Glucagon-like peptide 1 and Glucagon-like peptide 2 in relation to osteoporosis in non-diabetic postmenopausal women

Glucagon-like peptide 1 and Glucagon-like peptide 2 in relation to osteoporosis in non-diabetic postmenopausal women

Osteoporosis results from an imbalance in bone remodeling, which is known to follow a circadian rhythm determined by a functional relationship between intestine and bone tissue. Specific intestinal peptides have been identified as mediators. Glucagon-like peptide 1 and glucagon-like peptide 2, have...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports Vol. 9; no. 1; pp. 13651 - 8
Main Authors: Montes Castillo, María Cristina, Martínez Ramírez, María José, Soriano Arroyo, Rubén, Prieto Gomez, Isabel, Segarra Robles, Ana Belén, Garrido-Martínez, Macarena, Santiago-Fernández, Piedad, Delgado Rodríguez, Miguel
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 20-09-2019
Nature Publishing Group
Subjects:
692/163/2743/316/801
692/4020/198
82/75
Absorptiometry, Photon
Antagonist drugs
Bone Density
Bone mineral density
Bone remodeling
Case-Control Studies
Circadian rhythms
Diabetes
Diabetes mellitus
Dipeptidyl Peptidase 4 - blood
Dipeptidyl-peptidase IV
Dual energy X-ray absorptiometry
Eating
Female
Food intake
Glucagon
Glucagon-like peptide 1
Glucagon-Like Peptide 1 - blood
Glucagon-like peptide 2
Glucagon-Like Peptide 2 - blood
Group therapy
Humanities and Social Sciences
Humans
Intestine
Middle Aged
multidisciplinary
Osteoporosis
Osteoporosis, Postmenopausal - blood
Osteoporosis, Postmenopausal - diagnostic imaging
Peptidase
Peptides
Plasma levels
Post-menopause
Postprandial Period
Regression analysis
Science
Science (multidisciplinary)
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Osteoporosis results from an imbalance in bone remodeling, which is known to follow a circadian rhythm determined by a functional relationship between intestine and bone tissue. Specific intestinal peptides have been identified as mediators. Glucagon-like peptide 1 and glucagon-like peptide 2, have been associated with bone health. Our main objective was to determine whether postprandial plasma levels of glucagon-like peptide 1, glucagon-like peptide 2 and dipeptidyl-peptidase 4 activity, are associated with osteoporosis in non-diabetic postmenopausal women. We studied non-diabetic postmenopausal women with osteoporosis diagnosed by dual-energy X-ray absorptiometry (cases, n = 43) and age-matched (±1 yr) controls without osteoporosis or a history of osteoporotic fracture (n = 43). We measured postprandial plasma levels of glucagon-like peptide 1, glucagon-like peptide 2, and dipeptidyl-peptidase 4 activity, bone mineral density, and baseline levels of bone remodeling markers and analyzed the food intake using a food-frequency questionnaire. Postprandial glucagon-like peptide 1 values were lower (p < 0.001) in cases, μ (SEM) = 116.25 (2.68), than in controls, μ (SEM) = 126.79 (2.68). Glucagon-like peptide 1 was associated with reduced osteoporosis risk in the crude logistic regression analysis [OR (95% CI) = 0.724 (0.53–0.97), p = 0.031] and adjusted analysis [OR = 0.603 (0.38–0.94), p = 0.027]. We found no association of glucagon-like peptide 2, or dipeptidyl-peptidase 4 activity with osteoporosis. Postprandial glucagon-like peptide 1 levels are related to osteoporosis and osteoporosis risk in non-diabetic postmenopausal women. Further studies are required to verify these findings.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-50117-z