Search Results - "Moon, Jadie"

Scavengers in islets fuel diabetic autoimmunity by Moon, Jadie Y, Gallagher, Katherine A

“…Autoreactive lymphocytes that infiltrate the pancreatic islet environment and target β cells are primary drivers of type 1 diabetes. In this issue of Immunity,…”
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Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair by Audu, Christopher O., Melvin, William J., Joshi, Amrita D., Wolf, Sonya J., Moon, Jadie Y., Davis, Frank M., Barrett, Emily C., Mangum, Kevin D., Deng, Hongping, Xing, Xianying, Wasikowski, Rachel, Tsoi, Lam C., Sharma, Sriganesh B., Bauer, Tyler M., Shadiow, James, Corriere, Matthew A., Obi, Andrea T., Kunkel, Steven L., Levi, Benjamin, Moore, Bethany B., Gudjonsson, Johann E., Smith, Andrew M., Gallagher, Katherine A.

“…Macrophage plasticity is critical for normal tissue repair following injury. In pathologic states such as diabetes, macrophage plasticity is impaired, and…”
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Diabetic Wound Keratinocytes Induce Macrophage JMJD3-Mediated Nlrp3 Expression via IL-1R Signaling by Wolf, Sonya J, Audu, Christopher O, Moon, Jadie Y, Joshi, Amrita D, Melvin, William J, Barrett, Emily C, Mangum, Kevin, de Jimenez, Gabriela Saldana, Rocco, Sabrina, Buckley, Sam, Ahmed, Zara, Wasikowski, Rachael, Kahlenberg, J Michelle, Tsoi, Lam C, Gudjonsson, Johann E, Gallagher, Katherine A

“…Macrophage (Mφ) plasticity is critical for normal wound repair; however, in type 2 diabetic wounds, Mφs persist in a low-grade inflammatory state that prevents…”
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Production efficiency of the bacterial non-ribosomal peptide indigoidine relies on the respiratory metabolic state in S. cerevisiae by Wehrs, Maren, Prahl, Jan-Philip, Moon, Jadie, Li, Yuchen, Tanjore, Deepti, Keasling, Jay D, Pray, Todd, Mukhopadhyay, Aindrila

“…Beyond pathway engineering, the metabolic state of the production host is critical in maintaining the efficiency of cellular production. The biotechnologically…”
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Investigation of Bar-seq as a method to study population dynamics of Saccharomyces cerevisiae deletion library during bioreactor cultivation by Wehrs, Maren, Thompson, Mitchell G, Banerjee, Deepanwita, Prahl, Jan-Philip, Morella, Norma M, Barcelos, Carolina A, Moon, Jadie, Costello, Zak, Keasling, Jay D, Shih, Patrick M, Tanjore, Deepti, Mukhopadhyay, Aindrila

“…Abstract Background Despite the latest advancements in metabolic engineering for genome editing and characterization of host performance, the successful…”
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Correction to: Production efficiency of the bacterial non-ribosomal peptide indigoidine relies on the respiratory metabolic state in S. cerevisiae by Wehrs, Maren, Prahl, Jan-Philip, Moon, Jadie, Li, Yuchen, Tanjore, Deepti, Keasling, Jay D, Pray, Todd, Mukhopadhyay, Aindrila

“…Following publication of the original article [1], the authors have noted that the standard curve in Additional file 1: Figure S7 is incorrect…”
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The Histone Demethylase JMJD3 Regulates Smooth Muscle Differentiation and Is Associated With Blood Pressure by Mangum, Kevin, Joshi, Amrita, Wolf, Sonya, Barrett, Emily, Moon, Jadie, Moore, Bethany, Obi, Andrea T., Davis, Frank, Gallagher, Katherine A.

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The STAT3/SETDB2 axis dictates NF-κB-mediated inflammation in macrophages during wound repair by Mangum, Kevin D, denDekker, Aaron, Li, Qinmengge, Tsoi, Lam C, Joshi, Amrita D, Melvin, William J, Wolf, Sonya J, Moon, Jadie Y, Audu, Christopher O, Shadiow, James, Obi, Andrea T, Wasikowski, Rachael, Barrett, Emily C, Bauer, Tyler M, Boyer, Kylie, Ahmed, Zara, Davis, Frank M, Gudjonsson, Johann, Gallagher, Katherine A

“…Macrophage transition from an inflammatory to reparative phenotype after tissue injury is controlled by epigenetic enzymes that regulate inflammatory gene…”
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The histone methyltransferase mixed-lineage-leukemia-1 drives T cell phenotype via notch signaling in diabetic tissue repair by Melvin, William J, Bauer, Tyler M, Magnum, Kevin D, Audu, Christopher O, Shadiow, James, Barrett, Emily, Joshi, Amrita, Moon, Jadie Y, Bogel, Rachel, Mazumder, Purba, Wolf, Sonya J, Kunkel, Steven, Gudjonsson, Johann E, Davis, Frank M, Gallagher, Katherine A

“…Immune cell mediated inflammation is important in normal tissue regeneration but can be pathologic in diabetic wounds. Limited literature exists on the role of…”
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Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells by Audu, Christopher O, Wolf, Sonya J, Joshi, Amrita D, Moon, Jadie Y, Melvin, William J, Sharma, Sriganesh B, Davis, Frank M, Obi, Andrea T, Wasikowski, Rachel, Tsoi, Lam C, Barrett, Emily C, Mangum, Kevin D, Bauer, Tyler M, Kunkel, Steven L, Moore, Beth B, Gallagher, Katherine A

