Search Results - "Monteleone, Emanuele"

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway by Lee, Yu-Ru, Chen, Ming, Lee, Jonathan D, Zhang, Jinfang, Lin, Shu-Yu, Fu, Tian-Min, Chen, Hao, Ishikawa, Tomoki, Chiang, Shang-Yin, Katon, Jesse, Zhang, Yang, Shulga, Yulia V, Bester, Assaf C, Fung, Jacqueline, Monteleone, Emanuele, Wan, Lixin, Shen, Chen, Hsu, Chih-Hung, Papa, Antonella, Clohessy, John G, Teruya-Feldstein, Julie, Jain, Suresh, Wu, Hao, Matesic, Lydia, Chen, Ruey-Hwa, Wei, Wenyi, Pandolfi, Pier Paolo

“…Activation of tumor suppressors for the treatment of human cancer has been a long sought, yet elusive, strategy. PTEN is a critical tumor suppressive…”
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Nucleosomes effectively shield DNA from radiation damage in living cells by Brambilla, Francesca, Garcia-Manteiga, Jose Manuel, Monteleone, Emanuele, Hoelzen, Lena, Zocchi, Angelica, Agresti, Alessandra, Bianchi, Marco E

“…Abstract Eukaryotic DNA is organized in nucleosomes, which package DNA and regulate its accessibility to transcription, replication, recombination and repair…”
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Chromatin organization drives the search mechanism of nuclear factors by Mazzocca, Matteo, Loffreda, Alessia, Colombo, Emanuele, Fillot, Tom, Gnani, Daniela, Falletta, Paola, Monteleone, Emanuele, Capozi, Serena, Bertrand, Edouard, Legube, Gaelle, Lavagnino, Zeno, Tacchetti, Carlo, Mazza, Davide

“…Nuclear factors rapidly scan the genome for their targets, but the role of nuclear organization in such search is uncharted. Here we analyzed how multiple…”
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Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy by Mugoni, Vera, Panella, Riccardo, Cheloni, Giulia, Chen, Ming, Pozdnyakova, Olga, Stroopinsky, Dina, Guarnerio, Jlenia, Monteleone, Emanuele, Lee, Jonathan David, Mendez, Lourdes, Menon, Archita Venugopal, Aster, Jon Christopher, Lane, Andrew A., Stone, Richard Maury, Galinsky, Ilene, Zamora, José Cervera, Lo-Coco, Francesco, Bhasin, Manoj Kumar, Avigan, David, Longo, Letizia, Clohessy, John Gerard, Pandolfi, Pier Paolo

“…Although targeted therapies have proven effective and even curative in human leukaemia, resistance often ensues. IDH enzymes are mutated in ~20% of human AML,…”
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CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-κB and STAT3 Transcription Factors on the Proximal Promoter by Kunkl, Martina, Mastrogiovanni, Marta, Porciello, Nicla, Caristi, Silvana, Monteleone, Emanuele, Arcieri, Stefano, Tuosto, Loretta

“…CD28 is an important co-stimulatory receptor for T lymphocytes that, in humans, delivers TCR-independent signal leading to the up-regulation of…”
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Exploring circular MET RNA as a potential biomarker in tumors exhibiting high MET activity by Bersani, Francesca, Picca, Francesca, Morena, Deborah, Righi, Luisella, Napoli, Francesca, Russo, Mariangela, Oddo, Daniele, Rospo, Giuseppe, Negrino, Carola, Castella, Barbara, Volante, Marco, Listì, Angela, Zambelli, Vanessa, Benso, Federica, Tabbò, Fabrizio, Bironzo, Paolo, Monteleone, Emanuele, Poli, Valeria, Pietrantonio, Filippo, Di Nicolantonio, Federica, Bardelli, Alberto, Ponzetto, Carola, Novello, Silvia, Scagliotti, Giorgio V, Taulli, Riccardo

“…MET-driven acquired resistance is emerging with unanticipated frequency in patients relapsing upon molecular therapy treatments. However, the determination of…”
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Small transcriptional differences among cell clones lead to distinct NF-κB dynamics by Kizilirmak, Cise, Monteleone, Emanuele, García-Manteiga, José Manuel, Brambilla, Francesca, Agresti, Alessandra, Bianchi, Marco E., Zambrano, Samuel

“…Transcription factor dynamics is fundamental to determine the activation of accurate transcriptional programs and yet is heterogeneous at a single-cell level,…”
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Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms by Circosta, Paola, Elia, Angela Rita, Landra, Indira, Machiorlatti, Rodolfo, Todaro, Maria, Aliberti, Sabrina, Brusa, Davide, Deaglio, Silvia, Chiaretti, Sabina, Bruna, Riccardo, Gottardi, Daniela, Massaia, Massimo, Giacomo, Filomena Di, Guarini, Anna Rita, Foà, Robin, Kyriakides, Peter W., Bareja, Rohan, Elemento, Olivier, Chichili, Gurunadh R., Monteleone, Emanuele, Moore, Paul A., Johnson, Syd, Bonvini, Ezio, Cignetti, Alessandro, Inghirami, Giorgio

