Search Results - "Montgomery, Magdalene K."

The liver as an endocrine organ - linking NAFLD and insulin resistance by Watt, Matthew J, Miotto, Paula M, De Nardo, William, Montgomery, Magdalene K

“…The liver is a dynamic organ that plays critical roles in many physiological processes, including the regulation of systemic glucose and lipid metabolism…”
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Mitochondrial dysfunction and insulin resistance: an update by Montgomery, Magdalene K, Turner, Nigel

“…Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR); however, a large variety of association and intervention studies…”
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The role of mitochondrial sirtuins in health and disease by Osborne, Brenna, Bentley, Nicholas L., Montgomery, Magdalene K., Turner, Nigel

“…Mitochondria play a critical role in energy production, cell signalling and cell survival. Defects in mitochondrial function contribute to the ageing process…”
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Phospholipid metabolism in the liver – Implications for phosphatidylserine in non-alcoholic fatty liver disease by Anari, Marziyeh, Montgomery, Magdalene K.

“…[Display omitted] Mammalian cells contain more than a thousand different glycerophospholipid species that are essential membrane components and signalling…”
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Mitochondrial Dysfunction and Diabetes: Is Mitochondrial Transfer a Friend or Foe? by Montgomery, Magdalene K

“…Obesity, insulin resistance and type 2 diabetes are accompanied by a variety of systemic and tissue-specific metabolic defects, including inflammation,…”
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Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer by Watt, Matthew J, Clark, Ashlee K, Selth, Luke A, Haynes, Vanessa R, Lister, Natalie, Rebello, Richard, Porter, Laura H, Niranjan, Birunthi, Whitby, Sarah T, Lo, Jennifer, Huang, Cheng, Schittenhelm, Ralf B, Anderson, Kimberley E, Furic, Luc, Wijayaratne, Poornima R, Matzaris, Maria, Montgomery, Magdalene K, Papargiris, Melissa, Norden, Sam, Febbraio, Maria, Risbridger, Gail P, Frydenberg, Mark, Nomura, Daniel K, Taylor, Renea A

“…Metabolism alterations are hallmarks of cancer, but the involvement of lipid metabolism in disease progression is unclear. We investigated the role of lipid…”
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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging by Gomes, Ana P., Price, Nathan L., Ling, Alvin J.Y., Moslehi, Javid J., Montgomery, Magdalene K., Rajman, Luis, White, James P., Teodoro, João S., Wrann, Christiane D., Hubbard, Basil P., Mercken, Evi M., Palmeira, Carlos M., de Cabo, Rafael, Rolo, Anabela P., Turner, Nigel, Bell, Eric L., Sinclair, David A.

“…Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities,…”
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A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism by Turner, Nigel, Lim, Xin Ying, Toop, Hamish D., Osborne, Brenna, Brandon, Amanda E., Taylor, Elysha N., Fiveash, Corrine E., Govindaraju, Hemna, Teo, Jonathan D., McEwen, Holly P., Couttas, Timothy A., Butler, Stephen M., Das, Abhirup, Kowalski, Greg M., Bruce, Clinton R., Hoehn, Kyle L., Fath, Thomas, Schmitz-Peiffer, Carsten, Cooney, Gregory J., Montgomery, Magdalene K., Morris, Jonathan C., Don, Anthony S.

“…Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family, are believed to regulate metabolic physiology. Genetic mouse models…”
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Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance by Keenan, Stacey N., Watt, Matthew J., Montgomery, Magdalene K.

“…Purpose of Review Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been disputed for decades. This review…”
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Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control by Keenan, Stacey N., De Nardo, William, Lou, Jieqiong, Schittenhelm, Ralf B., Montgomery, Magdalene K., Granneman, James G., Hinde, Elizabeth, Watt, Matthew J.

“…Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid…”
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Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity by Dávalos-Salas, Mercedes, Montgomery, Magdalene K., Reehorst, Camilla M., Nightingale, Rebecca, Ng, Irvin, Anderton, Holly, Al-Obaidi, Sheren, Lesmana, Analia, Scott, Cameron M., Ioannidis, Paul, Kalra, Hina, Keerthikumar, Shivakumar, Tögel, Lars, Rigopoulos, Angela, Gong, Sylvia J., Williams, David S., Yoganantharaja, Prusoth, Bell-Anderson, Kim, Mathivanan, Suresh, Gibert, Yann, Hiebert, Scott, Scott, Andrew M., Watt, Matthew J., Mariadason, John M.

