Search Results - "Moody, Branch"

Efficient and precise single-cell reference atlas mapping with Symphony by Kang, Joyce B., Nathan, Aparna, Weinand, Kathryn, Zhang, Fan, Millard, Nghia, Rumker, Laurie, Moody, D. Branch, Korsunsky, Ilya, Raychaudhuri, Soumya

“…Recent advances in single-cell technologies and integration algorithms make it possible to construct comprehensive reference atlases encompassing many donors,…”
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CD1 displays its own negative regulators by Shahine, Adam, Van Rhijn, Ildiko, Rossjohn, Jamie, Moody, D. Branch

“…After two decades of the study of lipid antigens that activate CD1-restricted T cells, new studies show how autoreactive αβ T-cell receptors (TCRs) can…”
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Lipid and small-molecule display by CD1 and MR1 by Van Rhijn, Ildiko, Godfrey, Dale I., Rossjohn, Jamie, Moody, D. Branch

“…Key Points Whereas peptide–MHC complexes are the usual model for technology development focused on T cells, the discovery of lipids and non-lipid small…”
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Protein kinases PknA and PknB independently and coordinately regulate essential Mycobacterium tuberculosis physiologies and antimicrobial susceptibility by Zeng, Jumei, Platig, John, Cheng, Tan-Yun, Ahmed, Saima, Skaf, Yara, Potluri, Lakshmi-Prasad, Schwartz, Daniel, Steen, Hanno, Moody, D Branch, Husson, Robert N

“…The Mycobacterium tuberculosis Ser/Thr protein kinases PknA and PknB are essential for growth and have been proposed as possible drug targets. We used a…”
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CD1a and bound lipids drive T‐cell responses in human skin disease by Ogg, Graham S., Rossjohn, Jamie, Clark, Rachael A., Moody, D. Branch

“…In addition to serving as the main physical barrier with the outside world, human skin is abundantly infiltrated with resident αβ T cells that respond…”
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Periprotein lipidomes of Saccharomyces cerevisiae provide a flexible environment for conformational changes of membrane proteins by van 't Klooster, Joury S, Cheng, Tan-Yun, Sikkema, Hendrik R, Jeucken, Aike, Moody, Branch, Poolman, Bert

“…Yeast tolerates a low pH and high solvent concentrations. The permeability of the plasma membrane (PM) for small molecules is low and lateral diffusion of…”
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Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians by Luo, Yang, Suliman, Sara, Asgari, Samira, Amariuta, Tiffany, Baglaenko, Yuriy, Martínez-Bonet, Marta, Ishigaki, Kazuyoshi, Gutierrez-Arcelus, Maria, Calderon, Roger, Lecca, Leonid, León, Segundo R., Jimenez, Judith, Yataco, Rosa, Contreras, Carmen, Galea, Jerome T., Becerra, Mercedes, Nejentsev, Sergey, Nigrovic, Peter A., Moody, D. Branch, Murray, Megan B., Raychaudhuri, Soumya

“…Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis , 5–15% will develop active tuberculosis (TB). Approximately half will progress to…”
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Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease by Nathan, Aparna, Beynor, Jessica I., Baglaenko, Yuriy, Suliman, Sara, Ishigaki, Kazuyoshi, Asgari, Samira, Huang, Chuan-Chin, Luo, Yang, Zhang, Zibiao, Lopez, Kattya, Lindestam Arlehamn, Cecilia S., Ernst, Joel D., Jimenez, Judith, Calderón, Roger I., Lecca, Leonid, Van Rhijn, Ildiko, Moody, D. Branch, Murray, Megan B., Raychaudhuri, Soumya

“…Multimodal T cell profiling can enable more precise characterization of elusive cell states underlying disease. Here, we integrated single-cell RNA and surface…”
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COPI acts in both vesicular and tubular transport by Luini, Alberto, Hsu, Victor W, Yang, Jia-Shu, Valente, Carmen, Polishchuk, Roman S, Turacchio, Gabriele, Layre, Emilie, Branch Moody, D, Leslie, Christina C, Gelb, Michael H, Brown, William J, Corda, Daniela

