Search Results - "Moon, Anne M"

Discovery and characterization of anti-cancer peptides from a random peptide library by Puvvula, Pavan Kumar, Moon, Anne M

“…We performed a forward genetic screen to discover peptides that specifically target breast cancer cells using a Penetratin tagged, random 15mer peptide…”
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Novel Cell-Penetrating Peptides Derived From Scaffold-Attachment- Factor A Inhibits Cancer Cell Proliferation and Survival by Puvvula, Pavan Kumar, Moon, Anne M

“…Scaffold-attachment-factor A (SAFA) has important roles in many normal and pathologic cellular processes but the scope of its function in cancer cells is…”
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Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development by Zhang, Lu, Nomura-Kitabayashi, Aya, Sultana, Nishat, Cai, Weibin, Cai, Xiaoqiang, Moon, Anne M., Cai, Chen-Leng

“…The vertebrate heart develops from mesoderm and requires inductive signals secreted from early endoderm. During embryogenesis, Nkx2.5 acts as a key…”
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Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis by Frank, Deborah U., Carter, Kandis L., Thomas, Kirk R., Burr, R. Michael, Bakker, Martijn L., Coetzee, William A., Tristani-Firouzi, Martin, Bamshad, Michael J., Christoffels, Vincent M., Moon, Anne M.

“…TBX3 is critical for human development: mutations in TBX3 cause congenital anomalies in patients with ulnar-mammary syndrome. Data from mice and humans suggest…”
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Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex by Kumar P, Pavan, Emechebe, Uchenna, Smith, Richard, Franklin, Sarah, Moore, Barry, Yandell, Mark, Lessnick, Stephen L, Moon, Anne M

“…Cellular senescence is a crucial tumor suppressor mechanism. We discovered a CAPERα/TBX3 repressor complex required to prevent senescence in primary cells and…”
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Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling by Park, Eon Joo, Ogden, Lisa A, Talbot, Amy, Evans, Sylvia, Cai, Chen-Leng, Black, Brian L, Frank, Deborah U, Moon, Anne M

“…Fibroblast growth factor 8 (Fgf8) is a secreted signaling protein expressed in numerous temporospatial domains that are potentially relevant to cardiovascular…”
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TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome by Kumar P, Pavan, Franklin, Sarah, Emechebe, Uchenna, Hu, Hao, Moore, Barry, Lehman, Chris, Yandell, Mark, Moon, Anne M

“…TBX3 is a member of the T-box family of transcription factors with critical roles in development, oncogenesis, cell fate, and tissue homeostasis. TBX3…”
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TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration by Melzer, Michael Karl, Schirge, Silvia, Gout, Johann, Arnold, Frank, Srinivasan, Dharini, Burtscher, Ingo, Allgöwer, Chantal, Mulaw, Medhanie, Zengerling, Friedemann, Günes, Cagatay, Lickert, Heiko, Christoffels, Vincent M, Liebau, Stefan, Wagner, Martin, Seufferlein, Thomas, Bolenz, Christian, Moon, Anne M, Perkhofer, Lukas, Kleger, Alexander

“…The reactivation of genetic programs from early development is a common mechanism for injury-induced organ regeneration. T-box 3 (TBX3) is a member of the…”
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Role of Mesodermal FGF8 and FGF10 Overlaps in the Development of the Arterial Pole of the Heart and Pharyngeal Arch Arteries by Watanabe, Yusuke, Miyagawa-Tomita, Sachiko, Vincent, Stéphane D, Kelly, Robert G, Moon, Anne M, Buckingham, Margaret E

“…RATIONALE:The genes encoding fibroblast growth factor (FGF) 8 and 10 are expressed in the anterior part of the second heart field that constitutes a population…”
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An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart by Park, Eon Joo, Watanabe, Yusuke, Smyth, Graham, Miyagawa-Tomita, Sachiko, Meyers, Erik, Klingensmith, John, Camenisch, Todd, Buckingham, Margaret, Moon, Anne M

