Search Results - "Monument, Michael J"

Modeling Alveolar Soft Part Sarcomagenesis in the Mouse: A Role for Lactate in the Tumor Microenvironment by Goodwin, Matthew L., Jin, Huifeng, Straessler, Krystal, Smith-Fry, Kyllie, Zhu, Ju-Fen, Monument, Michael J., Grossmann, Allie, Randall, R. Lor, Capecchi, Mario R., Jones, Kevin B.

“…Alveolar soft part sarcoma (ASPS), a deadly soft tissue malignancy with a predilection for adolescents and young adults, associates consistently with t(X;17)…”
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Is Use of BMP-2 Associated with Tumor Growth and Osteoblastic Differentiation in Murine Models of Osteosarcoma? by Kendal, Joseph K., Singla, Arvind, Affan, Asmaa, Hildebrand, Kurt, Al-Ani, Abdullah, Ungrin, Mark, Mahoney, Douglas J., Itani, Doha, Jirik, Frank R., Monument, Michael J.

“…The putative benefit of rhBMP-2 is in the setting of limb reconstruction using structural allografts, whether it be allograft-prosthetic composites,…”
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VSV∆M51 drives CD8+ T cell-mediated tumour regression through infection of both cancer and non-cancer cells by Rajwani, Jahanara, Vishnevskiy, Daniil, Turk, Madison, Naumenko, Victor, Gafuik, Chris, Kim, Dae-Sun, Mah, Laura K., Snelling, Shannon, Gonzales, Gerone A., Xue, Jingna, Chanda, Ayan, Potts, Kyle G., Todesco, Hayley M., Lau, Keith C. K., Hildebrand, Karys M., Chan, Jennifer A., Liao, Shan, Monument, Michael J., Hyrcza, Martin, Bose, Pinaki, Jenne, Craig N., Canton, Johnathan, Zemp, Franz J., Mahoney, Douglas J.

“…Oncolytic viruses (OV) are designed to selectively infect and kill cancer cells, while simultaneously eliciting antitumour immunity. The mechanism is expected…”
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Effectiveness of immune checkpoint inhibitor therapy on bone metastases in non-small-cell lung cancer by Abbott, Annalise G, Meyers, Daniel E, Elmi-Assadzadeh, Golpira, Stukalin, Igor, Marro, Alessandro, Puloski, Shannon K T, Morris, Don G, Cheung, Winson Y, Monument, Michael J

“…Bone metastases (BoMs) are prevalent in patients with metastatic non-small-cell lung cancer (NSCLC) however, there are limited data detailing how BoMs respond…”
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Communication in surgical decision-making while managing metastatic bone disease: matching patient expectations with surgical goals by Barton, Kristen I., Hazenbiller, Olesja, Freeman, Georgina, Kashluba, Kayla, Ball, Melvin, Aboutaha, Abir, Puloski, Shannon K. T., Monument, Michael J.

“…Background There is a paucity of research examining how surgical decision-making for metastatic bone disease (MBD) can be optimized to improve quality of life…”
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Does surgical technique influence the burden of lung metastases in patients with pathologic long bone fractures? by Kendal, Joseph K, Heard, Bryan J, Abbott, Annalise G, Moorman, Scott W, Saini, Raghav, Puloski, Shannon K T, Monument, Michael J

“…The aims of this study are to (1) determine whether fixation of metastatic long bone fractures with an intramedullary nail (IMN) influences the incidence of…”
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The KrasG12D;Trp53fl/fl murine model of undifferentiated pleomorphic sarcoma is macrophage dense, lymphocyte poor, and resistant to immune checkpoint blockade by Hildebrand, Karys M., Singla, Arvind K., McNeil, Reid, Marritt, Kayla L., Hildebrand, Kurt N., Zemp, Franz, Rajwani, Jahanara, Itani, Doha, Bose, Pinaki, Mahoney, Douglas J., Jirik, Frank R., Monument, Michael J.

