Search Results - "Montine, Thomas J"

A visual–language foundation model for pathology image analysis using medical Twitter by Huang, Zhi, Bianchi, Federico, Yuksekgonul, Mert, Montine, Thomas J., Zou, James

“…The lack of annotated publicly available medical images is a major barrier for computational research and education innovations. At the same time, many…”
Get full text

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis by Irwin, David J, Dr, Grossman, Murray, MD, Weintraub, Daniel, MD, Hurtig, Howard I, MD, Duda, John E, MD, Xie, Sharon X, PhD, Lee, Edward B, MD, Van Deerlin, Vivianna M, MD, Lopez, Oscar L, MD, Kofler, Julia K, MD, Nelson, Peter T, MD, Jicha, Gregory A, MD, Woltjer, Randy, MD, Quinn, Joseph F, MD, Kaye, Jeffery, MD, Leverenz, James B, MD, Tsuang, Debby, MD, Longfellow, Katelan, MD, Yearout, Dora, BS, Kukull, Walter, PhD, Keene, C Dirk, MD, Montine, Thomas J, MD, Zabetian, Cyrus P, MD, Trojanowski, John Q, MD

“…Summary Background Great heterogeneity exists in survival and the interval between onset of motor symptoms and dementia symptoms across synucleinopathies. We…”
Get full text

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report by Nelson, Peter T, Dickson, Dennis W, Trojanowski, John Q, Jack, Clifford R, Boyle, Patricia A, Arfanakis, Konstantinos, Rademakers, Rosa, Alafuzoff, Irina, Attems, Johannes, Brayne, Carol, Coyle-Gilchrist, Ian T S, Chui, Helena C, Fardo, David W, Flanagan, Margaret E, Halliday, Glenda, Hokkanen, Suvi R K, Hunter, Sally, Jicha, Gregory A, Katsumata, Yuriko, Kawas, Claudia H, Keene, C Dirk, Kovacs, Gabor G, Kukull, Walter A, Levey, Allan I, Makkinejad, Nazanin, Montine, Thomas J, Murayama, Shigeo, Murray, Melissa E, Nag, Sukriti, Rissman, Robert A, Seeley, William W, Sperling, Reisa A, White, 3rd, Charles L, Yu, Lei, Schneider, Julie A

“…We describe a recently recognized disease entity, limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE neuropathological change (LATE-NC) is…”
Get full text

Angiotensin-converting enzyme 2 (ACE2) expression increases with age in patients requiring mechanical ventilation by Baker, Steven Andrew, Kwok, Shirley, Berry, Gerald J, Montine, Thomas J

“…Mortality due to Covid-19 is highly associated with advanced age, owing in large part to severe lower respiratory tract infection. SARS-CoV-2 utilizes the host…”
Get full text

Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial by Craft, Suzanne, Claxton, Amy, Baker, Laura D, Hanson, Angela J, Cholerton, Brenna, Trittschuh, Emily H, Dahl, Deborah, Caulder, Erin, Neth, Bryan, Montine, Thomas J, Jung, Youngkyoo, Maldjian, Joseph, Whitlow, Christopher, Friedman, Seth

“…Long acting insulin detemir administered intranasally for three weeks enhanced memory for adults with Alzheimer's disease dementia (AD) or amnestic mild…”
Get more information

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach by Montine, Thomas J., Phelps, Creighton H., Beach, Thomas G., Bigio, Eileen H., Cairns, Nigel J., Dickson, Dennis W., Duyckaerts, Charles, Frosch, Matthew P., Masliah, Eliezer, Mirra, Suzanne S., Nelson, Peter T., Schneider, Julie A., Thal, Dietmar Rudolf, Trojanowski, John Q., Vinters, Harry V., Hyman, Bradley T.

“…We present a practical guide for the implementation of recently revised National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic…”
Get full text

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease by Snyder, Heather M, Corriveau, Roderick A, Craft, Suzanne, Faber, James E, Greenberg, Steven M, Knopman, David, Lamb, Bruce T, Montine, Thomas J, Nedergaard, Maiken, Schaffer, Chris B, Schneider, Julie A, Wellington, Cheryl, Wilcock, Donna M, Zipfel, Gregory J, Zlokovic, Berislav, Bain, Lisa J, Bosetti, Francesca, Galis, Zorina S, Koroshetz, Walter, Carrillo, Maria C

“…Abstract Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease…”
Get full text

Neuropathologic substrates of Parkinson disease dementia by Irwin, David J., White, Matthew T., Toledo, Jon B., Xie, Sharon X., Robinson, John L., Van Deerlin, Vivianna, Lee, Virginia M.-Y., Leverenz, James B., Montine, Thomas J., Duda, John E., Hurtig, Howard I., Trojanowski, John Q.

