBP-12 by Lepre, Christopher A, Cheng, Jya Wei, Moore, Jonathan M

“…FK506 is a potent immunosuppressant that inhibits T-cell activation by blocking early steps in cytoplasmic signal transduction. The complex formed by FK506 and…”
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Three-dimensional solution structure of plastocyanin from the green alga Scenedesmus obliquus by Moore, J.M, Case, D.A, Chazin, W.J, Gippert, G.P, Havel, T.F, Powls, R, Wright, P.E

“…The solution conformation of plastocyanin from the green alga Scenedesmus obliquus has been determined from distance and dihedral angle constraints derived by…”
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Solution Structure of FK506 Bound to the R42K, H87V Double Mutant of FKBP-12 by Lepre, Christopher A, Pearlman, David A, Cheng, Jya-Wei, DeCenzo, Maureen T, Moore, Jonathan M, Livingston, David J

“…The binding of the FK506/FKBP-12 complex to calcineurin (CN), its putative target for immunosuppression, involves recognition of solvent-exposed regions of the…”
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Nitrogen-15 NMR relaxation studies of the FK506 binding protein: Backbone dynamics of the uncomplexed receptor by Cheng, Jya Wei, Lepre, Christopher A, Chambers, Stephen P, Fulghum, John R, Thomson, John A, Moore, Jonathan M

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