Search Results - "Monzel, Anna S"

Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction by Monzel, Anna S., Enríquez, José Antonio, Picard, Martin

“…Mitochondria have cell-type specific phenotypes, perform dozens of interconnected functions and undergo dynamic and often reversible physiological…”
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Millifluidic culture improves human midbrain organoid vitality and differentiation by Berger, Emanuel, Magliaro, Chiara, Paczia, Nicole, Monzel, Anna S, Antony, Paul, Linster, Carole L, Bolognin, Silvia, Ahluwalia, Arti, Schwamborn, Jens C

“…Human midbrain-specific organoids (hMOs) serve as an experimental in vitro model for studying the pathogenesis of Parkinson's disease (PD). In hMOs,…”
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Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells by Monzel, Anna S., Smits, Lisa M., Hemmer, Kathrin, Hachi, Siham, Moreno, Edinson Lucumi, van Wuellen, Thea, Jarazo, Javier, Walter, Jonas, Brüggemann, Inga, Boussaad, Ibrahim, Berger, Emanuel, Fleming, Ronan M.T., Bolognin, Silvia, Schwamborn, Jens C.

“…Research on human brain development and neurological diseases is limited by the lack of advanced experimental in vitro models that truly recapitulate the…”
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Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice by Rosenberg, Ayelet M., Saggar, Manish, Monzel, Anna S., Devine, Jack, Rogu, Peter, Limoges, Aaron, Junker, Alex, Sandi, Carmen, Mosharov, Eugene V., Dumitriu, Dani, Anacker, Christoph, Picard, Martin

“…The brain and behavior are under energetic constraints, limited by mitochondrial energy transformation capacity. However, the mitochondria-behavior…”
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Modeling Parkinson’s disease in midbrain-like organoids by Smits, Lisa M., Reinhardt, Lydia, Reinhardt, Peter, Glatza, Michael, Monzel, Anna S., Stanslowsky, Nancy, Rosato-Siri, Marcelo D., Zanon, Alessandra, Antony, Paul M., Bellmann, Jessica, Nicklas, Sarah M., Hemmer, Kathrin, Qing, Xiaobing, Berger, Emanuel, Kalmbach, Norman, Ehrlich, Marc, Bolognin, Silvia, Hicks, Andrew A., Wegner, Florian, Sterneckert, Jared L., Schwamborn, Jens C.

“…Modeling Parkinson’s disease (PD) using advanced experimental in vitro models is a powerful tool to study disease mechanisms and to elucidate unexplored…”
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Machine learning-assisted neurotoxicity prediction in human midbrain organoids by Monzel, Anna S., Hemmer, Kathrin, Kaoma, Tony, Smits, Lisa M., Bolognin, Silvia, Lucarelli, Philippe, Rosety, Isabel, Zagare, Alise, Antony, Paul, Nickels, Sarah L., Krueger, Rejko, Azuaje, Francisco, Schwamborn, Jens C.

“…Brain organoids are highly complex multi-cellular tissue proxies, which have recently risen as novel tools to study neurodegenerative diseases such as…”
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Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality by Walter, Jonas, Bolognin, Silvia, Antony, Paul M.A., Nickels, Sarah L., Poovathingal, Suresh K., Salamanca, Luis, Magni, Stefano, Perfeito, Rita, Hoel, Fredrik, Qing, Xiaobing, Jarazo, Javier, Arias-Fuenzalida, Jonathan, Ignac, Tomasz, Monzel, Anna S., Gonzalez-Cano, Laura, Pereira de Almeida, Luis, Skupin, Alexander, Tronstad, Karl J., Schwamborn, Jens C.

“…Emerging evidence suggests that Parkinson's disease (PD), besides being an age-associated disorder, might also have a neurodevelopment component. Disruption of…”
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The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1 by Walter, Jonas, Bolognin, Silvia, Poovathingal, Suresh K., Magni, Stefano, Gérard, Deborah, Antony, Paul M.A., Nickels, Sarah L., Salamanca, Luis, Berger, Emanuel, Smits, Lisa M., Grzyb, Kamil, Perfeito, Rita, Hoel, Fredrik, Qing, Xiaobing, Ohnmacht, Jochen, Bertacchi, Michele, Jarazo, Javier, Ignac, Tomasz, Monzel, Anna S., Gonzalez-Cano, Laura, Krüger, Rejko, Sauter, Thomas, Studer, Michèle, de Almeida, Luis Pereira, Tronstad, Karl J., Sinkkonen, Lasse, Skupin, Alexander, Schwamborn, Jens C.

“…Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We…”
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A robust protocol for the generation of human midbrain organoids by Zagare, Alise, Gobin, Matthieu, Monzel, Anna S., Schwamborn, Jens C.

“…The lack of advanced in vitro models recapitulating the human brain complexity is still a major obstacle in brain development and neurological disease…”
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OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases by Sturm, Gabriel, Karan, Kalpita R., Monzel, Anna S., Santhanam, Balaji, Taivassalo, Tanja, Bris, Céline, Ware, Sarah A., Cross, Marissa, Towheed, Atif, Higgins-Chen, Albert, McManus, Meagan J., Cardenas, Andres, Lin, Jue, Epel, Elissa S., Rahman, Shamima, Vissing, John, Grassi, Bruno, Levine, Morgan, Horvath, Steve, Haller, Ronald G., Lenaers, Guy, Wallace, Douglas C., St-Onge, Marie-Pierre, Tavazoie, Saeed, Procaccio, Vincent, Kaufman, Brett A., Seifert, Erin L., Hirano, Michio, Picard, Martin

