Search Results - "Mookhtiar, Kasim"

Recombinant irisin induces weight loss in high fat DIO mice through increase in energy consumption and thermogenesis by Niranjan, Sanjay B., Belwalkar, Shraddha Vijay, Tambe, Suhas, Venkataraman, Krishnan, Mookhtiar, Kasim A.

“…Irisin is known to be an important metabolic regulator of glucose and lipid metabolism. The aims of the present study are to assess the role of mouse Irisin in…”
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Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis by Geng, Jiefei, Ito, Yasushi, Shi, Linyu, Amin, Palak, Chu, Jiachen, Ouchida, Amanda Tomie, Mookhtiar, Adnan Kasim, Zhao, Heng, Xu, Daichao, Shan, Bing, Najafov, Ayaz, Gao, Guangping, Akira, Shizuo, Yuan, Junying

“…Stimulation of TNFR1 by TNFα can promote three distinct alternative mechanisms of cell death: necroptosis, RIPK1-independent and -dependent apoptosis. How…”
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RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS by Ito, Yasushi, Ofengeim, Dimitry, Najafov, Ayaz, Das, Sudeshna, Saberi, Shahram, Li, Ying, Hitomi, Junichi, Zhu, Hong, Chen, Hongbo, Mayo, Lior, Geng, Jiefei, Amin, Palak, DeWitt, Judy Park, Mookhtiar, Adnan Kasim, Florez, Marcus, Ouchida, Amanda Tomie, Fan, Jian-bing, Pasparakis, Manolis, Kelliher, Michelle A., Ravits, John, Yuan, Junying

“…Mutations in the optineurin (OPTN) gene have been implicated in both familial and sporadic amyotrophic lateral sclerosis (ALS). However, the role of this…”
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Design and synthesis of novel xanthine derivatives as potent and selective A2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases by Basu, Sujay, Barawkar, Dinesh A., Ramdas, Vidya, Patel, Meena, Waman, Yogesh, Panmand, Anil, Kumar, Santosh, Thorat, Sachin, Naykodi, Minakshi, Goswami, Arnab, Reddy, B. Srinivasa, Prasad, Vandna, Chaturvedi, Sandhya, Quraishi, Azfar, Menon, Suraj, Paliwal, Shalini, Kulkarni, Abhay, Karande, Vikas, Ghosh, Indraneel, Mustafa, Syed, De, Siddhartha, Jain, Vaibhav, Banerjee, Ena Ray, Rouduri, Sreekanth R., Palle, Venkata P., Chugh, Anita, Mookhtiar, Kasim A.

“…Adenosine induces bronchial hyperresponsiveness and inflammation in asthmatics through activation of A2B adenosine receptor (A2BAdoR). Selective antagonists…”
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Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model by Bhuniya, Debnath, Kharul, Rajendra K., Hajare, Atul, Shaikh, Nadim, Bhosale, Sandeep, Balwe, Sandip, Begum, Fouzia, De, Siddhartha, Athavankar, Sonalee, Joshi, Dhananjay, Madgula, Vamsi, Joshi, Kaushal, Raje, Amol A., Meru, Ashwinkumar V., Magdum, Amol, Mookhtiar, Kasim A., Barbhaiya, Rashmi

“…[Display omitted] •Novel scaffold as FAAH inhibitor with reversible mechanism of action.•Proof of MoA by recovery of active enzyme upon preincubation with…”
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Discovery and pharmacological evaluation of indole derivatives as potent and selective RORγt inverse agonist for multiple autoimmune conditions by Shaikh, Nadim S., Iyer, Jitesh P., Munot, Yogesh S., Mukhopadhyay, Partha P., Raje, Amol A., Nagaraj, Ranganayaki, Jamdar, Vijay, Gavhane, Ravindra, Lohote, Mahendra, Sherkar, Prasad, Bala, Madhu, Petla, Rajkanth, Meru, Ashwinkumar, Umrani, Dhananjay, Rouduri, Sreekanth, Joshi, Sachin, Reddy, Satyanarayan, Kandikere, Vishwottam, Bhuniya, Debnath, Kulkarni, Bheemashankar, Mookhtiar, Kasim A.