“…Histone deacetylase 3 ( Hdac3 ) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulating lipid metabolism in the…”
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Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle[S] by Montgomery, Magdalene K., Osborne, Brenna, Brown, Simon H.J., Small, Lewin, Mitchell, Todd W., Cooney, Gregory J., Turner, Nigel

“…Dietary intake of long-chain fatty acids (LCFAs) plays a causative role in insulin resistance and risk of diabetes. Whereas LCFAs promote lipid accumulation…”
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Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress-Fibroblast Growth Factor 21 Axis in Skeletal Muscle by Montgomery, Magdalene K, Mokhtar, Ruzaidi, Bayliss, Jacqueline, Parkington, Helena C, Suturin, Victor M, Bruce, Clinton R, Watt, Matthew J

“…Lipid droplets (LDs) are critical for the regulation of lipid metabolism, and dysregulated lipid metabolism contributes to the pathogenesis of several…”
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Regulation of mitochondrial metabolism in murine skeletal muscle by the medium‐chain fatty acid receptor Gpr84 by Montgomery, Magdalene K., Osborne, Brenna, Brandon, Amanda E., O'Reilly, Liam, Fiveash, Corrine E., Brown, Simon H. J., Wilkins, Brendan P., Samsudeen, Azrah, Yu, Josephine, Devanapalli, Beena, Hertzog, Ashley, Tolun, Adviye A., Kavanagh, Tomas, Cooper, Antony A., Mitchell, Todd W., Biden, Trevor J., Smith, Nicola J., Cooney, Gregory J., Turner, Nigel

“…Fatty acid receptors have been recognized as important players in glycaemic control. This study is the first to describe a role for the medium‐chain fatty acid…”
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Mouse strain-dependent variation in metabolic associated fatty liver disease (MAFLD): a comprehensive resource tool for pre-clinical studies by Karimkhanloo, Hamzeh, Keenan, Stacey N., Bayliss, Jacqueline, De Nardo, William, Miotto, Paula M., Devereux, Camille J., Nie, Shuai, Williamson, Nicholas A., Ryan, Andrew, Watt, Matthew J., Montgomery, Magdalene K.

“…Non-alcoholic steatohepatitis (NASH), characterized as the joint presence of steatosis, hepatocellular ballooning and lobular inflammation, and liver fibrosis…”
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Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control by Montgomery, Magdalene K., Bayliss, Jacqueline, Nie, Shuai, De Nardo, William, Keenan, Stacey N., Miotto, Paula M., Karimkhanloo, Hamzeh, Huang, Cheng, Schittenhelm, Ralf B., Don, Anthony S., Ryan, Andrew, Williamson, Nicholas A., Ooi, Geraldine J., Brown, Wendy A., Burton, Paul R., Parker, Benjamin L., Watt, Matthew J.

“…Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, yet the pathophysiological mechanisms underpinning this bidirectional relationship…”
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Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant–mitochondrial response in mouse beta cells by Bensellam, Mohammed, Montgomery, Magdalene K., Luzuriaga, Jude, Chan, Jeng Yie, Laybutt, D. Ross

“…Aims/hypothesis Oxidative stress is implicated in beta cell glucotoxicity in type 2 diabetes. Inhibitor of differentiation (ID) proteins are transcriptional…”
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The long life of birds: the rat-pigeon comparison revisited by Montgomery, Magdalene K, Hulbert, A J, Buttemer, William A

“…The most studied comparison of aging and maximum lifespan potential (MLSP) among endotherms involves the 7-fold longevity difference between rats (MLSP 5y) and…”
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Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism by De Nardo, William, Miotto, Paula M., Bayliss, Jacqueline, Nie, Shuai, Keenan, Stacey N., Montgomery, Magdalene K., Watt, Matthew J.

“…Non-alcoholic fatty liver disease (NAFLD) is linked to impaired lipid metabolism and systemic insulin resistance, which is partly mediated by altered secretion…”
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Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration by Weston-Green, Katrina, Babic, Ilijana, de Santis, Michael, Pan, Bo, Montgomery, Magdalene K, Mitchell, Todd, Huang, Xu-Feng, Nealon, Jessica

“…Second generation antipsychotics (SGAs) induce glucometabolic side-effects, such as hyperglycemia and insulin resistance, which pose a therapeutic challenge…”
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