“…Plasmacytoid dendritic cells (pDCs) are first responders to tissue injury, where they prime naive T cells. The role of pDCs in physiologic wound repair has…”
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29-OR: Diabetic Wound Keratinocytes Induce Macrophage JMJD3–Mediated Nlrp3 Expression by WOLF-FORTUNE, SONYA, MOON, JADIE, JOSHI, AMRITA, MAZUMDER, PURBA, BARRETT, EMILY, MANGUM, KEVIN D., GALLAGHER, KATHERINE

“…Macrophage (Mφ) plasticity is critical for normal wound repair; however, type 2 diabetic (T2D) wound Mφs display a delayed chronic inflammatory state that…”
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Abstract 158: The Histone Demethylase JMJD3 Regulates Smooth Muscle Differentiation And Is Associated With Blood Pressure by Mangum, Kevin, Joshi, Amrita, Wolf, Sonya, Barrett, Emily, Moon, Jadie, Moore, Bethany, Obi, Andrea T, Davis, Frank, Gallagher, Katherine A

“…Abstract only Hypertension is associated with significant morbidity and mortality in the United States, and despite its prevalence an unmet need exists for…”
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Abstract 2140: The Tgfb-Whsc1 Axis Drives Macrophage To Myofibroblast Transition During Wound Repair by Mangum, Kevin D, Bauer, Tyler, Joshi, Amrita, Melvin, William, Barrett, Emily, Wolf, Sonya, Moon, Jadie, Shadiow, James, Obi, Andrea T, Gudjonsson, Johann, Davis, Frank, Gallagher, Katherine A

“…Abstract only During the proliferative phase of tissue repair macrophages can transition to myofibroblasts, which promote wound contraction and closure. The…”
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Abstract 2141: An IL12/IL23 Positive Feedback Loop Modulates Smooth Muscle Differentiation Via Setd4 During Macrophage-mediated Inflammation by Mangum, Kevin D, Bauer, Tyler, Joshi, Amrita, Barrett, Emily, Wolf, Sonya, Moon, Jadie, Shadiow, James, Obi, Andrea T, Gudjonsson, Johann, Davis, Frank, Gallagher, Katherine A

“…Abstract only Diabetic patients have increased risk of vascular disease (e.g., atherosclerosis), which is driven by macrophage-mediated inflammation. In…”
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The Histone Demethylase JMJD3 Regulates Smooth Muscle Cell Phenotype during Macrophage-mediated Inflammation by Mangum, Kevin D., Bauer, Tyler, Joshi, Amrita, Wolf-Fortune, Sonya, Moon, Jadie, Li, Qinmengge, Gudjonsson, Johann, Obi, Andrea, Davis, Frank, Gallagher, Katherine

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IL-17A-mediated JMJD3 regulation of integrin alpha 3 gene expression alters migration of diabetic keratinocytes and impairs wound repair by Moon, Jadie Yoonjoo, Wolf, Sonya, Audu, Christopher, Melvin, William, Joshi, Amrita, Mangum, Kevin, Barrett, Emily, Davis, Frank, Mazumder, Purba, Rocco, Sabrina, Erturk, Ilkim, Gallagher, Katherine

“…Abstract Keratinocytes are key structural cells in cell migration during wound repair. Keratinocyte migration is dysfunctional in diabetes and results in…”
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Diabetic wound keratinocytes induce macrophage JMJD3-mediated Nlrp3 expression via IL1R signaling by Wolf, Sonya, Audu, Christopher, Moon, Jadie Y, Joshi, Amrita D, Melvin, William J, Barrett, Emily C, Mangum, Kevin D, Gallagher, Katherine A

“…Abstract Type 2 diabetic (T2D) wound Macrophages (Mϕs) display a delayed chronic inflammatory state that prevents the resolution of wound inflammation…”
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Diabetic wound macrophage IL6 drives fibroblast dysfunction via the histone methyltransferase, SETDB2 by Joshi, Amrita D, Barrett, Emily C, Mangum, Kevin D, Mazumder, Purba, Rocco, Sabrina, Erturk, Asuman, Kai, Rohan, Moon, Jadie Yoonjoo, Wolf, Sonya, Gallagher, Katherine

“…Abstract Interactions between innate immune cells and structural cells are vital to proper tissue repair and regeneration after injury. Under pathologic…”
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IL-17A-mediated JMJD3 regulation of Cxcl1 gene expression in diabetic keratinocytes increases neutrophil recruitment and impairs wound repair by Moon, Jadie, Wolf, Sonya, Audu, Chris, Melvin, William, Joshi, Amrita, Mangum, Kevin, Barrett, Emily, Bauer, Tyler, Shadiow, James, Mazumder, Purba, Rocco, Sabrina, Erturk, Ilkim, Saldana de Jimenez, Gabriela, Moore, Bethany, Davis, Frank, Obi, Andrea, Gallagher, Katherine

“…Abstract Diabetic keratinocytes display an overexpression of chemokines that contribute to prolonged inflammation and non-healing. Using sequencing, we…”
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The histone methyltransferase Whsc1 regulates TGFβ-driven macrophage to myofibroblast transition by Mangum, Kevin D, Joshi, Amrita D, Melvin, William J, Mazumder, Purba, Erturk, Asuman, Wolf, Sonya, Barrett, Emily C, Moon, Jadie Yoonjoo, Obi, Andrea, Kunkel, Steven L, Moore, Bethany B, Gallagher, Katherine

“…Abstract In normal wound healing, macrophages regulate early and late inflammation, allowing for resolution of tissue injury and subsequent healing. During…”
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