“…Objective: A study was undertaken to examine the neuropathological substrates of cognitive dysfunction and dementia in Parkinson disease (PD). Methods: One…”
Get full text

Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts by Nelson, Peter T., Brayne, Carol, Flanagan, Margaret E., Abner, Erin L., Agrawal, Sonal, Attems, Johannes, Castellani, Rudolph J., Corrada, Maria M., Cykowski, Matthew D., Di, Jing, Dickson, Dennis W., Dugger, Brittany N., Ervin, John F., Fleming, Jane, Graff-Radford, Jonathan, Grinberg, Lea T., Hokkanen, Suvi R. K., Hunter, Sally, Kapasi, Alifiya, Kawas, Claudia H., Keage, Hannah A. D., Keene, C. Dirk, Kero, Mia, Knopman, David S., Kouri, Naomi, Kovacs, Gabor G., Labuzan, Sydney A., Larson, Eric B., Latimer, Caitlin S., Leite, Renata E. P., Matchett, Billie J., Matthews, Fiona E., Merrick, Richard, Montine, Thomas J., Murray, Melissa E., Myllykangas, Liisa, Nag, Sukriti, Nelson, Ruth S., Neltner, Janna H., Nguyen, Aivi T., Petersen, Ronald C., Polvikoski, Tuomo, Reichard, R. Ross, Rodriguez, Roberta D., Suemoto, Claudia K., Wang, Shih-Hsiu J., Wharton, Stephen B., White, Lon, Schneider, Julie A.

“…Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and Alzheimer’s disease neuropathologic change (ADNC) are each associated…”
Get full text

MIBI-TOF: A multiplexed imaging platform relates cellular phenotypes and tissue structure by Keren, Leeat, Bosse, Marc, Thompson, Steve, Risom, Tyler, Vijayaragavan, Kausalia, McCaffrey, Erin, Marquez, Diana, Angoshtari, Roshan, Greenwald, Noah F, Fienberg, Harris, Wang, Jennifer, Kambham, Neeraja, Kirkwood, David, Nolan, Garry, Montine, Thomas J, Galli, Stephen J, West, Robert, Bendall, Sean C, Angelo, Michael

“…Understanding tissue structure and function requires tools that quantify the expression of multiple proteins while preserving spatial information. Here, we…”
Get full text

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease by Hyman, Bradley T, Phelps, Creighton H, Beach, Thomas G, Bigio, Eileen H, Cairns, Nigel J, Carrillo, Maria C, Dickson, Dennis W, Duyckaerts, Charles, Frosch, Matthew P, Masliah, Eliezer, Mirra, Suzanne S, Nelson, Peter T, Schneider, Julie A, Thal, Dietmar Rudolf, Thies, Bill, Trojanowski, John Q, Vinters, Harry V, Montine, Thomas J

“…Abstract A consensus panel from the United States and Europe was convened recently to update and revise the 1997 consensus guidelines for the neuropathologic…”
Get full text

LATE-NC staging in routine neuropathologic diagnosis: an update by Nelson, Peter T., Lee, Edward B., Cykowski, Matthew D., Alafuzoff, Irina, Arfanakis, Konstantinos, Attems, Johannes, Brayne, Carol, Corrada, Maria M., Dugger, Brittany N., Flanagan, Margaret E., Ghetti, Bernardino, Grinberg, Lea T., Grossman, Murray, Grothe, Michel J., Halliday, Glenda M., Hasegawa, Masato, Hokkanen, Suvi R. K., Hunter, Sally, Jellinger, Kurt, Kawas, Claudia H., Keene, C. Dirk, Kouri, Naomi, Kovacs, Gabor G., Leverenz, James B., Latimer, Caitlin S., Mackenzie, Ian R., Mao, Qinwen, McAleese, Kirsty E., Merrick, Richard, Montine, Thomas J., Murray, Melissa E., Myllykangas, Liisa, Nag, Sukriti, Neltner, Janna H., Newell, Kathy L., Rissman, Robert A., Saito, Yuko, Sajjadi, S. Ahmad, Schwetye, Katherine E., Teich, Andrew F., Thal, Dietmar R., Tomé, Sandra O., Troncoso, Juan C., Wang, Shih-Hsiu J., White, Charles L., Wisniewski, Thomas, Yang, Hyun-Sik, Schneider, Julie A., Dickson, Dennis W., Neumann, Manuela

“…An international consensus report in 2019 recommended a classification system for limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes…”
Get full text

Engineering monocyte/macrophage−specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing by Scharenberg, Samantha G., Poletto, Edina, Lucot, Katherine L., Colella, Pasqualina, Sheikali, Adam, Montine, Thomas J., Porteus, Matthew H., Gomez-Ospina, Natalia

“…Gaucher disease is a lysosomal storage disorder caused by insufficient glucocerebrosidase activity. Its hallmark manifestations are attributed to infiltration…”
Get full text

Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias by Beecham, Gary W, Hamilton, Kara, Naj, Adam C, Martin, Eden R, Huentelman, Matt, Myers, Amanda J, Corneveaux, Jason J, Hardy, John, Vonsattel, Jean-Paul, Younkin, Steven G, Bennett, David A, De Jager, Philip L, Larson, Eric B, Crane, Paul K, Kamboh, M Ilyas, Kofler, Julia K, Mash, Deborah C, Duque, Linda, Gilbert, John R, Gwirtsman, Harry, Buxbaum, Joseph D, Kramer, Patricia, Dickson, Dennis W, Farrer, Lindsay A, Frosch, Matthew P, Ghetti, Bernardino, Haines, Jonathan L, Hyman, Bradley T, Kukull, Walter A, Mayeux, Richard P, Pericak-Vance, Margaret A, Schneider, Julie A, Trojanowski, John Q, Reiman, Eric M, Schellenberg, Gerard D, Montine, Thomas J

“…Alzheimer's disease (AD) and related dementias are a major public health challenge and present a therapeutic imperative for which we need additional insight…”
Get full text

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease by Sperling, Reisa A, Aisen, Paul S, Beckett, Laurel A, Bennett, David A, Craft, Suzanne, Fagan, Anne M, Iwatsubo, Takeshi, Jack, Clifford R, Kaye, Jeffrey, Montine, Thomas J, Park, Denise C, Reiman, Eric M, Rowe, Christopher C, Siemers, Eric, Stern, Yaakov, Yaffe, Kristine, Carrillo, Maria C, Thies, Bill, Morrison-Bogorad, Marcelle, Wagster, Molly V, Phelps, Creighton H

“…Abstract The pathophysiological process of Alzheimer’s disease (AD) is thought to begin many years before the diagnosis of AD dementia. This long “preclinical”…”
Get full text

The future of blood-based biomarkers for Alzheimer's disease by Henriksen, Kim, O’Bryant, Sid E, Hampel, Harald, Trojanowski, John Q, Montine, Thomas J, Jeromin, Andreas, Blennow, Kaj, Lönneborg, Anders, Wyss-Coray, Tony, Soares, Holly, Bazenet, Chantal, Sjögren, Magnus, Hu, William, Lovestone, Simon, Karsdal, Morten A, Weiner, Michael W

“…Abstract Treatment of Alzheimer's disease (AD) is significantly hampered by the lack of easily accessible biomarkers that can detect disease presence and…”
Get full text

Concepts for brain aging: resistance, resilience, reserve, and compensation by Montine, Thomas J, Cholerton, Brenna A, Corrada, Maria M, Edland, Steven D, Flanagan, Margaret E, Hemmy, Laura S, Kawas, Claudia H, White, Lon R

“…A primary goal of research in cognitive impairment and dementia is to understand how some individuals retain sufficient cognitive function for a fulfilling…”
Get full text

Male microchimerism in the human female brain by Chan, William F N, Gurnot, Cécile, Montine, Thomas J, Sonnen, Joshua A, Guthrie, Katherine A, Nelson, J Lee

“…In humans, naturally acquired microchimerism has been observed in many tissues and organs. Fetal microchimerism, however, has not been investigated in the…”
Get full text

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer’s disease by Bai, Bing, Hales, Chadwick M., Chen, Ping-Chung, Gozal, Yair, Dammer, Eric B., Fritz, Jason J., Wang, Xusheng, Xia, Qiangwei, Duong, Duc M., Street, Craig, Cantero, Gloria, Cheng, Dongmei, Jones, Drew R., Wu, Zhiping, Li, Yuxin, Diner, Ian, Heilman, Craig J., Rees, Howard D., Wu, Hao, Li Lin, Szulwach, Keith E., Gearing, Marla, Mufson, Elliott J., Bennett, David A., Montin, Thomas J., Seyfried, Nicholas T., Wingo, Thomas S., Yi E. Sun, Jin, Peng, Hanfelt, John, Willcock, Donna M., Levey, Allan, Lah, James J., Peng, Junmin

“…Deposition of insoluble protein aggregates is a hallmark of neurodegenerative diseases. The universal presence of β-amyloid and tau in Alzheimer’s disease (AD)…”
Get full text

Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression by Shi, Min, Bradner, Joshua, Hancock, Aneeka M., Chung, Kathryn A., Quinn, Joseph F., Peskind, Elaine R., Galasko, Douglas, Jankovic, Joseph, Zabetian, Cyrus P., Kim, Hojoong M., Leverenz, James B., Montine, Thomas J., Ginghina, Carmen, Kang, Un Jung, Cain, Kevin C., Wang, Yu, Aasly, Jan, Goldstein, David, Zhang, Jing

“…Objective: There is a clear need to develop biomarkers for Parkinson disease (PD) diagnosis, differential diagnosis of Parkinsonian disorders, and monitoring…”
Get full text