Third-generation progestogen type influences hemostatic changes caused by oral contraceptives in Brazilian women

We compared the effects of two third-generation progestogens, desogestrel (DSG) and gestodene (GSD), on coagulation and fibrinolysis in Brazilian users of oral contraceptives (OCs). Forty-six women were evaluated before treatment and after six cycles of treatment. The coagulation, anticoagulant, and...

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Bibliographic Details
Published in:	Contraception (Stoneham) Vol. 64; no. 6; pp. 353 - 356
Main Authors:	Ferreira, A.C.P, Montes, M.B.A, Franceschini, S.A, Toloi, M.R.T
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-12-2001 Elsevier Science
Subjects:	Adult Biological and medical sciences Blood Coagulation - drug effects Brazil - epidemiology Coagulation Protein Disorders - blood Coagulation Protein Disorders - chemically induced Coagulation Protein Disorders - epidemiology Coagulation Protein Disorders - prevention & control Contraceptives, Oral - adverse effects Contraceptives, Oral, Synthetic - administration & dosage Contraceptives, Oral, Synthetic - pharmacology Desogestrel Desogestrel - administration & dosage Desogestrel - pharmacology Drug toxicity and drugs side effects treatment Ethinyl estradiol Ethnic Groups Female Fibrinolysis - drug effects Gestodene Hemostasis Hemostasis - drug effects Humans Medical sciences Norpregnenes - administration & dosage Norpregnenes - pharmacology Oral contraceptives Pharmacology. Drug treatments Progesterone Congeners - administration & dosage Progesterone Congeners - pharmacology Thrombosis Toxicity: blood South America Brazil America Ethinyl estradiol Desogestrel Gestodene Oral contraceptives Hemostasis Thrombosis Ethinylestradiol Human Blood coagulation Toxicity Estrogen Oral administration Cardiovascular disease Fibrinolysis Venous disease Progestagen Vascular disease Female Contraceptive Sex steroid hormone Vein Comparative study
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Summary:	We compared the effects of two third-generation progestogens, desogestrel (DSG) and gestodene (GSD), on coagulation and fibrinolysis in Brazilian users of oral contraceptives (OCs). Forty-six women were evaluated before treatment and after six cycles of treatment. The coagulation, anticoagulant, and fibrinolytic systems were investigated. During the use of the DSG-containing OC, the activity of factors VII, VIII, IX, X, and XII increased significantly whereas the GSD-containing OC caused no changes in coagulation parameters. Concerning the anticoagulant pathways, the DSG-containing OC increased protein C levels and decreased total protein S levels, and the GSD-containing OC only decreased total protein S. Both OCs increased plasminogen activity, although the DSG-containing OC increased fibrin degradation products levels and decreased the tissue plasminogen activator antigen. In conclusion, we have found that in Brazilian women the effects of DSG and GSD on hemostatic parameters are different and, therefore, third-generation progestogens may not contribute equally to the thrombotic risk.
ISSN:	0010-7824 1879-0518
DOI:	10.1016/S0010-7824(01)00274-8