Search Results - "Montoir, David"
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Differential Functionalization of 1,6-Naphthyridin-2(1H)-ones through Sequential One-Pot Suzuki-Miyaura Cross-Couplings
Published in European journal of organic chemistry (01-03-2014)“…A practical synthesis of 7‐chloro‐3‐iodo‐1‐methyl‐1,6‐naphthyridin‐2(1H)‐one is described that starts from 2‐chloro‐4‐(methylamino)nicotinaldehyde. The dihalo…”
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Crystal Structure of N-(7-{[2-(Dimethylamino)ethyl]amino}-1-methyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-3,4,5-trimethoxybenzamide
Published in X-ray Structure Analysis Online (2017)“…The X-ray crystal structure of N-(7-{[2-(dimethylamino)ethyl]amino}-1-methyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-3,4,5-trimethoxybenzamide, a potential…”
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3
Synthesis of (1 → 2)-S-Linked Saccharides and S‑Linked Glycoconjugates via a Palladium-G3-XantPhos Precatalyst Catalysis
Published in Journal of organic chemistry (07-07-2017)“…Buchwald–Hartwig–Migita cross-coupling of 1-thiosugars with 2-iodoglycals has been accomplished under mild and operationally simple reaction conditions through…”
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New azole antifungals with a fused triazinone scaffold
Published in European journal of medicinal chemistry (01-03-2020)“…We identified a new series of azole antifungal agents bearing a pyrrolotriazinone scaffold. These compounds exhibited a broad in vitro antifungal activity…”
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Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation
Published in Chemical science (Cambridge) (14-12-2018)“…We describe herein a Pd-catalyzed methodology for the thioglycoconjugation of iodoaryl peptides and aminoacids. This operationally simple process occurs under…”
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Novel approach towards 3,7-disubstituted 1,6-naphthyridin-4(1H)-ones exploiting cross-coupling and SNAr reactions of a dihalogenated compound
Published in Tetrahedron letters (26-09-2018)“…[Display omitted] •A new access to 3,7-disubstituted 1,6-naphthyridin-4(1H)-ones.•Differential functionalization of…”
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Structure–Activity Relationship Studies of Retro‑1 Analogues against Shiga Toxin
Published in Journal of medicinal chemistry (13-08-2020)“…High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from…”
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Efficient one-pot synthesis of 3,7-disubstituted 1,6-naphthyridin-2(1H)-ones through regioselective palladium-catalyzed cross-coupling and SNAr reactions
Published in Tetrahedron (27-05-2015)“…An efficient synthesis of original 3,7-disubstituted 1,6-naphthyridones via one-pot palladium-catalyzed cross-coupling and SNAr reactions is reported…”
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Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugationElectronic supplementary information (ESI) available: General, experimental procedures, and characterization of all new compounds. See DOI: 10.1039/c8sc02370k
Published 28-11-2018“…We describe herein a Pd-catalyzed methodology for the thioglycoconjugation of iodoaryl peptides and aminoacids. This operationally simple process occurs under…”
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Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation† †Electronic supplementary information (ESI) available: General, experimental procedures, and characterization of all new compounds. See DOI: 10.1039/c8sc02370k
Published in Chemical science (Cambridge) (20-09-2018)“…A highly chemoselective thioglycoconjugation method of iodoaryl aminoacids, small peptides and complex unprotected polypeptides is reported. We describe herein…”
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Novel 1,6-naphthyridin-2(1H)-ones as potential anticancer agents targeting Hsp90
Published in European journal of medicinal chemistry (25-08-2016)“…Hsp90 is an ATP-dependent chaperone known to be overexpressed in many cancers. This way, Hsp90 is an important target for drug discovery. Novobiocin, an…”
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