Search Results - "Moon, Owen R."

Signaling via a CD28/CD40 chimeric costimulatory antigen receptor (CoStAR™), targeting folate receptor alpha, enhances T cell activity and augments tumor reactivity of tumor infiltrating lymphocytes by Kalaitsidou, Milena, Moon, Owen R, Sykorova, Martina, Bao, Leyuan, Qu, Yun, Sukumaran, Sujita, Valentine, Michael, Zhou, Xingliang, Pandey, Veethika, Foos, Kay, Medvedev, Sergey, Powell, Jr, Daniel J, Udyavar, Akshata, Gschweng, Eric, Rodriguez, Ruben, Dudley, Mark E, Hawkins, Robert E, Kueberuwa, Gray, Bridgeman, John S

“…Transfer of autologous tumor infiltrating lymphocytes (TIL) to patients with refractory melanoma has shown clinical efficacy in a number of trials. However,…”
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Alzheimer's disease‐associated P460L variant of EphA1 dysregulates receptor activity and blood‐brain barrier function by Owens, Helen A., Thorburn, Lauren E., Walsby, Elisabeth, Moon, Owen R., Rizkallah, Pierre, Sherwani, Subuhi, Tinsley, Caroline L., Rogers, Louise, Cerutti, Camilla, Ridley, Anne J., Williams, Julie, Knäuper, Vera, Ager, Ann

“…INTRODUCTION Genome‐wide association studies link susceptibility to late‐onset Alzheimer's disease (LOAD) with EphA1. Sequencing identified a non‐synonymous…”
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ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells by Mohammed, Rebar N., Wehenkel, Sophie C., Galkina, Elena V., Yates, Emma-Kate, Preece, Graham, Newman, Andrew, Watson, H. Angharad, Ohme, Julia, Bridgeman, John S., Durairaj, Ruban R. P., Moon, Owen R., Ladell, Kristin, Miners, Kelly L., Dolton, Garry, Troeberg, Linda, Kashiwagi, Masahide, Murphy, Gillian, Nagase, Hideaki, Price, David A., Matthews, R. James, Knäuper, Vera, Ager, Ann

“…L-selectin on T-cells is best known as an adhesion molecule that supports recruitment of blood-borne naïve and central memory cells into lymph nodes…”
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Antitumor activity of T cells expressing a novel anti-folate receptor alpha (FOLR1) costimulatory antigen receptor (CoStAR) in a human xenograft murine solid tumor model and implications for in-human studies by Moon, Owen R., Qu, Yun, King, Michael G., Mojadidi, Michelle, Chauvin-Fleurence, Cynthia, Yarka, Clare, Evans, Alicia, Zhou, Xingliang, Katopodi, Tania (Theoni), Udyavar, Akshata, Bridgeman, John S., Kueberuwa, Gray, Alvarez-Rodríguez, Rubén

“…2535 Background: ITIL-306 is an autologous tumor-infiltrating lymphocyte (TIL) therapy that integrates T-cell receptor (TCR)-specific antigen recognition…”
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