Search Results - "Montejo de Garcini, E"

The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers by Cuadros, R, Montejo de Garcini, E, Wandosell, F, Faircloth, G, Fernández-Sousa, J.M, Avila, J

“…Spisulosine is a novel antiproliferative (antitumoral) compound of marine origin. In this work the molecular target for this toxic agent has been analyzed. In…”
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In Vitro Assembly of Tau Protein:  Mapping the Regions Involved in Filament Formation by Pérez, M, Arrasate, M, Montejo de Garcini, E, Muñoz, V, Avila, J

“…Unraveling the mechanism of self-assembly of the protein tau into paired helical filaments (PHFs) is a crucial step toward the understanding of Alzheimer's and…”
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Microtubule‐associated protein MAP2 preferentially binds to a dA/dT sequence present in mouse satellite DNA by Avila, J., Montejo de Garcini, E., Wandosell, F., Villasante, A., Sogo, J.M., Villanueva, N.

“…Microtubule‐associated protein MAP2 binds to the Sau96.1 restriction monomer fragment of mouse satellite DNA. This fragment is also present in a lower…”
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The role of tau phosphorylation in transfected COS-1 cells by Medina, M, Montejo de Garcini, E, Avila, J

“…Tau cDNAs from each of the six human isoforms were transfected into COS-1 cells and, in every case, more than one peptide was observed. The diversity of…”
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Localization of the tubulin binding site for tau protein by SERRANO, Luis, MONTEJO DE GARCINI, Esteban, HERNÁNDEZ, María Angeles, AVILA, Jesús

“…Limited proteolysis of tubulin with subtilisin resulted in the removal of the carboxyl‐terminal moiety of tubulin subunits. The remaining peptides from both α…”
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Measurement of Distinct Immunochemical Presentations of Tau Protein in Alzheimer Disease by Harrington, Charles R., Mukaetova-Ladinska, Elizabeta B., Hills, Richard, Edwards, Patricia C., De Garcini, Esteban Montejo, Novak, Michael, Wischik, Claude M.

“…The tau protein is a microtubule-associated protein that is normally located in nerve axons. In Alzheimer disease, it is a constituent of paired helical…”
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Altered levels of microtubule proteins in brains of Alzheimer's disease patients by NIETO, A, MONTEJO DE GARCINI, E, AVILA, J

“…The amount of microtubule protein present in the total soluble protein from brains of Alzheimer's disease patients and from brains of non-Alzheimer age-matched…”
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Differentiation of neuroblastoma cells correlates with an altered splicing pattern of tau RNA by de Garcini, E.Montejo, Corrochano, Luis, Wischik, C.M., Nido, J.Diaz, Correas, I., Avila, J.

“…Morphological differentiation of N2A nouroblastoma cells is associated with an altered splicing of the gene of the microtubule-associated protein, tau. Two…”
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Overexpression of tau protein in COS-1 cells results in the stabilization of centrosome-independent microtubules and extension of cytoplasmic processes by MONTEJO DE GARCINI, E, DE LA LUNA, S, DOMINGUEZ, J. E, AVILA, J

“…COS-1 cells were transfected with cDNAs coding for different human tau isoforms. Expressed tau isoforms bind to cellular microtubules in vivo, preferentially…”
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Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction by Pérez, M, Valpuesta, J M, Medina, M, Montejo de Garcini, E, Avila, J

“…Paired helical filaments isolated from the brains of patients with Alzheimer's disease are composed of a major protein component, the microtubule-associated…”
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Characterization of tau protein present in microtubules and paired helical filaments of Alzheimer's disease patient's brain by Nieto, A, Montejo de Garcini, E, Correas, I, Avila, J

“…Two proteins immunologically related to porcine tau protein are found in the brain of Alzheimer's disease patients. One is bound to microtubules and, after…”
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Collagenous structures present in brain contain epitopes shared by collagen and microtubule-associated protein tau by Montejo de Garcini, E, Carrascosa, J L, Nieto, A, Avila, J

“…A novel type of collagenous fibers has been isolated from human brain and characterized by electron microscopy and optical diffraction. It was found that the…”
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The interaction between a Na+-channel toxin and brain microtubule proteins in vitro by Hargreaves, A J, Montejo de Garcini, E, Avila, J

“…The aim of this work was to characterize the interaction of the Na+-channel toxin, purified from venom of the scorpion Leiurus quinquestriatus, with…”
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Glycogen synthase kinase 3 phosphorylates recombinant human tau protein at serine-262 in the presence of heparin (or tubulin) by Moreno, Francisco J., Medina, Miguel, Pérez, Mar, Montejo de Garcini, Esteban, Avila, Jesús

“…Tau protein, the major component of the aberrant structures termed paired helical filaments (PHFs) present in the brain of Alzheimer's disease patients, is…”
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Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy by Perez, M, Valpuesta, JM, de Garcini, EM, Quintana, C, Arrasate, M, Lopez Carrascosa, JL, Rabano, A, Garcia de Yebenes, J, Avila, J

“…Tau-containing filaments purified from the brain of progressive supranuclear palsy (PSP) patients were isolated and characterized. These filaments co-purify…”
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Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease by Montejo de Garcini, E, Serrano, L, Avila, J

“…Microtubule associated protein tau factor self-assembles into filamentous structures resembling the paired helical filaments found in Alzheimer disease. Tau…”
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Tau factor polymers are similar to paired helical filaments of Alzheimer's disease by de Garcini, Esteban Montejo, Carrascosa, José L., Correas, Isabel, Nieto, Amelia, Avila, Jesús

“…Tau factor, upon urea treatment, is able to polymerize in vitro. These polymers are composed of tau factor as shown by immunogold staining. The structure of…”
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A modified form of microtubule-associated tau protein is the main component of paired helical filaments by Nieto, A, Correas, I, Montejo de Garcini, E, Avila, J

“…Paired helical filaments, which are present in the brain of Alzheimer's disease patients have been isolated and characterized. Treatment of the filaments with…”
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Protein kinases involved in the phosphorylation of human tau protein in transfected COS-1 cells by Medina, Miguel, García-Rocha, Mar, Padilla, Rodolfo, Pérez, Mar, de Garcini, Esteban Montejo, Avila, Jesús

“…Human tau phosphorylation has been studied in transfected COS-1 cells. Treatment with okadaic acid alters the electrophoretic mobility of human tau protein…”
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Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients by Ulloa, L, Montejo de Garcini, E, Gómez-Ramos, P, Morán, M A, Avila, J

“…Alzheimer's disease results in the appearance of cytoskeletal disorders yielding pathological structures such a neurofibrillary tangles or dystrophic neurites…”
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