Search Results - "Montine, T"

Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease by LI, G, LARSON, E. B, SONNEN, J. A, SHOFER, J. B, PETRIE, E. C, SCHANTZ, A, PESKIND, E. R, RASKIND, M. A, BREITNER, J. C. S, MONTINE, T. J

“…Treatment with 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitors ("statins") has been associated in some epidemiologic studies with reduced risk of…”
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Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease by ZAJA-MILATOVIC, S, MILATOVIC, D, SCHANTZ, A. M, ZHANG, J, MONTINE, K. S, SAMII, A, DEUTCH, A. Y, MONTINE, T. J

“…Dysfunction of neostriatal medium spiny neurons (MSNs) is hypothesized to underlie late-stage motor complications of Parkinson disease (PD). The authors…”
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Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies by Chibnik, L B, White, C C, Mukherjee, S, Raj, T, Yu, L, Larson, E B, Montine, T J, Keene, C D, Sonnen, J, Schneider, J A, Crane, P K, Shulman, J M, Bennett, D A, De Jager, P L

“…Tauopathies, including Alzheimer’s disease (AD) and other neurodegenerative conditions, are defined by a pathological hallmark: neurofibrillary tangles (NFTs)…”
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CSF tau/Aβ42 ratio for increased risk of mild cognitive impairment : A follow-up study by LI, G, SOKAL, I, MONTINE, T. J, QUINN, J. F, LEVERENZ, J. B, BRODEY, M, SCHELLENBERG, G. D, KAYE, J. A, RASKIND, M. A, ZHANG, J, PESKIND, E. R

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Association of cognitive domains with postural instability/gait disturbance in Parkinson's disease by Kelly, V.E, Johnson, C.O, McGough, E.L, Shumway-Cook, A, Horak, F.B, Chung, K.A, Espay, A.J, Revilla, F.J, Devoto, J, Wood-Siverio, C, Factor, S.A, Cholerton, B, Edwards, K.L, Peterson, A.L, Quinn, J.F, Montine, T.J, Zabetian, C.P, Leverenz, J.B

“…Abstract Introduction Research suggests an association between global cognition and postural instability/gait disturbance (PIGD) in Parkinson disease (PD), but…”
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Factors associated with resistance to dementia despite high Alzheimer disease pathology by ERTEN-LYONS, D, WOLTJER, R. L, DODGE, H, NIXON, R, VOROBIK, R, CALVERT, J. F, LEAHY, M, MONTINE, T, KAYE, J

“…Autopsy series have shown that some elderly people remain with normal cognitive function during life despite having high burdens of pathologic lesions…”
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Neural transplantation in Huntington disease : Long-term grafts in two patients by KEENE, C. D, SONNEN, J. A, SWANSON, P. D, KOPYOV, O, LEVERENZ, J. B, BIRD, T. D, MONTINE, T. J

“…Clinical trials of fetal neural tissue transplantation for Huntington disease (HD) have been conducted with variable clinical results. However, no long-term…”
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Proteasomal inhibition induced by manganese ethylene-bis-dithiocarbamate: Relevance to Parkinson's disease by ZHOU, Y, SHIE, F.-S, PICCARDO, P, MONTINE, T. J, ZHANG, J

“…Maneb, a widely used fungicide, has been associated with Parkinsonism in humans. In experimental models, maneb and its major active element, manganese…”
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LACK OF CEREBRAL BMAA IN HUMAN CEREBRAL CORTEX by SNYDER, L. R, CRUZ-AGUADO, R, SADILEK, M, GALASKO, D, SHAW, C. A, MONTINE, T. J

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A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology by Leverenz, J. B., Yu, C. E., Montine, T. J., Steinbart, E., Bekris, L. M., Zabetian, C., Kwong, L. K., Lee, V. M-Y., Schellenberg, G. D., Bird, T. D.