“…[Display omitted] •Identification of indole analogues as potent RORγt inverse agonists, SAR of around 44 compounds is presented.•Potent compounds were…”
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Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A2A Receptor Antagonists and Their Biological Evaluation by Basu, Sujay, Barawkar, Dinesh A, Thorat, Sachin, Shejul, Yogesh D, Patel, Meena, Naykodi, Minakshi, Jain, Vaibhav, Salve, Yogesh, Prasad, Vandna, Chaudhary, Sumit, Ghosh, Indraneel, Bhat, Ganesh, Quraishi, Azfar, Patil, Harish, Ansari, Shariq, Menon, Suraj, Unadkat, Vishal, Thakare, Rhishikesh, Seervi, Madhav S, Meru, Ashwinkumar V, De, Siddhartha, Bhamidipati, Ravi K, Rouduri, Sreekanth R, Palle, Venkata P, Chug, Anita, Mookhtiar, Kasim A

“…Our initial structure–activity relationship studies on 7-methoxy-4-morpholino-benzothiazole derivatives featured by aryloxy-2-methylpropanamide moieties at the…”
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Modifications of flexible nonyl chain and nucleobase head group of (+)-erythro-9-(2′s-hydroxy-3′s-nonyl)adenine [(+)-EHNA] as adenosine deaminase inhibitors by Kandalkar, Sachin R., Ramaiah, Parimi Atchuta, Joshi, Manoj, Wavhal, Atul, Waman, Yogesh, Raje, Amol A., Tambe, Ashwini, Ansari, Shariq, De, Siddhartha, Palle, Venkata P., Mookhtiar, Kasim A., Deshpande, Anil M., Barawkar, Dinesh A.

“…[Display omitted] A series of terminal nonyl chain and nucleobase modified analogues of (+)-EHNA (III) were synthesized and evaluated for their ability to…”
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Discovery of a potent and selective small molecule hGPR91 antagonist by Bhuniya, Debnath, Umrani, Dhananjay, Dave, Bhavesh, Salunke, Deepak, Kukreja, Gagan, Gundu, Jayasagar, Naykodi, Minakshi, Shaikh, Nadim S., Shitole, Prasad, Kurhade, Santosh, De, Siddhartha, Majumdar, Sreemita, Reddy, Srinivasa B., Tambe, Suhas, Shejul, Yogesh, Chugh, Anita, Palle, Venkata P., Mookhtiar, Kasim A., Cully, Doris, Vacca, Joseph, Chakravarty, Prasun K., Nargund, Ravi P., Wright, Samuel D., Graziano, Michael P., Singh, Sheo B., Roy, Sophie, Cai, Tian-Quan

“…GPR91, a 7TM G-Protein-Coupled Receptor, has been recently deorphanized with succinic acid as its endogenous ligand. Current literature indicates that GPR91…”
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257 Combination of adenosine antagonists A2AR (TT-10) and A2BR (TT-4) with checkpoint inhibitors demonstrate anti-tumor activity in CT-26 murine colon tumor allograft model by Pastore, Desa Rae, Kumar, Sushant, Schwartz, Brian, Mookhtiar, Kasim, Reddy, Vijay

“…BackgroundTT-10 and TT-4 are potent and selective antagonists of adenosine A2A receptor (A2AR) and A2B receptor (A2BR) respectively. Both agents are being…”
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Evaluation of separate role of intestine and liver in first pass metabolism of budesonide in rat by Raje, Amol A., Deshpande, Radni D., Pathade, Vishal V., Mahajan, Vallabh, Joshi, Kaushal, Tambe, Ashwini, Jinugu, Ramana, Madgula, Vamsi L. M., Gaur, Ashwani, Kandikere, Vishwottam, Patil, Chandragouda R., Mookhtiar, Kasim A.

