Search Results - "Moore, Hunter B"

Tissue plasminogen activator (tPA) treatment for COVID‐19 associated acute respiratory distress syndrome (ARDS): A case series by Wang, Janice, Hajizadeh, Negin, Moore, Ernest E., McIntyre, Robert C., Moore, Peter K., Veress, Livia A., Yaffe, Michael B., Moore, Hunter B., Barrett, Christopher D.

“…A prothrombotic coagulopathy is commonly found in critically ill COVID‐19 patients with acute respiratory distress syndrome (ARDS). A unique feature of…”
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Fibrinolysis Shutdown in COVID-19: Clinical Manifestations, Molecular Mechanisms, and Therapeutic Implications by Meizoso, Jonathan P., Moore, Hunter B., Moore, Ernest E.

“…The COVID-19 pandemic has introduced a global public health threat unparalleled in our history. The most severe cases are marked by ARDS attributed to…”
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Acute Fibrinolysis Shutdown after Injury Occurs Frequently and Increases Mortality: A Multicenter Evaluation of 2,540 Severely Injured Patients by Moore, Hunter B., MD, Moore, Ernest E., MD, FACS, Liras, Ioannis N., MD, Gonzalez, Eduardo, MD, Harvin, John A., FACS, MD, Holcomb, John B., MD, FACS, Sauaia, Angela, MD, PhD, Cotton, Bryan A., MD, MPH, FACS

“…Background Fibrinolysis is a physiologic process that maintains microvascular patency by breaking down excessive fibrin clot. Hyperfibrinolysis is associated…”
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Management of Trauma-Induced Coagulopathy with Thrombelastography by Gonzalez, Eduardo, MD, Moore, Ernest E., MD, Moore, Hunter B., MD

“…Viscoelastic assays, such as thrombelastography (TEG) and rotational thrombelastometry (ROTEM), have emerged as point-of-care tools that can guide the…”
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Fibrinolysis Shutdown in Trauma: Historical Review and Clinical Implications by Moore, Hunter B., Moore, Ernest E., Neal, Matthew D., Sheppard, Forest R., Kornblith, Lucy Z., Draxler, Dominik F., Walsh, Mark, Medcalf, Robert L., Cohen, Mitch J., Cotton, Bryan A., Thomas, Scott G., Leeper, Christine M., Gaines, Barbara A., Sauaia, Angela

“…Despite over a half-century of recognizing fibrinolytic abnormalities after trauma, we remain in our infancy in understanding the underlying mechanisms causing…”
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Redefining postinjury fibrinolysis phenotypes using two viscoelastic assays by Stettler, Gregory R, Moore, Ernest E, Moore, Hunter B, Nunns, Geoffrey R, Silliman, Christopher C, Banerjee, Anirban, Sauaia, Angela

“…Fibrinolysis was initially defined using rapid thrombelastography (rTEG). The cutoffs for the pathologic extremes of the fibrinolytic system, hyperfibrinolysis…”
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Goal-directed hemostatic resuscitation for trauma induced coagulopathy: Maintaining homeostasis by Moore, Ernest E, Moore, Hunter B, Chapman, Michael P, Gonzalez, Eduardo, Sauaia, Angela

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Rapid thrombelastography thresholds for goal-directed resuscitation of patients at risk for massive transfusion by Einersen, Peter M, Moore, Ernest E, Chapman, Michael P, Moore, Hunter B, Gonzalez, Eduardo, Silliman, Christopher C, Banerjee, Anirban, Sauaia, Angela

“…Uncontrolled hemorrhage is a leading cause of mortality after trauma accounting for up to 40% of deaths. Massive transfusion protocols offer a proven benefit…”
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Does Tranexamic Acid Improve Clot Strength in Severely Injured Patients Who Have Elevated Fibrin Degradation Products and Low Fibrinolytic Activity, Measured by Thrombelastography? by Moore, Hunter B., Moore, Ernest E., Chapman, Michael P., Hansen, Kirk C., Cohen, Mitchell J., Pieracci, Frederic M., Chandler, James, Sauaia, Angela

“…Elevated d-dimers in injured patients with paradoxically low fibrinolysis activity measured by viscoelastic assays have been speculated to be “occult”…”
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Tranexamic acid is associated with increased mortality in patients with physiological fibrinolysis by Moore, Hunter B., MD, Moore, Ernest E., MD, Huebner, Benjamin R., MD, Stettler, Gregory R., MD, Nunns, Geoffrey R., MD, Einersen, Peter M., MD, Silliman, Christopher C., MD, PhD, Sauaia, Angela, MD, PhD

“…Abstract Background Tranexamic acid (TXA) administration after trauma has not been proven to improve survival in the United States. Trauma patients were…”
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Plasmin thrombelastography rapidly identifies trauma patients at risk for massive transfusion, mortality, and hyperfibrinolysis: A diagnostic tool to resolve an international debate on tranexamic acid? by Barrett, Christopher D., Moore, Hunter B., Vigneshwar, Navin, Dhara, Sanjeev, Chandler, James, Chapman, Michael P., Sauaia, Angela, Moore, Ernest E., Yaffe, Michael B.

