A retrospective analysis of the relationship between anti-cyclic citrullinated peptide antibody and interstitial lung disease in systemic sclerosis

Anti-cyclic citrullinated peptide antibody testing is used to diagnose rheumatoid arthritis and associated with interstitial lung disease in RA. Herein, we investigate the relationship between anti-CCP antibody and ILD in SSc. We performed a retrospective analysis at a tertiary medical center betwee...

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Bibliographic Details
Published in:	Scientific reports Vol. 12; no. 1; p. 19253
Main Authors:	Ha, Jang Woo, Hong, Yoo Jin, Cha, Hyun Jin, Moon, Jeonghun Daniel, Pyo, Jung Yoon, Lee, Sang-Won, Park, Yong-Beom, Park, Chul Hwan, Song, Jason Jungsik
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10-11-2022 Nature Publishing Group Nature Portfolio
Subjects:	631/250 692/4023 Anti-Citrullinated Protein Antibodies Antibodies Autoantibodies Autoimmune diseases Citrulline Dermatomyositis Humanities and Social Sciences Humans Lung diseases Lung Diseases, Interstitial - etiology Lupus Erythematosus, Systemic - epidemiology Medical records multidisciplinary Patients Peptides Peptides, Cyclic Polymyositis Retrospective Studies Rheumatoid arthritis Rheumatoid Factor Science Science (multidisciplinary) Scleroderma Scleroderma, Systemic - diagnosis Systemic lupus erythematosus Systemic sclerosis
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Summary:	Anti-cyclic citrullinated peptide antibody testing is used to diagnose rheumatoid arthritis and associated with interstitial lung disease in RA. Herein, we investigate the relationship between anti-CCP antibody and ILD in SSc. We performed a retrospective analysis at a tertiary medical center between 2005 and 2019. Patients with SSc, systemic lupus erythematosus, and polymyositis/dermatomyositis (PM/DM) were evaluated for anti-CCP antibody and ILD. Additionally, medical records of SSc patients with ILD were reviewed. SSc patients had the highest anti-CCP antibody positivity rate compared to those with SLE and PM/DM. The incidence of ILD was higher in SSc patients with anti-CCP antibody than in those without. The usual interstitial pneumonia (UIP) incidence was higher in the anti-CCP antibody-positive group than in the anti-CCP antibody-negative group. The DLCO was lower in the anti-CCP antibody-positive group than in the anti-CCP antibody-negative group. On multivariable analysis, factors associated with SSc-ILD were anti-CCP antibody or rheumatoid factor (β coefficient, 2.652 [95% CI 1.472 to 4.776]) and anti-Scl70 antibody (β coefficient, 4.011 [95% CI 2.142 to 7.508]). Anti-CCP antibody may be associated with a higher incidence of ILD in SSc. SSc patients with anti-CCP antibody may have more UIP pattern and lower DLCO. Trial Registration Retrospectively registered.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-23180-2