Search Results - "Mooers, SU"

Catch Force Links and the Low to High Force Transition of Myosin by Butler, Thomas M., Mooers, Susan U., Siegman, Marion J.

“…Catch is characterized by maintenance of force with very low energy utilization in some invertebrate muscles. Catch is regulated by phosphorylation of the…”
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Twitchin from molluscan catch muscle: primary structure and relationship between site-specific phosphorylation and mechanical function by Funabara, Daisuke, Watabe, Shugo, Mooers, Susan U, Narayan, Srinivasa, Dudas, Csilla, Hartshorne, David J, Siegman, Marion J, Butler, Thomas M

“…The phosphorylation state of the myosin thick filament-associated mini-titin, twitchin, regulates catch force maintenance in molluscan smooth muscle. The…”
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The Myosin Cross-Bridge Cycle and Its Control by Twitchin Phosphorylation in Catch Muscle by Butler, Thomas M., Narayan, Srinivasa R., Mooers, Susan U., Hartshorne, David J., Siegman, Marion J.

“…The anterior byssus retractor muscle of Mytilus edulis was used to characterize the myosin cross-bridge during catch, a state of tonic force maintenance with a…”
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Regulation of Catch Muscle by Twitchin Phosphorylation: Effects on Force, ATPase, and Shortening by Butler, Thomas M., Mooers, Susan U., Li, Chenqing, Narayan, Srinivasa, Siegman, Marion J.

“…Recent experiments on permeabilized anterior byssus retractor muscle (ABRM) of Mytilus edulis have shown that phosphorylation of twitchin releases catch force…”
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Phosphorylation of a high molecular weight (approximately 600 kDa) protein regulates catch in invertebrate smooth muscle by Siegman, M J, Mooers, S U, Li, C, Narayan, S, Trinkle-Mulcahy, L, Watabe, S, Hartshorne, D J, Butler, T M

“…A unique property of smooth muscle is its ability to maintain force with a very low expenditure of energy. This characteristic is highly expressed in molluscan…”
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Lack of endothelium-dependent relaxation in coronary resistance arteries of cholesterol-fed rabbits by Osborne, J A, Siegman, M J, Sedar, A W, Mooers, S U, Lefer, A M

“…The endothelium-dependent contractile responses of subepicardial coronary resistance arteries (286 +/- 18 microns ID, n = 22) from rabbits fed either a 0.5 or…”
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Cooperative activation of myosin by light chain phosphorylation in permeabilized smooth muscle by Vyas, T B, Mooers, S U, Narayan, S R, Witherell, J C, Siegman, M J, Butler, T M

“…The purpose of this study was to determine the quantitative relationship between the number of myosin molecules that increase their ATPase activity and the…”
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Hypertrophy of colonic smooth muscle: structural remodeling, chemical composition, and force output by Siegman, M J, Butler, T M, Mooers, S U, Trinkle-Mulcahy, L, Narayan, S, Stirewalt, W S, Starcher, B C

“…The cellular basis of adaptations occurring during the development of megacolon was studied with the lethal spotted mouse model. Age-dependent changes in the…”
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Cross-bridge cycling at rest and during activation. Turnover of myosin-bound ADP in permeabilized smooth muscle by VYAS, T. B, MOOERS, S. U, NARAYAN, S. R, SIEGMAN, M. J, BUTLER, T. M

“…Single turnover experiments were performed on myosin-bound ADP by measuring the time course of incorporation of [3H]ADP following rapid formation of [3H]ATP by…”
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Rapid turnover of myosin light chain phosphate during cross-bridge cycling in smooth muscle by Butler, T M, Narayan, S R, Mooers, S U, Siegman, M J

“…The rate of phosphatase-mediated dephosphorylation of the regulatory light chain of smooth muscle myosin was determined under nearly steady-state conditions in…”
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Comparison of the effects of 2,3-butanedione monoxime on force production, myosin light chain phosphorylation and chemical energy usage in intact and permeabilized smooth and skeletal muscles by Siegman, M J, Mooers, S U, Warren, T B, Warshaw, D M, Ikebe, M, Butler, T M

“…The primary goal of this study was to determine the utility of 2,3-butanedione monoxime as a tool for determining and separating the chemical energy usage…”
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Altered isoactin gene expression in the affected bowel segments of the lethal spotted mouse by Liddell, R A, Mooers, S U, Siegman, M J, McHugh, K M

“…Actin is a key contractile protein associated with the normal differentiation and function of gastrointestinal smooth muscle cells. Distinct changes in…”
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Slowing of cross-bridge cycling in smooth muscle without evidence of an internal load by Butler, T M, Siegman, M J, Mooers, S U

“…We have tested whether the slowing in velocity of shortening that occurs in mammalian smooth muscle under conditions of high force output and dephosphorylated…”
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Phosphatase inhibition with okadaic acid does not alter the relationship between force and myosin light chain phosphorylation in permeabilized smooth muscle by Siegman, M J, Butler, T M, Mooers, S U

“…The phosphatase inhibitor, okadaic acid, has been used to test the hypothesis that myosin light chain phosphatase activity plays a central role in latchbridge…”
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Myosin-product complex in the resting state and during relaxation of smooth muscle by Butler, T M, Siegman, M J, Mooers, S U, Narayan, S R

“…Previous findings suggested that in resting smooth muscle ADP is bound to myosin and that phosphorylation of the myosin, and its subsequent interaction with…”
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Myosin Light Chain Phosphorylation Does not Modulate Cross-Bridge Cycling Rate in Mouse Skeletal Muscle by Butler, Thomas M., Siegman, Marion J., Mooers, Susan U., Barsotti, Robert J.

“…An attempt was made to determine whether phosphorylation of the myosin light chain represents a thick filament-associated mechanism for modulating the rate of…”
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Cooperative mechanisms in the regulation of smooth muscle contraction by Siegman, M J, Butler, T M, Vyas, T, Mooers, S U, Narayan, S

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Chemical energy usage during shortening and work production in mammalian smooth muscle by Butler, T M, Siegman, M J, Mooers, S U

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Chemical energetics of force development, force maintenance, and relaxation in mammalian smooth muscle [Rabbits] by Siegman, M J, Butler, T M, Mooers, S U, Davies, R E

“…High-energy phosphate utilization (delta approximately P) associated with force development, force maintenance, and relaxation has been determined during…”
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Chemical energy usage during stimulation and stretch of mammalian smooth muscle by BUTLER, T. M, SIEGMAN, M. J, MOOERS, S. V

“…High energy phosphate usage was measured in the rabbit taenia coli subjected to stimulation and stretch (0.12 Lo/min) and was compared to that observed…”
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