“…1. Budesonide, a potent topical corticosteroid, reported to have low oral bioavailability in mice, rat, dog and human due to rapid first pass metabolism…”
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Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia by Deshpande, Anil M., Bhuniya, Debnath, De, Siddhartha, Dave, Bhavesh, Vyavahare, Vinod P., Kurhade, Santosh H., Kandalkar, Sachin R., Naik, Keshav P., Kobal, Balasaheb S., Kaduskar, Rahul D., Basu, Sujay, Jain, Vaibhav, Patil, Pratima, Chaturvedi Joshi, Sandhya, Bhat, Ganesh, Raje, Amol A., Reddy, Satyanarayana, Gundu, Jayasagar, Madgula, Vamsi, Tambe, Suhas, Shitole, Prasad, Umrani, Dhananjay, Chugh, Anita, Palle, Venkata P., Mookhtiar, Kasim A.

“…Glucokinase activators (GKAs) are among the emerging drug candidates for the treatment of type 2 diabetes (T2D). Despite effective blood glucose lowering in…”
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Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis by Thakkar, Mahesh, Bhuniya, Debnath, Kaduskar, Rahul, Mengawade, Tanaji, Naik, Keshav, Salunkhe, Videsh, Bhalerao, Amit, Kurhade, Santosh, Mavinahalli, Jagadeesh, Jain, Vaibhav, Petla, Rajkanth, Avaragolla, Satheesh, Ray, Swagatam, Rouduri, Sreekanth, Dhanave, Avinash, De, Siddhartha, Pathade, Vishal, Tambe, Ashwini, Raje, Amol A., Madgula, Vamsi, Joshi, Sachin, Nadeem, Ahmed, bala, Madhu, Umrani, Dhananjay, Hariharan, Narayanan, Kulkarni, Bheemashankar, Mookhtiar, Kasim A.

“…Anti-arthritic effect of 11 and 13 in mouse CIA model. [Display omitted] In a pursuit to identify reversible and selective BTK inhibitors, two series based on…”
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759 ADPORT-601 (TT-10–101): first-in-human study of adenosine 2A (A2A) and adenosine 2B (A2B) receptor antagonists in participants with selected advanced solid tumors by Subudhi, Sumit, Falchook, Gerald S, Salkeni, Mohamad A, El-Khoueiry, Anthony, Grewal, Jaspreet, Tester, William, Pachynski, Russell, Upadhaya, Samik, Saez Ibanez, Ana Rosa, Kumar, Sushant, Mookhtiar, Kasim, Stanton-Pastore, Desa Rae, Kramer, Robert, Fairchild, Justin, Walters, Ian, Fong, Lawrence

“…BackgroundDespite significant advances in immunotherapy, novel approaches to promoting immune response and overcoming immunosuppressive pathways are needed…”
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Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats by Ostrowski, Jacek, Kuhns, Joyce E, Lupisella, John A, Manfredi, Mark C, Beehler, Blake C, Krystek, Stanley R, Bi, Yingzhi, Sun, Chongqing, Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G, Fura, Aberra, An, Yongmi, Kish, Kevin F, Sack, John S, Mookhtiar, Kasim A, Grover, Gary J, Hamann, Lawrence G

“…A novel, highly potent, orally active, nonsteroidal tissue selective androgen receptor (AR) modulator (BMS-564929) has been identified, and this compound has…”
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Design and synthesis of novel xanthine derivatives as potent and selective A 2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases by Basu, Sujay, Barawkar, Dinesh A, Ramdas, Vidya, Patel, Meena, Waman, Yogesh, Panmand, Anil, Kumar, Santosh, Thorat, Sachin, Naykodi, Minakshi, Goswami, Arnab, Reddy, B Srinivasa, Prasad, Vandna, Chaturvedi, Sandhya, Quraishi, Azfar, Menon, Suraj, Paliwal, Shalini, Kulkarni, Abhay, Karande, Vikas, Ghosh, Indraneel, Mustafa, Syed, De, Siddhartha, Jain, Vaibhav, Banerjee, Ena Ray, Rouduri, Sreekanth R, Palle, Venkata P, Chugh, Anita, Mookhtiar, Kasim A

