Outcome of infections caused by multiple drug–resistant bacteria in liver transplant recipients

To evaluate the impact of infections caused by multiple-drug-resistant (MDR) bacteria on the clinical outcome of liver transplant recipients. Retrospective study including all episodes of bacterial infection diagnosed in patients undergoing liver transplantation from January 19, 1999, to June 30, 20...

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Bibliographic Details
Published in:	Transplantation proceedings Vol. 36; no. 4; pp. 958 - 960
Main Authors:	Gouvêa, E.F, Branco, R.C, Monteiro, R.C.M, Halpern, M, Ribeiro-Filho, J, Silveira, V.G, Tavares, G.C, Rodrigues, M.S, Coelho, H.S.M, Basto, S.T, Santoro-Lopes, G
Format:	Journal Article Conference Proceeding
Language:	English
Published:	New York, NY Elsevier Inc 01-05-2004 Elsevier Science
Subjects:	Anti-Bacterial Agents Bacteria - classification Bacteria - drug effects Bacterial Infections - drug therapy Bacterial Infections - epidemiology Biological and medical sciences Brazil Drug Resistance, Bacterial Drug Resistance, Multiple Drug Therapy, Combination - therapeutic use Humans Liver Transplantation - physiology Liver, biliary tract, pancreas, portal circulation, spleen Medical sciences Microbial Sensitivity Tests Postoperative Complications - microbiology Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Brazil Human Nosocomial infection Prognosis Digestive system Liver Transplantation Homotransplantation Infection Treatment Surgery Multiple resistance Bacteriosis Bacteria Evolution Graft
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Summary:	To evaluate the impact of infections caused by multiple-drug-resistant (MDR) bacteria on the clinical outcome of liver transplant recipients. Retrospective study including all episodes of bacterial infection diagnosed in patients undergoing liver transplantation from January 19, 1999, to June 30, 2002. The diagnosis of bacterial infection required microbiological documentation. Mortality associated with episodes of infection by MDR bacteria was compared to that observed after antibiotic-susceptible bacterial infections. Among 99 patients undergoing liver transplantation during the study period, there were 57 episodes of bacterial infections. Gram-negative bacilli were the predominant etiologic agents (76%) and Pseudomonas aeruginosa was the most frequent bacterial species found in these cases (23 isolates, 28%). Thirty-six episodes of infection (63%) were caused by MDR bacteria. Mean time after transplantation to the diagnosis of infection was 17 days. Mortality associated with episodes of MDR bacterial infections (nine deaths, 25%) was not significantly different from that observed during episodes of antibiotic-susceptible bacteria (five deaths, 24%; P = .92). These data suggest that resistance to multiple antimicrobial agents does not have an impact on the mortality associated to bacterial infections in liver transplant recipients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2004.03.123