“…In order to understand how secreted signals regulate complex morphogenetic events, it is crucial to identify their cellular targets. By conditional…”
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Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm by Calmont, Amélie, Ivins, Sarah, Van Bueren, Kelly Lammerts, Papangeli, Irinna, Kyriakopoulou, Vanessa, Andrews, William D, Martin, James F, Moon, Anne M, Illingworth, Elizabeth A, Basson, M Albert, Scambler, Peter J

“…Elucidating the gene regulatory networks that govern pharyngeal arch artery (PAA) development is an important goal, as such knowledge can help to identify new…”
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Mouse TBX3 mutants suggest novel molecular mechanisms for Ulnar-mammary syndrome by Frank, Deborah U, Emechebe, Uchenna, Thomas, Kirk R, Moon, Anne M

“…The transcription factor TBX3 plays critical roles in development and TBX3 mutations in humans cause Ulnar-mammary syndrome. Efforts to understand how altered…”
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Essential Roles of Androgen Signaling in Wolffian Duct Stabilization and Epididymal Cell Differentiation by Murashima, Aki, Miyagawa, Shinichi, Ogino, Yukiko, Nishida-Fukuda, Hisayo, Araki, Kimi, Matsumoto, Takahiro, Kaneko, Takehito, Yoshinaga, Kazuya, Yamamura, Ken-ichi, Kurita, Takeshi, Kato, Shigeaki, Moon, Anne M, Yamada, Gen

“…Epithelial androgen receptor has few functions for epithelial cell survival but is essential for cell differentiation in the epididymis. The epididymis is a…”
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Myocardial wall stiffening in a mouse model of persistent truncus arteriosus by Buffinton, Christine Miller, Benjamin, Alyssa K, Firment, Ashley N, Moon, Anne M

“…Genetic and epigenetic programs regulate dramatic structural changes during cardiac morphogenesis. Concurrent biomechanical forces within the heart created by…”
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Development of a subset of forelimb muscles and their attachment sites requires the ulnar-mammary syndrome gene Tbx3 by Colasanto, Mary P, Eyal, Shai, Mohassel, Payam, Bamshad, Michael, Bonnemann, Carsten G, Zelzer, Elazar, Moon, Anne M, Kardon, Gabrielle

“…In the vertebrate limb over 40 muscles are arranged in a precise pattern of attachment via muscle connective tissue and tendon to bone and provide an extensive…”
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T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number by Emechebe, Uchenna, Kumar P, Pavan, Rozenberg, Julian M, Moore, Bryn, Firment, Ashley, Mirshahi, Tooraj, Moon, Anne M

“…Crucial roles for T-box3 in development are evident by severe limb malformations and other birth defects caused by T-box3 mutations in humans. Mechanisms…”
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FGF8 initiates inner ear induction in chick and mouse by Ladher, Raj K, Wright, Tracy J, Moon, Anne M, Mansour, Suzanne L, Schoenwolf, Gary C

“…In both chick and mouse, the otic placode, the rudiment of the inner ear, is induced by at least two signals, one from the cephalic paraxial mesoderm and the…”
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System for tamoxifen‐inducible expression of cre‐recombinase from the Foxa2 locus in mice by Park, Eon Joo, Sun, Xiaoxia, Nichol, Peter, Saijoh, Yukio, Martin, James F., Moon, Anne M.

“…To study the roles of key transcription factor networks, growth factors, and signaling molecules in the endoderm, notochord, and floorplate, we developed an…”
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The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth by Boulet, Anne M., Moon, Anne M., Arenkiel, Benjamin R., Capecchi, Mario R.

“…Although numerous molecules required for limb bud formation have recently been identified, the molecular pathways that initiate this process and ensure that…”
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Fgf8 is required for outgrowth and patterning of the limbs by Capecchi, Mario R, Moon, Anne M

“…The expression pattern and activity of fibroblast growth factor-8 (FGF8) in experimental assays indicate that it has important roles in limb development, but…”
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