“…Adenosine induces bronchial hyperresponsiveness and inflammation in asthmatics through activation of A adenosine receptor (A AdoR). Selective antagonists have…”
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Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A 1 receptor antagonists and their biological evaluation by Koul, Summon, Ramdas, Vidya, Barawkar, Dinesh A, Waman, Yogesh B, Prasad, Neela, Madadi, Santosh Kumar, Shejul, Yogesh D, Bonagiri, Rajesh, Basu, Sujay, Menon, Suraj, Reddy, Srinivasa B, Chaturvedi, Sandhya, Chennamaneni, Srinivas Rao, Bedse, Gaurav, Thakare, Rhishikesh, Gundu, Jayasagar, Chaudhary, Sumit, De, Siddhartha, Meru, Ashwinkumar V, Palle, Venkata, Chugh, Anita, Mookhtiar, Kasim A

“…Multipronged approach was used to synthesize a library of diverse C-8 cyclopentyl hypoxanthine analogs from a common intermediate III. Several potent and…”
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Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A1 receptor antagonists and their biological evaluation by Koul, Summon, Ramdas, Vidya, Barawkar, Dinesh A., Waman, Yogesh B., Prasad, Neela, Madadi, Santosh Kumar, Shejul, Yogesh D., Bonagiri, Rajesh, Basu, Sujay, Menon, Suraj, Reddy, Srinivasa B., Chaturvedi, Sandhya, Chennamaneni, Srinivas Rao, Bedse, Gaurav, Thakare, Rhishikesh, Gundu, Jayasagar, Chaudhary, Sumit, De, Siddhartha, Meru, Ashwinkumar V., Palle, Venkata, Chugh, Anita, Mookhtiar, Kasim A.

“…[Display omitted] Multipronged approach was used to synthesize a library of diverse C-8 cyclopentyl hypoxanthine analogs from a common intermediate III…”
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Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A 2A Receptor Antagonists and Their Biological Evaluation by Basu, Sujay, Barawkar, Dinesh A, Thorat, Sachin, Shejul, Yogesh D, Patel, Meena, Naykodi, Minakshi, Jain, Vaibhav, Salve, Yogesh, Prasad, Vandna, Chaudhary, Sumit, Ghosh, Indraneel, Bhat, Ganesh, Quraishi, Azfar, Patil, Harish, Ansari, Shariq, Menon, Suraj, Unadkat, Vishal, Thakare, Rhishikesh, Seervi, Madhav S, Meru, Ashwinkumar V, De, Siddhartha, Bhamidipati, Ravi K, Rouduri, Sreekanth R, Palle, Venkata P, Chug, Anita, Mookhtiar, Kasim A

“…Our initial structure-activity relationship studies on 7-methoxy-4-morpholino-benzothiazole derivatives featured by aryloxy-2-methylpropanamide moieties at the…”
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A2B adenosine receptor antagonists: Design, synthesis and biological evaluation of novel xanthine derivatives by Basu, Sujay, Barawkar, Dinesh A., Ramdas, Vidya, Waman, Yogesh, Patel, Meena, Panmand, Anil, Kumar, Santosh, Thorat, Sachin, Bonagiri, Rajesh, Jadhav, Dilip, Mukhopadhyay, Partha, Prasad, Vandna, Reddy, B. Srinivasa, Goswami, Arnab, Chaturvedi, Sandhya, Menon, Suraj, Quraishi, Azfar, Ghosh, Indraneel, Dusange, Sushant, Paliwal, Shalini, Kulkarni, Abhay, Karande, Vikas, Thakre, Rhishikesh, Bedse, Gaurav, Rouduri, Sreekanth, Gundu, Jayasagar, Palle, Venkata P., Chugh, Anita, Mookhtiar, Kasim A.

“…A2BAdoR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling. The receptor has been…”
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