“…Many patients with B-cell malignancies can be successfully treated, although tumor eradication is rarely achieved. T-cell-directed killing of tumor cells using…”
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Where Sin3a Meets STAT3: Balancing STAT3-Mediated Transcriptional Activation and Repression by Monteleone, Emanuele, Poli, Valeria

“…STAT3 can mediate epigenetic silencing of tumor suppressor genes (TSG). However, little is known about the molecular mechanisms involved, except that this…”
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mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide by Matsumoto, Akinobu, Pasut, Alessandra, Matsumoto, Masaki, Yamashita, Riu, Fung, Jacqueline, Monteleone, Emanuele, Saghatelian, Alan, Nakayama, Keiichi I., Clohessy, John G., Pandolfi, Pier Paolo

“…The polypeptide SPAR is encoded by a long non-coding RNA, localizes to the late endosome and lysosome, and regulates muscle regeneration by inhibiting mTORC1…”
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STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts by Avalle, Lidia, Raggi, Laura, Monteleone, Emanuele, Savino, Aurora, Viavattene, Daniele, Statello, Luisa, Camperi, Andrea, Stabile, Simona Aversano, Salemme, Vincenzo, De Marzo, Niccolò, Marino, Francesca, Guglielmi, Chiara, Lobascio, Andrea, Zanini, Cristina, Forni, Marco, Incarnato, Danny, Defilippi, Paola, Oliviero, Salvatore, Poli, Valeria

“…In the tumor microenvironment, Cancer Associated Fibroblasts (CAFs) become activated by cancer cells and increase their secretory activity to produce soluble…”
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Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita by Nachmani, Daphna, Bothmer, Anne H., Grisendi, Silvia, Mele, Aldo, Bothmer, Dietmar, Lee, Jonathan D., Monteleone, Emanuele, Cheng, Ke, Zhang, Yang, Bester, Assaf C., Guzzetti, Alison, Mitchell, Caitlin A., Mendez, Lourdes M., Pozdnyakova, Olga, Sportoletti, Paolo, Martelli, Maria-Paola, Vulliamy, Tom J., Safra, Modi, Schwartz, Schraga, Luzzatto, Lucio, Bluteau, Olivier, Soulier, Jean, Darnell, Robert B., Falini, Brunangelo, Dokal, Inderjeet, Ito, Keisuke, Clohessy, John G., Pandolfi, Pier Paolo

“…RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are…”
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STAT3-dependent long non-coding RNA Lncenc1 contributes to mouse ES cells pluripotency via stabilizing Klf4 mRNA by Monteleone, Emanuele, Corrieri, Paola, Provero, Paolo, Viavattene, Daniele, Pulvirenti, Lorenzo, Raggi, Laura, Carbognin, Elena, Bianchi, Marco E, Martello, Graziano, Oliviero, Salvatore, Pandolfi, Pier Paolo, Poli, Valeria

“…Embryonic stem cells (ESCs) preserve the unique ability to differentiate into any somatic cell lineage while maintaining their self-renewal potential, relying…”
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Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination by Fumagalli, Valeria, Ravà, Micol, Marotta, Davide, Di Lucia, Pietro, Bono, Elisa B., Giustini, Leonardo, De Leo, Federica, Casalgrandi, Maura, Monteleone, Emanuele, Mouro, Violette, Malpighi, Chiara, Perucchini, Chiara, Grillo, Marta, De Palma, Sara, Donnici, Lorena, Marchese, Silvia, Conti, Matteo, Muramatsu, Hiromi, Perlman, Stanley, Pardi, Norbert, Kuka, Mirela, De Francesco, Raffaele, Bianchi, Marco E., Guidotti, Luca G., Iannacone, Matteo

“…Vaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality, yet emerging variants challenge their…”
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SP1 and STAT3 Functionally Synergize to Induce the RhoU Small GTPase and a Subclass of Non-canonical WNT Responsive Genes Correlating with Poor Prognosis in Breast Cancer by Monteleone, Emanuele, Orecchia, Valeria, Corrieri, Paola, Schiavone, Davide, Avalle, Lidia, Moiso, Enrico, Savino, Aurora, Molineris, Ivan, Provero, Paolo, Poli, Valeria

“…Breast cancer is a heterogeneous disease whose clinical management is very challenging. Although specific molecular features characterize breast cancer…”
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An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance by Bester, Assaf C., Lee, Jonathan D., Chavez, Alejandro, Lee, Yu-Ru, Nachmani, Daphna, Vora, Suhani, Victor, Joshua, Sauvageau, Martin, Monteleone, Emanuele, Rinn, John L., Provero, Paolo, Church, George M., Clohessy, John G., Pandolfi, Pier Paolo

“…Resistance to chemotherapy plays a significant role in cancer mortality. To identify genetic units affecting sensitivity to cytarabine, the mainstay of…”
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STAT3 Activities and Energy Metabolism: Dangerous Liaisons by Camporeale, Annalisa, Demaria, Marco, Monteleone, Emmanuelle, Giorgi, Carlotta, Wieckowski, Mariusz R, Pinton, Paolo, Poli, Valeria

“…STAT3 mediates cytokine and growth factor receptor signalling, becoming transcriptionally active upon tyrosine 705 phosphorylation (Y-P). Constitutively Y-P…”
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