“…Intracellular transport occurs through two general types of carrier, either vesicles or tubules. Coat proteins act as the core machinery that initiates vesicle…”
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Establishment of CD1b-restricted immunity to lipid antigens in the pulmonary response to Mycobacterium tuberculosis infection by Harris, Macallister C., Gary, Hadley E., Cooper, Sarah K., Ackart, David F., DiLisio, James E., Basaraba, Randall J., Cheng, Tan-Yun, van Rhijn, Ildiko, Branch Moody, D., Podell, Brendan K.

“…CD1 is an antigen-presenting glycoprotein homologous to MHC I; however, CD1 proteins present lipid rather than peptide antigens. CD1 proteins are well…”
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A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis by Zhang, Lei, Kent, James E., Whitaker, Meredith, Young, David C., Herrmann, Dominik, Aleshin, Alexander E., Ko, Ying-Hui, Cingolani, Gino, Saad, Jamil S., Moody, D. Branch, Marassi, Francesca M., Ehrt, Sabine, Niederweis, Michael

“…Iron is essential for growth of Mycobacterium tuberculosis , the causative agent of tuberculosis. To acquire iron from the host, M. tuberculosis uses the…”
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The Mycobacterium tuberculosis regulatory network and hypoxia by Galagan, James E., Minch, Kyle, Peterson, Matthew, Lyubetskaya, Anna, Azizi, Elham, Sweet, Linsday, Gomes, Antonio, Rustad, Tige, Dolganov, Gregory, Glotova, Irina, Abeel, Thomas, Mahwinney, Chris, Kennedy, Adam D., Allard, René, Brabant, William, Krueger, Andrew, Jaini, Suma, Honda, Brent, Yu, Wen-Han, Hickey, Mark J., Zucker, Jeremy, Garay, Christopher, Weiner, Brian, Sisk, Peter, Stolte, Christian, Winkler, Jessica K., Van de Peer, Yves, Iazzetti, Paul, Camacho, Diogo, Dreyfuss, Jonathan, Liu, Yang, Dorhoi, Anca, Mollenkopf, Hans-Joachim, Drogaris, Paul, Lamontagne, Julie, Zhou, Yiyong, Piquenot, Julie, Park, Sang Tae, Raman, Sahadevan, Kaufmann, Stefan H. E., Mohney, Robert P., Chelsky, Daniel, Moody, D. Branch, Sherman, David R., Schoolnik, Gary K.

“…We have taken the first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq and combined this…”
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Mycobacterium tuberculosis releases an antacid that remodels phagosomes by Buter, Jeffrey, Cheng, Tan-Yun, Ghanem, Marwan, Grootemaat, Anita E., Raman, Sahadevan, Feng, Xinxin, Plantijn, Ashmir R., Ennis, Thomas, Wang, Joyce, Cotton, Rachel N., Layre, Emilie, Ramnarine, Alexandrea K., Mayfield, Jacob A., Young, David C., Jezek Martinot, Amanda, Siddiqi, Noman, Wakabayashi, Shoko, Botella, Helene, Calderon, Roger, Murray, Megan, Ehrt, Sabine, Snider, Barry B., Reed, Michael B., Oldfield, Eric, Tan, Shumin, Rubin, Eric J., Behr, Marcel A., van der Wel, Nicole N., Minnaard, Adriaan J., Moody, D. Branch

“…Mycobacterium tuberculosis ( Mtb ) is the world’s most deadly pathogen. Unlike less virulent mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an…”
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Lipidomic profiling of model organisms and the world's major pathogens by Layre, Emilie, Moody, D. Branch

