Search Results - "Montgomery, Diana L"
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Hsp70 Chaperone Ligands Control Domain Association via an Allosteric Mechanism Mediated by the Interdomain Linker
Published in Molecular cell (13-04-2007)“…Hsp70 chaperones assist in protein folding, disaggregation, and membrane translocation by binding to substrate proteins with an ATP-regulated affinity that…”
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A Phase 1 Randomized, Double‐Blind, Placebo‐Controlled Trial to Assess the Safety, Tolerability, and Pharmacokinetics of a Respiratory Syncytial Virus Neutralizing Monoclonal Antibody MK‐1654 in Healthy Adults
Published in Clinical pharmacology in drug development (01-05-2021)“…Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infection and related morbidity and mortality in infants. Passive…”
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Assessment of Bezlotoxumab Immunogenicity
Published in Clinical pharmacology in drug development (01-04-2020)“…Bezlotoxumab is a fully human monoclonal antibody that binds and neutralizes Clostridium difficile toxin B. This analysis investigated the potential of…”
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Dependence of endoplasmic reticulum-associated degradation on the peptide binding domain and concentration of BiP
Published in Molecular biology of the cell (01-08-2003)“…ER-associated degradation (ERAD) removes defective and mis-folded proteins from the eukaryotic secretory pathway, but mutations in the ER lumenal Hsp70,…”
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Structural insights into substrate binding by the molecular chaperone DnaK
Published in Nature structural biology (01-04-2000)“…How substrate affinity is modulated by nucleotide binding remains a fundamental, unanswered question in the study of 70 kDa heat shock protein (Hsp70)…”
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Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling
Published in Journal of molecular biology (26-02-1999)“…In Escherichia coli, DnaK is essential for the replication of bacteriophage lambda DNA; this in vivo activity provides the basis of a screen for mutations…”
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Comparison of Teacher, Peer, and Self-Ratings of Classroom and Social Behavior of Adolescents
Published in Behavioral disorders (01-05-1983)“…The present study assessed the concurrent validity of three methods of measuring classroom and social behavior — teacher ratings, peer roster ratings, and…”
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Thermodynamic and structural analysis of the folding/unfolding transitions of the Escherichia coli 70 kilodalton heat shock protein, DnaK
Published 01-01-1994“…This work presents a thermodynamic characterization of the folding/unfolding domains of the E. coli 70 kD heat shock protein, DnaK. Calorimetric scans of DnaK…”
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Dissertation -
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A mild method for the preparation of disulfide-linked hybrids of immunoglobulin light chains
Published in Molecular immunology (01-03-1987)“…A method is described for the hybridization of immunoglobulin light chains (Bence-Jones proteins) from different patients. The interchain half-cystine residues…”
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