Search Results - "Montilla‐García, Ángeles"

The sigma‐1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors by Ruiz‐Cantero, M. Carmen, Cortés‐Montero, Elsa, Jain, Aakanksha, Montilla‐García, Ángeles, Bravo‐Caparrós, Inmaculada, Shim, Jaehoon, Sánchez‐Blázquez, Pilar, Woolf, Clifford J., Baeyens, José M., Cobos, Enrique J.

“…Background and Purpose Peripheral sensitization contributes to pathological pain. While prostaglandin E2 (PGE2) and nerve growth factor (NGF) sensitize…”
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(+)-Methyl (1R,2S)‑2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties by Amata, Emanuele, Rescifina, Antonio, Prezzavento, Orazio, Arena, Emanuela, Dichiara, Maria, Pittalà, Valeria, Montilla-García, Ángeles, Punzo, Francesco, Merino, Pedro, Cobos, Enrique J, Marrazzo, Agostino

“…Methoxycarbonyl-1-phenyl-2-cyclopropylmethyl based derivatives cis-(+)-1a [cis-(+)-MR200], cis-(−)-1a [ cis-(−)-MR201], and trans-(±)-1a [trans-(±)-MR204],…”
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The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene by Luna‐Sánchez, Marta, Díaz‐Casado, Elena, Barca, Emanuele, Tejada, Miguel Ángel, Montilla‐García, Ángeles, Cobos, Enrique Javier, Escames, Germaine, Acuña‐Castroviejo, Dario, Quinzii, Catarina M, López, Luis Carlos

“…Primary coenzyme Q 10 (CoQ 10 ) deficiency is due to mutations in genes involved in CoQ biosynthesis. The disease has been associated with five major…”
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Potentiation of morphine-induced mechanical antinociception by σ1 receptor inhibition: Role of peripheral σ1 receptors by Sánchez-Fernández, Cristina, Nieto, Francisco Rafael, González-Cano, Rafael, Artacho-Cordón, Antonia, Romero, Lucía, Montilla-García, Ángeles, Zamanillo, Daniel, Baeyens, José Manuel, Entrena, José Manuel, Cobos, Enrique José

“…We studied the modulation of morphine-induced mechanical antinociception and side effects by σ1 receptor inhibition. Both wild-type (WT) and σ1 receptor…”
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Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation by Montilla-García, Ángeles, Tejada, Miguel Á, Ruiz-Cantero, M Carmen, Bravo-Caparrós, Inmaculada, Yeste, Sandra, Zamanillo, Daniel, Cobos, Enrique J

“…Sigma-1 receptor antagonism increases the effects of morphine on nociceptive pain, even in morphine-tolerant animals. However, it is unknown whether these…”
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Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors by Gonzalez-Cano, Rafael, Montilla-García, Ángeles, Perazzoli, Gloria, Torres, Jesús M, Cañizares, Francisco J, Fernández-Segura, Eduardo, Costigan, Michael, Baeyens, José M, Cobos, Enrique J

“…Both TRPA1 and purinergic P2X receptors have been proposed as potential targets for the treatment of visceral pain. We found that the intracolonic…”
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The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going? by González-Cano, Rafael, Montilla-García, Ángeles, Ruiz-Cantero, M. Carmen, Bravo-Caparrós, Inmaculada, Tejada, Miguel Á., Nieto, Francisco R., Cobos, Enrique J.

“…[Display omitted] •Preclinical pain measures have evolved to approximate the human pain phenotype.•Classic reflex-based pain measures in rodents needed decades…”
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Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia by Montilla-García, Ángeles, Tejada, Miguel Á., Perazzoli, Gloria, Entrena, José M., Portillo-Salido, Enrique, Fernández-Segura, Eduardo, Cañizares, Francisco J., Cobos, Enrique J.

“…Grip strength deficit is a measure of pain-induced functional disability in rheumatic disease. We tested whether this parameter and tactile allodynia, the…”
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Modulation of peripheral μ-opioid analgesia by σ1 receptors by Sánchez-Fernández, Cristina, Montilla-García, Ángeles, González-Cano, Rafael, Nieto, Francisco Rafael, Romero, Lucía, Artacho-Cordón, Antonia, Montes, Rosa, Fernández-Pastor, Begoña, Merlos, Manuel, Baeyens, José Manuel, Entrena, José Manuel, Cobos, Enrique José

“…We evaluated the effects of σ1-receptor inhibition on μ-opioid-induced mechanical antinociception and constipation. σ1-Knockout mice exhibited marked…”
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The clinical heterogeneity of coenzyme Q 10 deficiency results from genotypic differences in the Coq9 gene by Luna‐Sánchez, Marta, Díaz‐Casado, Elena, Barca, Emanuele, Tejada, Miguel Ángel, Montilla‐García, Ángeles, Cobos, Enrique Javier, Escames, Germaine, Acuña‐Castroviejo, Dario, Quinzii, Catarina M, López, Luis Carlos

“…Primary coenzyme Q 10 (CoQ 10 ) deficiency is due to mutations in genes involved in CoQ biosynthesis. The disease has been associated with five major…”
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Modality-specific peripheral antinociceptive effects of μ-opioid agonists on heat and mechanical stimuli: Contribution of sigma-1 receptors by Montilla-García, Ángeles, Perazzoli, Gloria, Tejada, Miguel Á., González-Cano, Rafael, Sánchez-Fernández, Cristina, Cobos, Enrique J., Baeyens, José M.

“…Morphine induces peripherally μ-opioid-mediated antinociception to heat but not to mechanical stimulation. Peripheral sigma-1 receptors tonically inhibit…”
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Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice by Tejada, Miguel A., Montilla-García, Angeles, Cronin, Shane J., Cikes, Domagoj, Sánchez-Fernández, Cristina, González-Cano, Rafael, Ruiz-Cantero, M. Carmen, Penninger, Josef M., Vela, José M., Baeyens, José M., Cobos, Enrique J.

“…Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors constitute a biological brake to opioid drug-induced…”
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Targeting immune-driven opioid analgesia by sigma-1 receptors: Opening the door to novel perspectives for the analgesic use of sigma-1 antagonists by Tejada, Miguel Á., Montilla-García, Ángeles, González-Cano, Rafael, Bravo-Caparrós, Inmaculada, Ruiz-Cantero, M. Carmen, Nieto, Francisco R., Cobos, Enrique J.

“…[Display omitted] Immune cells have a known role in pronociception, since they release a myriad of inflammatory algogens which interact with neurons to…”
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Potentiation of morphine-induced mechanical antinociception by sigma 1 receptor inhibition: Role of peripheral sigma 1 receptors by Sanchez-Fernandez, Cristina, Nieto, Francisco Rafael, Gonzalez-Cano, Rafael, Artacho-Cordon, Antonia, Romero, Lucia, Montilla-Garcia, Angeles, Zamanillo, Daniel, Baeyens, Jose Manuel, Entrena, Jose Manuel, Cobos, Enrique Jose

“…We studied the modulation of morphine-induced mechanical antinociception and side effects by sigma 1 receptor inhibition. Both wild-type (WT) and sigma 1…”
Get full text