Search Results - "Mooijaart, Simon P"

High-Sensitivity Cardiac Troponin Concentration and Risk of First-Ever Cardiovascular Outcomes in 154,052 Participants by Willeit, Peter, Welsh, Paul, Evans, Jonathan D.W., Tschiderer, Lena, Boachie, Charles, Jukema, J. Wouter, Ford, Ian, Trompet, Stella, Stott, David J., Kearney, Patricia M., Mooijaart, Simon P., Kiechl, Stefan, Di Angelantonio, Emanuele, Sattar, Naveed

“…High-sensitivity assays can quantify cardiac troponins I and T (hs-cTnI, hs-cTnT) in individuals with no clinically manifest myocardial injury. The goal of…”
Get full text

Functional and Cognitive Impairment, Frailty, and Adverse Health Outcomes in Older Patients Reaching ESRD-A Systematic Review by Kallenberg, Marije H, Kleinveld, Hilda A, Dekker, Friedo W, van Munster, Barbara C, Rabelink, Ton J, van Buren, Marjolijn, Mooijaart, Simon P

“…Older patients reaching ESRD have a higher risk of adverse health outcomes. We aimed to determine the association of functional and cognitive impairment and…”
Get full text

Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies by Rieben, Carole, Segna, Daniel, da Costa, Bruno R, Collet, Tinh-Hai, Chaker, Layal, Aubert, Carole E, Baumgartner, Christine, Almeida, Osvaldo P, Hogervorst, Eef, Trompet, Stella, Masaki, Kamal, Mooijaart, Simon P, Gussekloo, Jacobijn, Peeters, Robin P, Bauer, Douglas C, Aujesky, Drahomir, Rodondi, Nicolas

“…Context: Although both overt hyper- and hypothyroidism are known to lead to cognitive impairment, data on the association between subclinical thyroid…”
Get full text

Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies by Rostamian, Somayeh, le Cessie, Saskia, Marijt, Koen A, Jukema, J Wouter, Mooijaart, Simon P, van Buchem, Mark A, van Hall, Thorbald, Gussekloo, Jacobijn, Trompet, Stella

“…Disturbed cognitive function is associated with several causes of mortality; however, the association between cognitive function and the risk of cancer death…”
Get full text

Prevalence and risk factors of burden among caregivers of older emergency department patients by Zaalberg, Tessel, Barten, Dennis G., van Heugten, Caroline M., Klijnsma, Petra, Knarren, Lieve, Hiemstra, Ytje, Kurvers, Roel A. J., Lekx, Anita W., Mooijaart, Simon P., Janssen-Heijnen, Maryska

“…The number of older individuals that live independently at home is rising. These older individuals often rely on caregivers who have a similar age and health…”
Get full text

Subclinical Thyroid Dysfunction and the Risk of Heart Failure in Older Persons at High Cardiovascular Risk by Nanchen, David, Gussekloo, Jacobijn, Westendorp, Rudi G. J, Stott, David J, Jukema, J. Wouter, Trompet, Stella, Ford, Ian, Welsh, Paul, Sattar, Naveed, Macfarlane, Peter W, Mooijaart, Simon P, Rodondi, Nicolas, de Craen, Anton J. M, on behalf of the PROSPER Group

“…Context: Subclinical thyroid dysfunction is common in older people. However, its clinical importance is uncertain. Objective: Our objective was to determine…”
Get full text

Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals by Akintola, Abimbola A, Noordam, Raymond, Jansen, Steffy W, de Craen, Anton J, Ballieux, Bart E, Cobbaert, Christa M, Mooijaart, Simon P, Pijl, Hanno, Westendorp, Rudi G, van Heemst, Diana

“…The validity of continuous glucose monitoring (CGM) is well established in diabetic patients. CGM is also increasingly used for research purposes in…”
Get full text

External validity of randomized controlled trials in older adults, a systematic review by van Deudekom, Floor J, Postmus, Iris, van der Ham, Danielle J, Pothof, Alexander B, Broekhuizen, Karen, Blauw, Gerard J, Mooijaart, Simon P

“…To critically assess the external validity of randomized controlled trials (RCTs) it is important to know what older adults have been enrolled in the trials…”
Get full text

Characteristics of randomized controlled trials designed for elderly: a systematic review by Broekhuizen, Karen, Pothof, Axel, de Craen, Anton J M, Mooijaart, Simon P

“…To quantify the proportion of randomized controlled trials (RCTs) specifically designed for elderly, and to assess their characteristics, as compared to RCTs…”
Get full text

Resting heart rate, heart rate variability and functional decline in old age by Ogliari, Giulia, Mahinrad, Simin, Stott, David J, Jukema, J Wouter, Mooijaart, Simon P, Macfarlane, Peter W, Clark, Elaine N, Kearney, Patricia M, Westendorp, Rudi G J, de Craen, Anton J M, Sabayan, Behnam

“…Heart rate and heart rate variability, markers of cardiac autonomic function, have been linked with cardiovascular disease. We investigated whether heart rate…”
Get full text

Secondary phenotype analysis in ascertained family designs: application to the Leiden longevity study by Tissier, Renaud, Tsonaka, Roula, Mooijaart, Simon P., Slagboom, Eline, Houwing‐Duistermaat, Jeanine J.

