Search Results - "Mook, Olaf R. F."

Clinicobiological characteristics and treatment efficacy of novel agents in chronic lymphocytic leukemia with IGLV3-21R110 by Hengeveld, Paul J., Ertem, Y. Emre, Dubois, Julie M. N., Mellink, Clemens H. M., van der Kevie-Kersemaekers, Anne-Marie, Evers, Ludo M., Heezen, Kim, Kolijn, P. Martijn, Mook, Olaf R. F., Motazacker, M. Mahdi, Nasserinejad, Kazem, Kersting, S., Westerweel, Peter E., Niemann, Carsten U., Kater, Arnon P., Langerak, Anton W., Levin, Mark-David

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TGFBR1 Variants Can Associate with Non-Syndromic Congenital Heart Disease without Aortopathy by Alaamery, Manal, Albesher, Nour, Alhabshan, Fahad, Barnett, Phil, Salim Kabbani, Mohamed, Chaikhouni, Farah, Ilgun, Aho, Mook, Olaf R. F., Alsaif, Hessa, Christoffels, Vincent M., van Tintelen, Peter, Wilde, Arthur A. M., Houweling, Arjan C., Massadeh, Salam, Postma, Alex V.

“…Background: Congenital heart diseases (CHD) are the most common congenital malformations in newborns and remain the leading cause of mortality among infants…”
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Changes in gene expression of granulocytes during in vivo granulocyte colony-stimulating factor/dexamethasone mobilization for transfusion purposes by Drewniak, Agata, van Raam, Bram J., Geissler, Judy, Tool, Anton T.J., Mook, Olaf R.F., van den Berg, Timo K., Baas, Frank, Kuijpers, Taco W.

“…The treatment of healthy donors with granulocyte colony-stimulating factor (G-CSF) and dexamethasone results in sufficient numbers of circulating granulocytes…”
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Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4'-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer by Fluiter, Kees, Mook, Olaf R F, Vreijling, Jeroen, Langkjaer, Niels, Højland, Torben, Wengel, Jesper, Baas, Frank

“…Stability against nucleases, affinity for the targeted mRNA and the ability to recruit RNase H are prerequisites for antisense oligonucleotide (AON)…”
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Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression by Naue, Jana, Hoefsloot, Huub C.J., Mook, Olaf R.F., Rijlaarsdam-Hoekstra, Laura, van der Zwalm, Marloes C.H., Henneman, Peter, Kloosterman, Ate D., Verschure, Pernette J.

“…•An epigenetic age prediction tool for blood was developed based on MPS, and the DNA methylation levels of 13 markers.•Random forest regression (RFR) was used…”
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Noninvasive magnetic resonance imaging of the development of individual colon cancer tumors in rat liver by Mook, Olaf R F, Jonker, Ard, Strang, Aart C, Veltien, Andor, Gambarota, Giulio, Frederiks, Wilma M, Heerschap, Arend, Van Noorden, Cornelis J F

“…Monitoring tumor development is essential for the understanding of mechanisms involved in tumor progression and to determine efficacy of therapy. One of the…”
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Targeted sequence capture and GS-FLX Titanium sequencing of 23 hypertrophic and dilated cardiomyopathy genes: implementation into diagnostics by Mook, Olaf R F, Haagmans, Martin A, Soucy, Jean-François, van de Meerakker, Judith B A, Baas, Frank, Jakobs, Marja E, Hofman, Nynke, Christiaans, Imke, Lekanne Deprez, Ronald H, Mannens, Marcel M A M

“…Genetic evaluation of cardiomyopathies poses a challenge. Multiple genes are involved but no clear genotype-phenotype correlations have been found so far. In…”
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The therapeutic potential of LNA-modified siRNAs: reduction of off-target effects by chemical modification of the siRNA sequence by Fluiter, Kees, Mook, Olaf R F, Baas, Frank

“…Post-transcriptional gene silencing mediated by double-stranded RNA represents an evolutionarily conserved cellular mechanism. Small dsRNAs, such as microRNAs…”
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A novel alpha-tropomyosin mutation associates with dilated and non-compaction cardiomyopathy and diminishes actin binding by van de Meerakker, Judith B.A., Christiaans, Imke, Barnett, Phil, Lekanne Deprez, Ronald H., Ilgun, Aho, Mook, Olaf R.F., Mannens, Marcel M.A.M., Lam, Jan, Wilde, Arthur A.M., Moorman, Antoon F.M., Postma, Alex V.

“…Background: Dilated cardiomyopathy (DCM) is characterized by idiopathic dilatation and systolic contractile dysfunction of the ventricle(s) leading to an…”
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Visualization of early events in tumor formation of eGFP-transfected rat colon cancer cells in liver by Mook, Olaf R.F., Van Marle, Jan, Vreeling-Sindelárová, Heleen, Jonges, Remmet, Frederiks, Wilma M., Van Noorden, Cornelis J.F.

“…Colon cancer preferentially metastasizes to the liver. To determine cellular backgrounds of this preference, we generated an enhanced green fluorescent protein…”
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The role of gelatinases in colorectal cancer progression and metastasis by Mook, Olaf R.F., Frederiks, Wilma M., Van Noorden, Cornelis J.F.

“…Various proteases are involved in cancer progression and metastasis. In particular, gelatinases, matrix metalloproteinase-2 (MMP-2) and MMP-9, have been…”
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ITGFBR1/I Variants Can Associate with Non-Syndromic Congenital Heart Disease without Aortopathy by Alaamery, Manal, Albesher, Nour, Alhabshan, Fahad, Barnett, Phil, Salim Kabbani, Mohamed, Chaikhouni, Farah, Ilgun, Aho, Mook, Olaf R. F, Alsaif, Hessa, Christoffels, Vincent M, van Tintelen, Peter, Wilde, Arthur A. M, Houweling, Arjan C, Massadeh, Salam, Postma, Alex V

“…Background: Congenital heart diseases (CHD) are the most common congenital malformations in newborns and remain the leading cause of mortality among infants…”
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Clinicobiological characteristics and treatment efficacy of novel agents in chronic lymphocytic leukemia with IGLV3-21 R110 by Hengeveld, Paul J, Ertem, Y Emre, Dubois, Julie M N, Mellink, Clemens H M, van der Kevie-Kersemaekers, Anne-Marie, Evers, Ludo M, Heezen, Kim, Kolijn, P Martijn, Mook, Olaf R F, Motazacker, M Mahdi, Nasserinejad, Kazem, Kersting, S, Westerweel, Peter E, Niemann, Carsten U, Kater, Arnon P, Langerak, Anton W, Levin, Mark-David

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Metabolic Mapping of Proteinase Activity with Emphasis on In Situ Zymography of Gelatinases: Review and Protocols by Frederiks, Wilma M, Mook, Olaf R.F

“…Proteases are essential for protein catabolism, regulation of a wide range of biological processes, and in the pathogenesis of many diseases. Several…”
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In Situ Localization of Gelatinolytic Activity in the Extracellular Matrix of Metastases of Colon Cancer in Rat Liver Using Quenched Fluorogenic DQ-gelatin by Mook, Olaf R.F, Van Overbeek, Claudia, Ackema, Eleonora G, Van Maldegem, Febe, Frederiks, Wilma M

“…Matrix metalloproteinases (MMPs) such as gelatinases are believed to play an important role in invasion and metastasis of cancer. In this study we investigated…”
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Reply by Mook, Olaf R. F., Frederiks, Wilma M., Van Noorden, Cornelis J. F.

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