“…Sarcomas are rare, difficult to treat, mesenchymal lineage tumours that affect children and adults. Immunologically-based therapies have improved outcomes for…”
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Intratumoral STING activation causes durable immunogenic tumor eradication in the KP soft tissue sarcoma model by Marritt, Kayla L, Hildebrand, Karys M, Hildebrand, Kurt N, Singla, Arvind K, Zemp, Franz J, Mahoney, Douglas J, Jirik, Frank R, Monument, Michael J

“…Soft tissue sarcomas (STS) are highly metastatic, connective-tissue lineage solid cancers. Immunologically, sarcomas are frequently characterized by a paucity…”
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A scoping review on the surgical management of metastatic bone disease of the extremities by Kendal, Joseph K, Abbott, Annalise, Kooner, Sahil, Johal, Herman, Puloski, Shannon K T, Monument, Michael J

“…Management of metastatic bone disease of the extremities (MBD-E) is challenging, and surgical directions pose significant implications for overall patient…”
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Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group by Monument, Michael J, Johnson, Kirsten M, McIlvaine, Elizabeth, Abegglen, Lisa, Watkins, W Scott, Jorde, Lynn B, Womer, Richard B, Beeler, Natalie, Monovich, Laura, Lawlor, Elizabeth R, Bridge, Julia A, Schiffman, Joshua D, Krailo, Mark D, Randall, R Lor, Lessnick, Stephen L

“…The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood. EWS/FLI and related EWS/ETS chimeras upregulate numerous gene…”
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Posttraumatic elbow contractures: targeting neuroinflammatory fibrogenic mechanisms by Monument, Michael J., Hart, David A., Salo, Paul T., Hildebrand, Kevin A., Dean Befus, A.

“…Posttraumatic elbow stiffness remains a common and challenging clinical problem. In the setting of a congruent articular surface, the joint capsule is regarded…”
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The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures by Monument, Michael J., Hart, David A., Befus, A. Dean, Salo, Paul T., Zhang, Mei, Hildebrand, Kevin A.

“…Objectives Using a rabbit model of post-traumatic joint contractures, we investigated whether treatment with a mast cell stabilizer after joint injury would…”
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Novel Applications of Osseointegration in Orthopedic Limb Salvage Surgery by Monument, Michael J., MD, Lerman, Daniel M., MD, Randall, R. Lor, MD, FACS

“…Osseointegration is a biologic process vital to modern endoprosthetic fixation in orthopedic surgery. Numerous engineering advancements have improved the…”
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The 2022 American-British-Canadian (ABC) Traveling Fellowship: The Post-Pandemic Tour by Mesfin, Addisu, Carsen, Sasha, Dickens, Jonathan F., Eward, William, Miller, Anna N., Protopsaltis, Themistocles, Monument, Michael J.

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Molecular Confirmation of Ewing Sarcoma in an 85-Year-Old Woman by Monument, Michael J., Grossmann, Allie H., Baker, Christine C., Randall, R. Lor, Liu, Ting, Albertson, Daniel J.

“…We report a case of a Ewing sarcoma/primitive neuroectodermal tumor in an 85-year-old woman who presented with an enlarging circumscribed left flank mass…”
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Does the source of hemarthrosis influence posttraumatic joint contracture and biomechanical properties of the joint? by Horisberger, Monika, Kazemkhani, Shermin, Monument, Michael J, Emmenegger, Daniela, Hildebrand, Kevin A, Herzog, Walter

“…Abstract Background Posttraumatic joint contracture is a common complication of intraarticular injuries and an associated traumatic hemarthrosis could be of…”
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Emerging innovations and advancements in the field of musculoskeletal oncology by Randall, R. Lor, Theriault, Raminta V., Thorpe, Steven W., Monument, Michael J.

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Rotationplasty: Beauty is in the Eye of the Beholder by Bernthal, Nicholas M., MD, Monument, Michael J., MD, Lor Randall, R., MD, FACS, Jones, Kevin B., MD

“…Rotationplasty is an alternative reconstructive strategy after sarcoma resection that often gets overlooked due to concerns about cosmesis. “Rotating” a distal…”
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Venous thromboembolism rates in patients with bone and soft tissue sarcoma of the extremities following surgical resection: A systematic review by Krzyzaniak, Halli, You, Daniel Z., Mosca, Giulianna, Monument, Michael J., Schneider, Prism S.

“…Background Patients undergoing an orthopedic surgery for bone or soft tissue sarcoma are at increased venous thromboembolism (VTE) risk. Unfortunately, there…”
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Emerging innovations and advancements in the treatment of extremity and truncal soft tissue sarcomas by Walker, Kyle, Simister, Samuel K., Carr‐Ascher, Janai, Monument, Michael J., Thorpe, Steven W., Randall, R. Lor

“…In this special edition update on soft tissue sarcomas (STS), we cover classifications, emerging technologies, prognostic tools, radiation schemas, and…”
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