“…The case‐control design is often used to test associations between the case‐control status and genetic variants. In addition to this primary phenotype, a…”
Get full text

The most commonly used disease severity scores are inappropriate for risk stratification of older emergency department sepsis patients: an observational multi-centre study by de Groot, Bas, Stolwijk, Frank, Warmerdam, Mats, Lucke, Jacinta A, Singh, Gurpreet K, Abbas, Mo, Mooijaart, Simon P, Ansems, Annemieke, Esteve Cuevas, Laura, Rijpsma, Douwe

“…Sepsis recognition in older emergency department (ED) patients is difficult due to atypical symptom presentation. We therefore investigated whether the…”
Get full text

Experiences with and attitudes towards geriatric screening among older emergency department patients: a qualitative study by Blomaard, Laura C, Olthof, Mareline, Meuleman, Yvette, de Groot, Bas, Gussekloo, Jacobijn, Mooijaart, Simon P

“…The patient perspective on the use of screening for high risks of adverse health outcomes in Emergency Department (ED) care is underexposed, although it is an…”
Get full text

Effects of a web-based intervention on physical activity and metabolism in older adults: randomized controlled trial by Wijsman, Carolien A, Westendorp, Rudi Gj, Verhagen, Evert Alm, Catt, Michael, Slagboom, P Eline, de Craen, Anton Jm, Broekhuizen, Karen, van Mechelen, Willem, van Heemst, Diana, van der Ouderaa, Frans, Mooijaart, Simon P

“…Lack of physical activity leads to detrimental changes in body composition and metabolism, functional decline, and increased risk of disease in old age. The…”
Get full text

Temporal changes in characteristics and external validity of randomized controlled trials in older people from 2012 to 2019 by van Eijk, Estelle, van der Spek, Yanna M, van Deudekom, Floor J A, van den Bos, Frederiek, Mooijaart, Simon P, Trompet, Stella

“…Older individuals are often underrepresented in clinical trials. In 2012 only 7% of RCT's specifically studied older people and their geriatric characteristics…”
Get full text

Effects of discontinuation of levothyroxine treatment in older adults: protocol for a self-controlled trial by Ravensberg, A Janneke, Poortvliet, Rosalinde K E, Du Puy, Robert S, Dekkers, Olaf M, Mooijaart, Simon P, Gussekloo, Jacobijn

“…BackgroundMany older persons use the thyroid hormone levothyroxine which is often continued for life. Scientifically, there is much uncertainty whether simple…”
Get full text

Perspectives and experiences of patients and healthcare professionals with geriatric assessment in chronic kidney disease: a qualitative study by Voorend, Carlijn G N, Berkhout-Byrne, Noeleen C, Meuleman, Yvette, Mooijaart, Simon P, Bos, Willem Jan W, van Buren, Marjolijn

“…Older patients with end-stage kidney disease (ESKD) often live with unidentified frailty and multimorbidity. Despite guideline recommendations, geriatric…”
Get full text

Vital signs and impaired cognition in older emergency department patients: The APOP study by Lucke, Jacinta A, de Gelder, Jelle, Blomaard, Laura C, Heringhaus, Christian, Alsma, Jelmer, Klein Nagelvoort Schuit, Stephanie C E, Brink, Anniek, Anten, Sander, Blauw, Gerard J, de Groot, Bas, Mooijaart, Simon P

“…Cognitive impairment is a frequent problem among older patients attending the Emergency Department (ED) and can be the result of pre-existing cognitive…”
Get full text

DOSAGE study: protocol for a phase III non-inferiority randomised trial investigating dose-reduced chemotherapy for advanced colorectal cancer in older patients by Baltussen, Joosje C, van den Bos, Frederiek, Slingerland, Marije, Binda, Trishika R R, Liefers, Gerrit-Jan, van den Hout, Wilbert B, Fiocco, Marta, Verschoor, Arjan J, Cloos-van Balen, Marissa, Holterhues, Cynthia, Houtsma, Danny, Jochems, Anouk, Spierings, Leontine E A M M, van Bodegom-Vos, Leti, Mooijaart, Simon P, Gelderblom, Hans, Speetjens, Frank M, de Glas, Nienke A, Portielje, Johanneke E A

“…IntroductionTreating older adults with chemotherapy remains a challenge, given their under-representation in clinical trials and the lack of robust treatment…”
Get full text

Assessment of the appropriateness of cardiovascular preventive medication in older people: using the RAND/UCLA Appropriateness Method by van der Ploeg, Milly A, Poortvliet, Rosalinde K E, Achterberg, Wilco P, Mooijaart, Simon P, Gussekloo, Jacobijn, Drewes, Yvonne M

“…In clinical practice and science, there is debate for which older adults the benefits of cardiovascular preventive medications (CPM) still outweigh the risks…”
Get full text