Search Results - "Moody, Claire M."

Discovery and structure–activity relationships of novel sulfonamides as potent PTP1B inhibitors by Holmes, Christopher P., Li, Xianfeng, Pan, Yijun, Xu, Caiding, Bhandari, Ashok, Moody, Claire M., Miguel, Joy A., Ferla, Steven W., De Francisco, M. Nuria, Frederick, Brian T., Zhou, Siqun, Macher, Natalie, Jang, Larry, Irvine, Jennifer D., Grove, J. Russell

“…A series of novel sulfonamides containing a single DFMP group were discovered to be potent inhibitors of PTP1B. Investigation of SAR led to the identification…”
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PTP1B inhibitors: Synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold by Holmes, Christopher P., Li, Xianfeng, Pan, Yijun, Xu, Caiding, Bhandari, Ashok, Moody, Claire M., Miguel, Joy A., Ferla, Steven W., De Francisco, M. Nuria, Frederick, Brian T., Zhou, Siqun, Macher, Natalie, Jang, Larry, Irvine, Jennifer D., Grove, J. Russell

“…We have synthesized and evaluated a series of triaryl sulfonamide-based PTP1B inhibitors in which a difluoro-methylenephosphonate group of a potent lead has…”
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The biosynthesis of the Streptomyces antibiotic bicyclomycin by Bradley, Emma L, Herbert, Richard B, Lawrie, Kenneth W.M, Khan, Jeffrey A, Moody, Claire M, Young, Douglas W

“…Bicyclomycin 5 is biosynthesized in Streptomyces sapporonensis from L-leucine 2 and L-isoleucine 1 by way of the naturally occurring diketopiperazine 3 and…”
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19F Nuclear Magnetic Resonance Chemical Shifts of Fluorine Containing Aliphatic Amino Acids in Proteins:  Studies on Lactobacillus casei Dihydrofolate Reductase Containing (2S,4S)-5-Fluoroleucine by Feeney, James, McCormick, John E, Bauer, Christopher J, Birdsall, Berry, Moody, Claire M, Starkmann, Bernard A, Young, Douglas W, Francis, Peter, Havlin, Robert H, Arnold, William D, Oldfield, Eric

“…We have prepared Lactobacillus casei dihydrofolate reductase containing biosynthetically incorporated (2S,4S)-5-fluoroleucine ([5-F]-Leu DHFR) and have…”
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Design, synthesis and structure of a zinc finger with an artificial β-turn by Viles, John H., Patel, Sunil U., Mitchell, John B.O., Moody, Claire M., Justice, David E., Uppenbrink, Julia, Doyle, Paul M., Harris, C.John, Sadler, Peter J., Thornton, Janet M.

“…We have incorporated a bicyclic β-turn mimetic (BTD; β-turn dipeptide) into a zinc finger, creating a zinc finger with an artificial β-turn. The designed…”
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Towards meeting the paracelsus challenge: The design, synthesis, and characterization of paracelsin-43, an α-helical protein with over 50% sequence identity to an all-β protein by Jones, David T., Moody, Claire M., Uppenbrink, Julia, Viles, John H., Doyle, Paul M., Harris, C. John, Pearl, Laurence H., Sadler, Peter J., Thornton, Janet M.

“…In response to the Paracelsus Challenge (Rose and Creamer, Proteins, 19:1–3, 1994), we present here the design, synthesis, and characterization of a helical…”
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19 F Nuclear Magnetic Resonance Chemical Shifts of Fluorine Containing Aliphatic Amino Acids in Proteins:  Studies on Lactobacillus casei Dihydrofolate Reductase Containing (2 S ,4 S )-5-Fluoroleucine by Feeney, James, McCormick, John E., Bauer, Christopher J., Birdsall, Berry, Moody, Claire M., Starkmann, Bernard A., Young, Douglas W., Francis, Peter, Havlin, Robert H., Arnold, William D., Oldfield, Eric

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Solution structure of a biologically active cyclic LDV peptide analogue containing a type II' beta-turn mimetic by Doyle, P M, Harris, J C, Moody, C M, Sadler, P J, Sims, M, Thornton, J M, Uppenbrink, J, Viles, J H

“…The solution structure of cyclo-[Gly-Leu-Asp-Val-BTD] (BTD = beta-turn dipeptide) has been determined by two-dimensional 1H-NMR (nuclear magnetic resonance)…”
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