Search Results - "Moon‐Massat, Paula"

Brain oxygenation with a non‐vasoactive perfluorocarbon emulsion in a rat model of traumatic brain injury by Abutarboush, Rania, Mullah, Saad H., Saha, Biswajit K., Haque, Ashraful, Walker, Peter B., Aligbe, Chioma, Pappas, Georgina, Tran Ho, Lam Thuy Vi, Arnaud, Francoise G., Auker, Charles R., McCarron, Richard M., Scultetus, Anke H., Moon‐Massat, Paula

“…Objective The aim of this study was to assess, in two experiments, the safety and efficacy of the PFC emulsion Oxycyte as an oxygen therapeutic for TBI to test…”
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Effects of N-acetyl-L-cysteine and hyaluronic acid on HBOC-201-induced systemic and cerebral vasoconstriction in the rat by Abutarboush, Rania, Scultetus, Anke, Pappas, Georgina, Arnaud, Francoise, Auker, Charles, McCarron, Richard, Moon-Massat, Paula F

“…Hemoglobin-based oxygen carrier-201 (HBOC) was developed as a resuscitative fluid but concerns exist over potentially adverse vasoconstriction. This study…”
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Sanguinate's effect on pial arterioles in healthy rats and cerebral oxygen tension after controlled cortical impact by Mullah, Saad H., Abutarboush, Rania, Moon-Massat, Paula F., Saha, Biswajit K., Haque, Ashraful, Walker, Peter B., Auker, Charles R., Arnaud, Francoise G., McCarron, Richard M., Scultetus, Anke H.

“…Sanguinate, a polyethylene glycol-conjugated carboxyhemoglobin, was investigated for cerebral vasoactivity in healthy male Sprague-Dawley rats (Study 1) and…”
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Effects of perfluorocarbon dodecafluoropentane (NVX-108) on cerebral microvasculature in the healthy rat by Moon-Massat, Paula F, Abutarboush, Rania, Pappas, Georgina, Haque, Ashraful, Aligbe, Chioma, Arnaud, Francoise, Auker, Charles, McCarron, Richard, Scultetus, Anke

“…NVX-108, a dodecafluoropentane-based perfluorocarbon (PFC) emulsion, has therapeutic potential as an oxygen- carrying fluid for emergency medical treatment for…”
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Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran by Abutarboush, Rania, Saha, Biswajit K, Mullah, Saad H, Arnaud, Francoise G, Haque, Ashraful, Aligbe, Chioma, Pappas, Georgina, Auker, Charles R, McCarron, Richard M, Moon-Massat, Paula F, Scultetus, Anke H

“…Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death…”
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Dodecafluoropentane Emulsion (DDFPE) as a Resuscitation Fluid for Treatment of Hemorrhagic Shock and Traumatic Brain Injury: A Review by Graham, Kaitlin, Moon-Massat, Paula F, Unger, Evan C

“…ABSTRACTDodecafluoropentane emulsion (DDFPe) is a novel nanotechnology for oxygen delivery with therapeutic potential for hemorrhagic shock and/or traumatic…”
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When Blood Is Not an Option: Factors Affecting Survival After the Use of a Hemoglobin-Based Oxygen Carrier in 54 Patients with Life-Threatening Anemia by Mackenzie, Colin F., Moon-Massat, Paula F., Shander, Aryeh, Javidroozi, Mazyar, Greenburg, A. Gerson

“…In consenting Jehovah's Witness patients and others for whom blood is contraindicated or not available, hemoglobin-based oxygen carrier (HBOC)-201 may enable…”
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Hypobaria during long-range flight resulted in significantly increased histopathological evidence of lung and brain damage in a swine model by Scultetus, Anke H, Jefferson, Michelle A, Haque, Ashraful, Ho, Lam Thuy Vi Tran, Hazzard, Brittany, Saha, Biswajit K, Chun, Steve J, Auker, Charles R, Moon-Massat, Paula F, McCarron, Richard M, Malone, Debra L

“…Aeromedical evacuation to definitive care is standard in current military conflicts. However, there is minimal knowledge on the effects of hypobaria (HYPO) on…”
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Determination of methemoglobin and hemoglobin levels in small volume samples by Arnaud, Francoise, Higgins, Adam, McCarron, Richard, Moon-Massat, Paula F

“…Background/aims Hemoglobin-based oxygen carriers (HBOCs) have been previously studied as resuscitation fluids. Due to HBOCs specific molecular conformation,…”
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Effects of a hemoglobin-based oxygen carrier (HBOC-201) and derivatives with altered oxygen affinity and viscosity on systemic and microcirculatory variables in a top-load rat model by Song, Bjorn Kyungsuck, Nugent, William H., Moon-Massat, Paula F., Pittman, Roland N.

