Search Results - "Montoya, Alba L"

Evaluation of the Topology Space of DNA-Encoded Libraries by Weigel, William K., Montoya, Alba L., Franzini, Raphael M.

“…DNA-encoded libraries (DELs) are widely used in the discovery of drug candidates, and understanding their design principles is critical for accessing better…”
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Specific Recognition of β-Galactofuranose-Containing Glycans of Synthetic Neoglycoproteins by Sera of Chronic Chagas Disease Patients by Montoya, Alba L, Gil, Eileni R, Heydemann, Emily L, Estevao, Igor L, Luna, Bianca E, Ellis, Cameron C, Jankuru, Sohan R, Alarcón de Noya, Belkisyolé, Noya, Oscar, Zago, Maria Paola, Almeida, Igor C, Michael, Katja

“…Chagas disease (CD) can be accurately diagnosed by detecting in patients' blood using polymerase chain reaction (PCR). However, parasite-derived biomarkers are…”
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An α-Gal-containing neoglycoprotein-based vaccine partially protects against murine cutaneous leishmaniasis caused by Leishmania major by Iniguez, Eva, Schocker, Nathaniel S, Subramaniam, Krishanthi, Portillo, Susana, Montoya, Alba L, Al-Salem, Waleed S, Torres, Caresse L, Rodriguez, Felipe, Moreira, Otacilio C, Acosta-Serrano, Alvaro, Michael, Katja, Almeida, Igor C, Maldonado, Rosa A

“…Protozoan parasites from the genus Leishmania cause broad clinical manifestations known as leishmaniases, which affect millions of people worldwide. Cutaneous…”
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A Branched and Double Alpha-Gal-Bearing Synthetic Neoglycoprotein as a Biomarker for Chagas Disease by Montoya, Alba L, Carvajal, Elisa G, Ortega-Rodriguez, Uriel, Estevao, Igor L, Ashmus, Roger A, Jankuru, Sohan R, Portillo, Susana, Ellis, Cameron C, Knight, Colin D, Alonso-Padilla, Julio, Izquierdo, Luis, Pinazo, Maria-Jesus, Gascon, Joaquim, Suarez, Veronica, Watts, Douglas M, Malo, Iliana R, Ramsey, Janine M, Alarcón De Noya, Belkisyolé, Noya, Oscar, Almeida, Igor C, Michael, Katja

“…Chagas disease (CD) is caused by the parasite and affects 6-7 million people worldwide. The diagnosis is still challenging, due to extensive parasite diversity…”
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Serodiagnosis and therapeutic monitoring of New-World tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins by Viana, Sayonara M., Montoya, Alba L., Carvalho, Augusto M., de Mendonça, Brunele S., Portillo, Susana, Olivas, Janet J., Karimi, Nasim H., Estevao, Igor L., Ortega-Rodriguez, Uriel, Carvalho, Edgar M., Dutra, Walderez O., Maldonaldo, Rosa A., Michael, Katja, de Oliveira, Camila I., Almeida, Igor C.

“…American tegumentary leishmaniasis (TL) caused by Leishmania braziliensis is characterized by a spectrum of clinical presentations, ranging from localized…”
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Reversed Immunoglycomics Identifies α-Galactosyl-Bearing Glycotopes Specific for Leishmania major Infection by Montoya, Alba L., Austin, Victoria M., Portillo, Susana, Vinales, Irodiel, Ashmus, Roger A., Estevao, Igor, Jankuru, Sohan R., Alraey, Yasser, Al-Salem, Waleed S., Acosta-Serrano, Álvaro, Almeida, Igor C., Michael, Katja

“…All healthy humans have high levels of natural anti-α-galactosyl (α-Gal) antibodies (elicited by yet uncharacterized glycotopes), which may play important…”
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Elucidating the Unconventional Binding Mode of a DNA‐Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development by You, Weijie, Montoya, Alba L., Dana, Srikanta, Franzini, Raphael M., Steegborn, Clemens

“…Sirtuin 6 (Sirt6), an NAD+‐dependent deacylase, has emerged as a promising target for aging‐related diseases and cancer. Advancing the medicinal chemistry of…”
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Combining pharmacophore models derived from DNA-encoded chemical libraries with structure-based exploration to predict Tankyrase 1 inhibitors by Montoya, Alba L., Glavatskikh, Marta, Halverson, Brayden J., Yuen, Lik Hang, Schüler, Herwig, Kireev, Dmitri, Franzini, Raphael M.

“…DNA-encoded chemical libraries (DECLs) interrogate the interactions of a target of interest with vast numbers of molecules. DECLs hence provide abundant…”
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Big is not better: Comparing two alpha-Gal-bearing glycotopes in neoglycoproteins as biomarkers for Leishmania (Viannia) braziliensis infection by Montoya, Alba L., Gil, Eileni R., Vinales, Irodiel, Estevao, Igor L., Taboada, Paola, Torrico, Mary Cruz, Torrico, Faustino, Marco, Jorge Diego, Almeida, Igor C., Michael, Katja

“…The protozoan parasite Leishmania (Viannia) braziliensis is among Latin America's most widespread Leishmania species and is responsible for tegumentary…”
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Anti-α-Gal antibodies detected by novel neoglycoproteins as a diagnostic tool for Old World cutaneous leishmaniasis caused by Leishmania major by Subramaniam, Krishanthi S, Austin, Victoria, Schocker, Nathaniel S, Montoya, Alba L, Anderson, Matthew S, Ashmus, Roger A, Mesri, Mina, Al-Salem, Waleed, Almeida, Igor C, Michael, Katja, Acosta-Serrano, Alvaro

“…Outbreaks of Old World cutaneous leishmaniasis (CL) have significantly increased due to the conflicts in the Middle East, with most of the cases occurring in…”
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An [alpha]-Gal-containing neoglycoprotein-based vaccine partially protects against murine cutaneous leishmaniasis caused by Leishmania major by Subramaniam, Krishanthi, Maldonado, Rosa A, Iniguez, Eva, Montoya, Alba L, Al-Salem, Waleed S, Rodriguez, Felipe, Schocker, Nathaniel S, Portillo, Susana, Michael, Katja, Acosta-Serrano, Alvaro, Moreira, Otacilio C, Almeida, Igor C, Torres, Caresse L

“…Background Protozoan parasites from the genus Leishmania cause broad clinical manifestations known as leishmaniases, which affect millions of people worldwide…”
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