Search Results - "Moore, Andrea R."

Minimal Essential Human Factor VIII Alterations Enhance Secretion and Gene Therapy Efficiency by Cao, Wenjing, Dong, Biao, Horling, Franziska, Firrman, Jenni A., Lengler, Johannes, Klugmann, Matthias, de la Rosa, Maurus, Wu, Wenman, Wang, Qizhao, Wei, Hongying, Moore, Andrea R., Roberts, Sean A., Booth, Carmen J., Hoellriegl, Werner, Li, Dong, Konkle, Barbara, Miao, Carol, Reipert, Birgit M., Scheiflinger, Friedrich, Rottensteiner, Hanspeter, Xiao, Weidong

“…One important limitation for achieving therapeutic expression of human factor VIII (FVIII) in hemophilia A gene therapy is inefficient secretion of the FVIII…”
Get full text

Vaccinia virus as a subhelper for AAV replication and packaging by Moore, Andrea R, Dong, Biao, Chen, Lingxia, Xiao, Weidong

“…Adeno-associated virus (AAV) has been widely used as a gene therapy vector to treat a variety of disorders. While these vectors are increasingly popular and…”
Get full text

A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy by Dong, Biao, Moore, Andrea R, Dai, Jihong, Roberts, Sean, Chu, Kirk, Kapranov, Philipp, Moss, Bernard, Xiao, Weidong

“…Scalable and efficient production of high-quality recombinant adeno-associated virus (rAAV) for gene therapy remains a challenge despite recent clinical…”
Get full text

Native molecular state of adeno-associated viral vectors revealed by single-molecule sequencing by Kapranov, Philipp, Chen, Lingxia, Dederich, Debra, Dong, Biao, He, Jie, Steinmann, Kathleen E, Moore, Andrea R, Thompson, John F, Milos, Patrice M, Xiao, Weidong

“…The single-stranded genome of adeno-associated viral (AAV) vectors is one of the key factors leading to slow-rising but long-term transgene expression…”
Get more information

Peroxisome Proliferator-Activated Receptor (PPAR) : Balance for Survival in Parasitic Infections by Chan, Marion M., Evans, Kyle W., Moore, Andrea R., Fong, Dunne

“…Parasitic infections induce a magnitude of host responses. At the opposite ends of the spectrum are those that ensure the host's needs to eliminate the…”
Get full text

Extrapulmonary Tuberculosis in Pregnancy Masquerading as a Degenerating Leiomyoma by Moore, Andrea R., Rogers, Francesca M., Dietrick, Donovan, Smith, Samuel

“…Tuberculosis (TB) is an increasingly common infectious complication of pregnancy. The diagnosis of extrapulmonary TB in pregnancy is hampered by many factors…”
Get full text

677. Stabilizing the rAAV Vector Genome Increases AAV Vector Transduction Efficiency by Pokiniewski, Katie A., Moore, Andrea R., Dong, Biao, Wang, Qizhao, Xiao, Weidong

Get full text

Scalable contaminant-free production of adeno-associated virus vectors utilizing cytoplasmic helper carrier by Dong, Biao, Moore, Andrea R, Dai, Jihong, Roberts, Sean, Chu, Kirk, Kapranov, Philipp, Moss, Bernard, Xiao, Weidong

“…Scalable and efficient production of high-quality recombinant adeno-associated virus (rAAV) for gene therapy remains a challenge despite recent clinical…”
Get full text