“…Lipidomics is a subspecialty of metabolomics that focuses on water insoluble metabolites that form membrane barriers. Most lipidomic databases catalog lipids…”
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A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy by Madigan, Cressida A., Cambier, C.J., Kelly-Scumpia, Kindra M., Scumpia, Philip O., Cheng, Tan-Yun, Zailaa, Joseph, Bloom, Barry R., Moody, D. Branch, Smale, Stephen T., Sagasti, Alvaro, Modlin, Robert L., Ramakrishnan, Lalita

“…Mycobacterium leprae causes leprosy and is unique among mycobacterial diseases in producing peripheral neuropathy. This debilitating morbidity is attributed to…”
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Co-varying neighborhood analysis identifies cell populations associated with phenotypes of interest from single-cell transcriptomics by Reshef, Yakir A., Rumker, Laurie, Kang, Joyce B., Nathan, Aparna, Korsunsky, Ilya, Asgari, Samira, Murray, Megan B., Moody, D. Branch, Raychaudhuri, Soumya

“…As single-cell datasets grow in sample size, there is a critical need to characterize cell states that vary across samples and associate with sample…”
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History of tuberculosis disease is associated with genetic regulatory variation in Peruvians by Nieto-Caballero, Victor E, Reijneveld, Josephine F, Ruvalcaba, Angel, Innocenzi, Gabriel, Abeydeera, Nalin, Asgari, Samira, Lopez, Kattya, Iwany, Sarah K, Luo, Yang, Nathan, Aparna, Fernandez-Salinas, Daniela, Chiñas, Marcos, Huang, Chuan-Chin, Zhang, Zibiao, León, Segundo R, Calderon, Roger I, Lecca, Leonid, Budzik, Jonathan M, Murray, Megan, Van Rhijn, Ildiko, Raychaudhuri, Soumya, Moody, D Branch, Suliman, Sara, Gutierrez-Arcelus, Maria

“…A quarter of humanity is estimated to have been exposed to Mycobacterium tuberculosis (Mtb) with a 5-10% risk of developing tuberculosis (TB) disease…”
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Mincle is a long sought receptor for mycobacterial cord factor by Matsunaga, Isamu, Moody, D Branch

“…Mycobacterium tuberculosis is a leading killer worldwide, yet the adjuvancy of its cell wall has proven to be a valuable therapeutic tool for vaccination and…”
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Peripheral Blood Mucosal-Associated Invariant T Cells in Tuberculosis Patients and Healthy Mycobacterium tuberculosis-Exposed Controls by Suliman, Sara, Gela, Anele, Mendelsohn, Simon C, Iwany, Sarah K, Tamara, Kattya Lopez, Mabwe, Simbarashe, Bilek, Nicole, Darboe, Fatoumatta, Fisher, Michelle, Corbett, Alexandra J, Kjer-Nielsen, Lars, Eckle, Sidonia B G, Huang, Chuan-Chin, Zhang, Zibiao, Lewinsohn, David M, McCluskey, James, Rossjohn, Jamie, Hatherill, Mark, León, Segundo R, Calderon, Roger I, Lecca, Leonid, Murray, Megan, Scriba, Thomas J, Van Rhijn, Ildiko, Moody, D Branch

“…Abstract Background In human blood, mucosal-associated invariant T (MAIT) cells are abundant T cells that recognize antigens presented on non-polymorphic major…”
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Hepatitis B virus–induced lipid alterations contribute to natural killer T cell–dependent protective immunity by Zeissig, Sebastian, Murata, Kazumoto, Sweet, Lindsay, Publicover, Jean, Hu, Zongyi, Kaser, Arthur, Bosse, Esther, Iqbal, Jahangir, Hussain, M Mahmood, Balschun, Katharina, Röcken, Christoph, Arlt, Alexander, Günther, Rainer, Hampe, Jochen, Schreiber, Stefan, Baron, Jody L, Moody, D Branch, Liang, T Jake, Blumberg, Richard S

“…Hepatitis B virus (HBV) infection is known to be controlled by T and B cell responses, but the role of natural killer T (NKT) cells is less clear. Richard…”
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