“…The effects of a polymerized bovine hemoglobin-based oxygen carrier (HBOC) and two derivatives on arteriolar vasoactivity and tissue oxygen tension were…”
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Normalization of hemoglobin-based oxygen carrier-201 induced vasoconstriction: targeting nitric oxide and endothelin by Taverne, Yannick J, de Wijs-Meijler, Daphne, Te Lintel Hekkert, Maaike, Moon-Massat, Paula F, Dubé, Gregory P, Duncker, Dirk J, Merkus, Daphne

“…Hemoglobin-based oxygen carrier (HBOC)-201 is a cell-free modified hemoglobin solution potentially facilitating oxygen uptake and delivery in cardiovascular…”
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In vitro alteration of hematological parameters and blood viscosity by the perfluorocarbon: Oxycyte by Arnaud, Françoise, Sanders, Katherine, Sieckmann, Donna, Moon-Massat, Paula

“…While perfluorocarbons (PFCs) may be useful in some clinical situations, previous studies have shown that interferences with chemistry analytes can occur with…”
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Hemoglobin measurements in samples containing hemoglobin-based oxygen carriers by Arnaud, Françoise, Sieckmann, Donna G, McCarron, Richard M, Moon-Massat, Paula F

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Fluid resuscitation of uncontrolled hemorrhage using a hemoglobin-based oxygen carrier: effect of traumatic brain injury by White, Nathan J, Wang, Xu, Bradbury, Nicole, Moon-Massat, Paula F, Freilich, Daniel, Auker, Charles, McCarron, Richard, Scultetus, Anke, Stern, Susan A

“…Animal models of combined traumatic brain injury (TBI) and hemorrhagic shock (HS) suggest a benefit of hemoglobin-based oxygen carrier (HBOC)-based…”
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Effects of oxypolygelatin and dextran 70 on hemostatic variables in dogs by Glowaski, Maria M, Moon-Massat, Paula F, Erb, Hollis N, Barr, Stephen C

“…To evaluate and compare coagulation variables following the administration of oxypolygelatin and dextran 70 to clinically healthy dogs. Randomized cross-over…”
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The effect HBOC-201 and sodium nitrite resuscitation after uncontrolled haemorrhagic shock in swine by Moon-Massat, Paula, Scultetus, Anke, Arnaud, Françoise, Brown, Ammon, Haque, Ashraful, Saha, Biswajit, Kim, Bobby, Sagini, Eileen, McGwin, Gerald, Auker, Charles, McCarron, Richard, Freilich, Daniel

“…Abstract Background Development of Haemoglobin-based oxygen carriers (HBOCs) as blood substitutes has reached an impasse due to clinically adverse outcomes…”
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Treatment of Swine Closed Head Injury with Perfluorocarbon NVX-428 by Arnaud, Francoise, Haque, Ashraful, Morris, MAJ Erin, Moon-Massat, Paula, Auker, Charles, Biswajit, Saha, Hazzard, Brittany, Tran Ho, Lam Thuy Vi, McCarron, Richard, Scultetus, Anke

“…Pre-hospital treatment of traumatic brain injury (TBI) with co-existing polytrauma is complicated by requirements for intravenous fluid volume vs. hypotensive…”
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Vital organ tissue oxygenation after serial normovolemic exchange transfusion with HBOC-201 in anesthetized swine by Muir, William W, Ilangovan, Govindasamy, Zweier, Jay L, Moon-Massat, Paula F, Rentko, Virginia T

“…This study determined the effects of serial, normovolemic, stepwise exchange transfusions with either 6% human serum albumin (HSA) or the hemoglobin-based…”
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Effects of top-loading a zero-link bovine hemoglobin, OxyVita, on systemic and microcirculatory variables by Song, Bjorn Kyungsuck, Nugent, William H, Moon-Massat, Paula F, Auker, Charles R, McCarron, Richard, Pittman, Roland N

“…This study was designed to test the effect of top-load infusions of increasing doses of two versions of the novel, high molecular weight hemoglobin-based…”
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Blood soluble polymers for enhancing near-vessel-wall RBC traffic in presence of hemoglobin based oxygen carrier by Marhefka, Joie N., Moon-Massat, Paula F., Dubé, Gregory P., Light, William R., Freilich, Daniel A., Russell, Alan J., Kameneva, Marina V.

“…The development and clinical applications of hemoglobin based oxygen carriers (HBOC) have been limited by vasoactivity, putatively related to the HBOC ability…”
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