“…Trauma patients with hyperfibrinolysis and depletion of fibrinolytic inhibitors (DFIs) measured by thrombelastography (TEG) gain clot strength with TXA, but…”
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Computational model of tranexamic acid on urokinase mediated fibrinolysis by Wu, Tie Bo, Orfeo, Thomas, Moore, Hunter B, Sumislawski, Joshua J, Cohen, Mitchell J, Petzold, Linda R

“…Understanding the coagulation process is critical to developing treatments for trauma and coagulopathies. Clinical studies on tranexamic acid (TXA) have…”
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Development and in-vivo validation of a portable phosphorescence lifetime-based fiber-optic oxygen sensor by Witthauer, Lilian, Roussakis, Emmanuel, Cascales, Juan Pedro, Goss, Avery, Li, Xiaolei, Cralley, Alexis, Yoeli, Dor, Moore, Hunter B., Wang, Zhaohui, Wang, Yong, Li, Bing, Huang, Christene A., Moore, Ernest E., Evans, Conor L.

“…Oxygenation is a crucial indicator of tissue viability and function. Oxygen tension ( pO 2 ), i.e. the amount of molecular oxygen present in the tissue is a…”
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Shock-induced systemic hyperfibrinolysis is attenuated by plasma-first resuscitation by Moore, Hunter B, Moore, Ernest E, Morton, Alexander P, Gonzalez, Eduardo, Fragoso, Miguel, Chapman, Michael P, Dzieciatkowska, Monika, Hansen, Kirk C, Banerjee, Anirban, Sauaia, Angela, Silliman, Christopher C

“…We developed a hemorrhagic shock animal model to replicate an urban prehospital setting where resuscitation fluids are limited to assess the effect of saline…”
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SHock-INduced Endotheliopathy (SHINE): A mechanistic justification for viscoelastography-guided resuscitation of traumatic and non-traumatic shock by Bunch, Connor M, Chang, Eric, Moore, Ernest E, Moore, Hunter B, Kwaan, Hau C, Miller, Joseph B, Al-Fadhl, Mahmoud D, Thomas, Anthony V, Zackariya, Nuha, Patel, Shivani S, Zackariya, Sufyan, Haidar, Saadeddine, Patel, Bhavesh, McCurdy, Michael T, Thomas, Scott G, Zimmer, Donald, Fulkerson, Daniel, Kim, Paul Y, Walsh, Matthew R, Hake, Daniel, Kedar, Archana, Aboukhaled, Michael, Walsh, Mark M

“…Irrespective of the reason for hypoperfusion, hypocoagulable and/or hyperfibrinolytic hemostatic aberrancies afflict up to one-quarter of critically ill…”
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A principal component analysis of postinjury viscoelastic assays: Clotting factor depletion versus fibrinolysis by Chin, Theresa L., MD, Moore, Ernest E., MD, Moore, Hunter B., MD, Gonzalez, Eduardo, MD, Chapman, Michael P., MD, Stringham, John R., MD, Ramos, Christopher R., MD, Banerjee, Anirban, PhD, Sauaia, Angela, MD, PhD

“…Introduction The mechanisms driving trauma-induced coagulopathy (TIC) remain to be defined, and its therapy demands an orchestrated replacement of specific…”
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Viscoelastic Tissue Plasminogen Activator Challenge Predicts Massive Transfusion in 15 Minutes by Moore, Hunter B., MD, Moore, Ernest E., MD, FACS, Chapman, Michael P., MD, Huebner, Benjamin R., MD, Einersen, Peter M., MD, Oushy, Solimon, MD, Silliman, Christopher C., MD, PhD, Banerjee, Anirban, PhD, Sauaia, Angela, MD, PhD

“…Background Coagulopathy is associated with massive transfusion in trauma, yet most clinical scores to predict this end point do not incorporate coagulation…”
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Preoperative thrombelastography maximum amplitude predicts massive transfusion in liver transplantation by Lawson, Peter J., BA, Moore, Hunter B., MD, Moore, Ernest E., MD, Stettler, Gregory R., MD, Pshak, Thomas, MD, Kam, Igal, MD, Silliman, Christopher C., MD, PhD, Nydam, Trevor L., MD

“…Abstract Background Massive transfusion (MT) is frequently required during liver transplantation. Risk stratification of transplant patients at risk for MT is…”
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Salvage use of tissue plasminogen activator (tPA) in the setting of acute respiratory distress syndrome (ARDS) due to COVID-19 in the USA: a Markov decision analysis by Choudhury, Rashikh, Barrett, Christopher D, Moore, Hunter B, Moore, Ernest E, McIntyre, Robert C, Moore, Peter K, Talmor, Daniel S, Nydam, Trevor L, Yaffe, Michael B

“…COVID-19 threatens to quickly overwhelm our existing critical care infrastructure in the USA. Systemic tissue plasminogen activator (tPA) has been previously…”
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Plasma First in the Field for Postinjury Hemorrhagic Shock by Moore, Ernest E, Chin, Theresa L, Chapman, Michael C, Gonzalez, Eduardo, Moore, Hunter B, Silliman, Christopher C, Hansen, Kirk C, Sauaia, Angela, Banerjee, Anirban

“…ABSTRACTHemorrhage is the most preventable cause of death in civilian and military trauma, and despite tremendous advances in patient transport in the field,…”
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