“…Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with fatigue and multi-system disorders, are often lean, and die…”
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A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations by Sturm, Gabriel, Monzel, Anna S., Karan, Kalpita R., Michelson, Jeremy, Ware, Sarah A., Cardenas, Andres, Lin, Jue, Bris, Céline, Santhanam, Balaji, Murphy, Michael P., Levine, Morgan E., Horvath, Steve, Belsky, Daniel W., Wang, Shuang, Procaccio, Vincent, Kaufman, Brett A., Hirano, Michio, Picard, Martin

“…Aging is a process of progressive change. To develop biological models of aging, longitudinal datasets with high temporal resolution are needed. Here we report…”
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Omics data integration suggests a potential idiopathic Parkinson’s disease signature by Zagare, Alise, Preciat, German, Nickels, Sarah. L., Luo, Xi, Monzel, Anna S., Gomez-Giro, Gemma, Robertson, Graham, Jaeger, Christian, Sharif, Jafar, Koseki, Haruhiko, Diederich, Nico J., Glaab, Enrico, Fleming, Ronan M. T., Schwamborn, Jens C.

“…The vast majority of Parkinson’s disease cases are idiopathic. Unclear etiology and multifactorial nature complicate the comprehension of disease pathogenesis…”
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Treating Parkinson's Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration by Mendes-Pinheiro, Bárbara, Campos, Jonas, Marote, Ana, Soares-Cunha, Carina, Nickels, Sarah L, Monzel, Anna S, Cibrão, Jorge R, Loureiro-Campos, Eduardo, Serra, Sofia C, Barata-Antunes, Sandra, Duarte-Silva, Sara, Pinto, Luísa, Schwamborn, Jens C, Salgado, António J

“…Parkinson's disease (PD) is the most common movement disorder, characterized by the progressive loss of dopaminergic neurons from the nigrostriatal system…”
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The energetics of cellular life transitions by Monzel, Anna S, Levin, Michael, Picard, Martin

“…Major life transitions are always difficult because change costs energy. Recent findings have demonstrated how mitochondrial oxidative phosphorylation (OxPhos)…”
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Cellular specificity of mitochondrial and immunometabolic features in major depression by Brasanac, Jelena, Gamradt, Stefanie, Otte, Christian, Milaneschi, Yuri, Monzel, Anna S., Picard, Martin, Gold, Stefan M.

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Glucocorticoid and Adrenergic Receptor Distribution Across Human Organs and Tissues: A Map for Stress Transduction by Basarrate, Sophia, Monzel, Anna S, Smith, Janell L M, Marsland, Anna L, Trumpff, Caroline, Picard, Martin

“…Psychosocial stress is transduced into disease risk through energy-dependent release of hormones from the hypothalamic-pituitary-adrenal and…”
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Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging by Bobba-Alves, Natalia, Sturm, Gabriel, Lin, Jue, Ware, Sarah A., Karan, Kalpita R., Monzel, Anna S., Bris, Céline, Procaccio, Vincent, Lenaers, Guy, Higgins-Chen, Albert, Levine, Morgan, Horvath, Steve, Santhanam, Balaji S., Kaufman, Brett A., Hirano, Michio, Epel, Elissa, Picard, Martin

“…Stress triggers anticipatory physiological responses that promote survival, a phenomenon termed allostasis. However, the chronic activation of energy-dependent…”
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Epitope imprinting of alpha-synuclein for sensing in Parkinson's brain organoid culture medium by Lee, Mei-Hwa, Thomas, James L., Su, Zi-Lin, Yeh, Wen-Kuan, Monzel, Anna S., Bolognin, Silvia, Schwamborn, Jens C., Yang, Chien-Hsin, Lin, Hung-Yin

“…Parkinson's disease (PD) is a progressive nervous system disorder that affects movement, whose early signs may be mild and unnoticed. α-Synuclein has been…”
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Psychosocial experiences are associated with human brain mitochondrial biology by Trumpff, Caroline, Monzel, Anna S, Sandi, Carmen, Menon, Vilas, Klein, Hans-Ulrich, Fujita, Masashi, Lee, Annie, Petyuk, Vladislav A, Hurst, Cheyenne, Duong, Duc M, Seyfried, Nicholas T, Wingo, Aliza P, Wingo, Thomas S, Wang, Yanling, Thambisetty, Madhav, Ferrucci, Luigi, Bennett, David A, De Jager, Philip L, Picard, Martin

“…Psychosocial experiences affect brain health and aging trajectories, but the molecular pathways underlying these associations remain unclear. Normal brain…”
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Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐Cyclodextrin Treatment by Jarazo, Javier, Barmpa, Kyriaki, Modamio, Jennifer, Saraiva, Cláudia, Sabaté‐Soler, Sònia, Rosety, Isabel, Griesbeck, Anne, Skwirblies, Florian, Zaffaroni, Gaia, Smits, Lisa M., Su, Jihui, Arias‐Fuenzalida, Jonathan, Walter, Jonas, Gomez‐Giro, Gemma, Monzel, Anna S., Qing, Xiaobing, Vitali, Armelle, Cruciani, Gerald, Boussaad, Ibrahim, Brunelli, Francesco, Jäger, Christian, Rakovic, Aleksandar, Li, Wen, Yuan, Lin, Berger, Emanuel, Arena, Giuseppe, Bolognin, Silvia, Schmidt, Ronny, Schröder, Christoph, Antony, Paul M.A., Klein, Christine, Krüger, Rejko, Seibler, Philip, Schwamborn, Jens C.

“…ABSTRACT Background The etiology of Parkinson's disease (PD) is only partially understood despite the fact that environmental causes, risk factors, and…”
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