“…Mutations in the progranulin (GRN) gene have recently been reported as a cause of the frontotemporal dementia (FTD) syndrome. We performed a clinical,…”
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Nonsteroidal anti-inflammatory drugs are associated with increased neuritic plaques by SONNEN, J. A, LARSON, E. B, WALKER, R. L, HANEUSE, S, CRANE, P. K, GRAY, S. L, BREITNER, J. C. S, MONTINE, T. J

“…Observational and experimental studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer disease (AD); however, clinical…”
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Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor by Savonenko, A., Munoz, P., Melnikova, T., Wang, Q., Liang, X., Breyer, R.M., Montine, T.J., Kirkwood, A., Andreasson, K.

“…Cyclooxygenase-2 (COX-2) is a neuronal immediate early gene that is regulated by N-methyl d aspartate (NMDA) receptor activity. COX-2 enzymatic activity…”
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Parkinson's Disease Is Associated with Oxidative Damage to Cytoplasmic DNA and RNA in Substantia Nigra Neurons by Zhang, Jing, Perry, George, Smith, Mark A., Robertson, David, Olson, Sandra J., Graham, Doyle G., Montine, Thomas J.

“…Oxidative damage, including modification of nucleic acids, may contribute to dopaminergic neurodegeneration in the substantia nigra (SN) of patients with…”
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The Lipid Peroxidation Product 4‐Hydroxynonenal Inhibits Neurite Outgrowth, Disrupts Neuronal Microtubules, and Modifies Cellular Tubulin by Neely, M. D., Sidell, K. R., Graham, D. G., Montine, T. J.

“…: Oxidative stress is believed to be an important factor in the development of age‐related neurodegenerative diseases such as Alzheimer's disease (AD). The CNS…”
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Elevated CSF prostaglandin E2 levels in patients with probable AD by MONTINE, T. J, SIDELL, K. R, CREWS, B. C, MARKESBERY, W. R, MARNETT, L. J, ROBERTS, L. J, MORROW, J. D

“…To determine CSF eicosanoid concentrations and brain cyclo-oxygenase activity in AD patients and age-matched control subjects. Nonsteroidal anti-inflammatory…”
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Characterization of cognitive impairments and neurotransmitter changes in a novel transgenic mouse lacking Slc10a4 by Melief, E.J, Gibbs, J.T, Li, X, Morgan, R.G, Keene, C.D, Montine, T.J, Palmiter, R.D, Darvas, M

“…Highlights • Slc10a4 expression is enriched in midbrain and brainstem regions. • Slc10a4Δ/Δ mice have moderate impairment in spatial learning and cognitive…”
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Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease by Montine, T J, Markesbery, W R, Morrow, J D, Roberts, 2nd, L J

“…Postmortem studies have associated Alzheimer's disease (AD) with regionally increased oxidative damage to brain. Lacking, however, is a specific marker of…”
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Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4 by Montine, KS, Olson, SJ, Amarnath, V, Whetsell, WO, Jr, Graham, DG, Montine, TJ

“…Cumulative oxidative damage, including lipid peroxidation, is a central component of cellular aging and is thought to play a role in the pathogenesis of…”
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Selective dendritic degeneration of medium spiny neurons in dementia with Lewy bodies by ZAJA-MILATOVIC, S, KEENE, C. D, MONTINE, K. S, LEVERENZ, J. B, TSUANG, D, MONTINE, T. J

“…Dementia with Lewy bodies (DLB) is the second most common form of dementia and shows more severely impaired performance on tests of executive functions…”
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Increased CSF F2-isoprostane concentration in probable AD by MONTINE, T. J, BEAL, M. F, CUDKOWICZ, M. E, O'DONNELL, H, MARGOLIN, R. A, MCFARLAND, L, BACHRACH, A. F, ZACKERT, W. E, ROBERTS, L. J, MORROW, J. D

“…To quantify F2-isoprostane levels in CSF obtained from the lumbar cistern of patients with AD, ALS, and controls. Studies of human postmortem tissue and…”
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