Search Results - "Moody, Tania"
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ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages
Published in Bone (New York, N.Y.) (01-12-2021)“…Macrophages play crucial roles in many human disease processes. However, obtaining large numbers of primary cells for study is often difficult. We describe 2D…”
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NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification
Published in JCI insight (15-11-2018)“…Inflammation helps regulate normal growth and tissue repair. Although bone morphogenetic proteins (BMPs) and inflammation are known contributors to abnormal…”
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Modeling the ACVR1R206H mutation in human skeletal muscle stem cells
Published in eLife (10-11-2021)“…Abnormalities in skeletal muscle repair can lead to poor function and complications such as scarring or heterotopic ossification (HO). Here, we use…”
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Modeling the ACVR1.sup.R206H mutation in human skeletal muscle stem cells
Published in eLife (10-11-2021)“…Abnormalities in skeletal muscle repair can lead to poor function and complications such as scarring or heterotopic ossification (HO). Here, we use…”
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Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole‐Exome Sequencing in a Patient with Delayed‐Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H‐Specific Human Cellular and Zebrafish Models
Published in Journal of bone and mineral research (01-11-2022)“…ABSTRACT Bone morphogenetic protein (BMP) signaling is critical in skeletal development. Overactivation can trigger heterotopic ossification (HO) as in…”
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Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone
Published in JBMR plus (01-05-2024)“…G protein-coupled receptors (GPCRs) mediate a wide spectrum of physiological functions, including the development, remodeling, and repair of the skeleton…”
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Global Wnt Inhibition With a Porcupine Inhibitor Decreases Established Trabecular Bone in a Mouse Model of Fibrous Dysplasia
Published in Journal of the Endocrine Society (03-05-2021)“…Abstract Background: G protein-coupled receptors (GPCRs) mediate a wide spectrum of physiological functions, including bone development and remodeling. Fibrous…”
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Modeling the ACVR1 R206H mutation in human skeletal muscle stem cells
Published in eLife (10-11-2021)“…Abnormalities in skeletal muscle repair can lead to poor function and complications such as scarring or heterotopic ossification (HO). Here, we use…”
Get full text
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SUN-368 Wnt Inhibition Decreases Trabecular Bone in a Mouse Model of Fibrous Dysplasia
Published in Journal of the Endocrine Society (08-05-2020)“…Abstract Background: G protein-coupled receptor (GPCR) signaling mediates a wide spectrum of physiological functions, including bone development and…”
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Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1 R206H -Specific Human Cellular and Zebrafish Models
Published in Journal of bone and mineral research (01-11-2022)“…Bone morphogenetic protein (BMP) signaling is critical in skeletal development. Overactivation can trigger heterotopic ossification (HO) as in fibrodysplasia…”
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MON-710 ACVR1 Activation in Primary and iPS-Derived Human Skeletal Muscle Stem Cells Impairs Myogenic Transcriptional Signature and Function
Published in Journal of the Endocrine Society (08-05-2020)“…Abstract Developing optimal strategies for skeletal muscle regeneration and repair requires a detailed understanding of how these processes are regulated. The…”
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ACVR1 R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages
Published in Bone (New York, N.Y.) (01-12-2021)“…Macrophages play crucial roles in many human disease processes. However, obtaining large numbers of primary cells for study is often difficult. We describe 2D…”
Get full text
Journal Article